Beitrag zur Morphologie der Niere beim akuten Nierenversagen

Böhle, A.; Herfarth, Ch.; Krecke, H. J.

doi:10.1007/bf01481233

Cited by 45 publications

(4 citation statements)

References 68 publications

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“…The greater weight of kidneys from animals in renal failure is insufficient, in terms of nephrographic density, to offset the low concentrations of diatrizoate. This increase in renal weight, approximately 30% , is comparable to that observed in acute renal failure in man [3], Mean values of serum urea and creatinine in animals in renal failure were nearly ten times those in control animals. In acute renal failure we found a negative correlation between these values and renal con centrations of diatrizoate, suggesting that the severity of the disease which we induced may explain low concentrations of contrast medium in the kidney.…”

Section: Discussionsupporting

confidence: 59%

Diatrizoate Levels in the Kidney and Lymph Nodes in Acute Renal Failure in the Rat

McLachlan¹,

Davies²,

Leach³

1974

Nephron

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Acute renal failure was induced in rats by intramuscular injection of glycerol. Concentrations of intravenous 125I-labelled sodium diatrizoate were measured in plasma, renal cortex and medulla, whole kidney and in lymph nodes draining the kidney. Whole kidney concentrations of diatrizoate, which changed little with time, were initially less than 20% of those in control animals. For 30 min after injection, while plasma levels were highest, renal concentrations in acute renal failure were highest in outer cortex. These observations provide further evidence that, though glomerular filtration continues in acute renal failure, it is much reduced. Diatrizoate was observed in renal lymph nodes from control animals and its existence there does not indicate tubular leakage. Smaller amounts were found in lymph nodes in acute renal failure, suggesting insignificant drainage of diatrizoate to renal lymphatics.

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Section: Discussionsupporting

confidence: 59%

Diatrizoate Levels in the Kidney and Lymph Nodes in Acute Renal Failure in the Rat

McLachlan¹,

Davies²,

Leach³

1974

Nephron

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“…6). In acute anuria the weight of the kidney is known to increase by at least 30% (37) because of swelling of the proximal tubules and interstitial edema (14,(37)(38)(39). In the present study, the estimated renal volumes of the anuric patients were significantly increased and averaged 302 ml.…”

mentioning

confidence: 99%

Renal Distribution Volumes of Indocyanine Green, [51Cr]EDTA, and 24Na in Man during Acute Renal Failure after Shock. IMPLICATIONS FOR THE PATHOGENESIS OF ANURIA

Reubi¹,

Vorburger²,

Tuckman³

1973

J. Clin. Invest.

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A Bs T R A C T The mechanism responsible for the anuria in acute renal failure after shock is still controversial.Suppressed glomerular filtration and/or tubular backdiffusion of the filtrate are major possible causes. In the present investigation, seven patients with acute anuria, three of these seven again in the polyuric phase, six patients with moderate renal impairment, four patients with chronic renal failure, and eight subjects with normal renal function were studied by a multiple indicatordilution method in which the total renal blood flow and renal distribution volumes of indocyanine green, ['Cr]-EDTA, and 'Na were determined. In normal subjects the average values for one kidney were 582 ml/min, 42 ml, 92 ml, and 139 ml, respectively. The measurements in the patients with moderate renal impairment were similar to those in the normal subjects, but were decreased in chronic renal failure. In acute anuria, the average values were 269 ml/min, 40 ml, 101 ml, and 114 ml and the kidney volume, estimated radiographically, was increased by 40%. When expressed as milliliters per milliliters kidney, the average distribution volume of 'Na was decreased from 0.64 to 0.38. This decrease is consistent with the hypothesis that suppressed filtration is largely responsible for the anuria and that back-diffusion is, at most, a contributory factor. The apparent contradiction between the relatively well-preserved total blood flow and the suppressed filtration may be due to a combination of afferent vasoconstriction and efferent vasodilatation. This view is supported by the observation that low filtration fractions were found in clearance measurements performed during the polyuric phase.

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“…The 30% increase in renal size in ARF in rats [17], which resembles that seen in man [2], cannot account for the large differences in concentration of diatrizoate between the ARF and control groups even at the highest dose where the difference is least. We find renal iodine content in ARF to be directly proportional to the injected dose of contrast medium.…”

Section: Discussionmentioning

confidence: 91%

Effect of Dose on Renal Diatrizoate Concentrations in Experimental Acute Renal Failure

Robinson¹,

Gaunt²,

McLachlan³

1976

Nephron

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In rats with glycerol-induced acute renal failure (ARF) and controls, renal concentrations of ¹²⁵I-labelled sodium diatrizoate were measured 5 min after intravenous doses ranging from 14 to 1,800 mg/kg body weight. Renal concentrations of diatrizoate, at all doses, were much higher in controls than in ARF. A linear relationship existed between dose and renal concentration in ARF. In controls, at doses above 225 mg/kg body weight, the fraction of the dose present in the kidneys diminished and renal iodine content approached that observed in ARF. Differences in diatrizoate concentration which existed between cortical and medullary zones in healthy kidneys at low doses were progressively eliminated as dosage increased, consistent with the osmotic diuretic effect of diatrizoate. In ARF, the pattern of intrarenal distribution at all doses was similar to that seen in controls at high doses, though concentrations in outer cortex were consistently slightly higher than those in inner cortex. These observations suggest continuing, though reduced, filtration of diatrizoate in ARF by glomeruli already subjected to a large solute load.

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Beitrag zur Morphologie der Niere beim akuten Nierenversagen

Cited by 45 publications

References 68 publications

Diatrizoate Levels in the Kidney and Lymph Nodes in Acute Renal Failure in the Rat

Diatrizoate Levels in the Kidney and Lymph Nodes in Acute Renal Failure in the Rat

Renal Distribution Volumes of Indocyanine Green, [51Cr]EDTA, and 24Na in Man during Acute Renal Failure after Shock. IMPLICATIONS FOR THE PATHOGENESIS OF ANURIA

Effect of Dose on Renal Diatrizoate Concentrations in Experimental Acute Renal Failure

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