Beitrag zur Funktionsprüfung des Reticuloendothelialen Apparates

Adler, Hugo; Reimann, F.

doi:10.1007/bf02608745

Cited by 60 publications

(5 citation statements)

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“…Notably, CR has been used for applications beyond detection of amyloidosis. Two years after Bennhold’s experiments (1925), Alder and Reimann [142] introduced the CR test as a reticuloendothelial system function test.…”

Section: The Use Of Cr In the Study Of Amyloidosismentioning

confidence: 99%

Congo Red and amyloids: history and relationship

et al. 2019

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Staining with Congo Red (CR) is a qualitative method used for the identification of amyloids in vitro and in tissue sections. However, the drawbacks and artefacts obtained when using this dye can be found both in vitro and in vivo. Analysis of scientific data from previous studies shows that CR staining alone is not sufficient for confirmation of the amyloid nature of protein aggregates in vitro or for diagnosis of amyloidosis in tissue sections. In the present paper, we describe the characteristics and limitations of other methods used for amyloid studies. Our historical review on the use of CR staining for amyloid studies may provide insight into the pitfalls and caveats related to this technique for researchers considering using this dye.

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Section: The Use Of Cr In the Study Of Amyloidosismentioning

confidence: 99%

Congo Red and amyloids: history and relationship

et al. 2019

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“…The In previous publications (Wetzler-Ligeti and Wiesner, 1937, 1938a, 1938b we have described the effects of various pituitary extracts upon the reticulo-endothelial system (RES) of the rabbit. Congo-red solution was injected intravenously and the rate at which the dye disappeared from the circulation was determined; this rate has been taken, in accordance with the view of previous authors (Adler and Reimann, 1925;Moncorps and Gunther, 1933 ;Dieryck, 1929;Stern and Willheim, 1935), as an index of the functional activity of the RES. It was found that certain anterior lobe extracts raised the Congo-red index by a considerable amount.…”

Section: Some Further Pointsmentioning

confidence: 84%

“…Determination of Congo-red Index Stern and Willheim's modification (1935) of the Congored method (Adler and Reimann, 1925) was again used. Virgin rabbits obtained from a commercial breeder were employed in these experiments.…”

Section: Some Further Pointsmentioning

confidence: 99%

The "Restropic" Activity of Blood

Wetzler-Ligeti¹,

Wiesner²

1938

BMJ

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“…Since Adler and Reimann (1925) adopted the Congo red test as a reticuloendothelial system (RES) function test, this method has been used extensively, experimentally and clinically, for the measurement of RES phagocytic activity (Yamagata et al 1954(Yamagata et al , 1955. As the Congo red test is a very easy procedure which is applicable to patients without any discomfort, there have been many studies on RES function using this method.…”

mentioning

confidence: 99%

“…However, to date there has been no definitive histological evidence to show that Congo red is phagocytized by the cells of the RES. Adler and Reimann (1925) first described that Congo red was phagocytized by RES; "Auch im einem Versuche am Menschen, dem wir anti exitum durch mehrere Tage gesamten 80cc 1%iger Kongorotlosung injizierten hatten, konnten wir in Leber and Milzallerdings nur sehr sparlich Farbstoff-granula nachweisen." Takeda (1930) reported that when as much as 32 nil/kg of 0.4% Congo red solution was injected, the dye was found in RES cells of liver, spleen, lymph nodes, lung and large intestine.…”

mentioning

confidence: 99%