Behcet's syndrome in 32 patients in Yorkshire.

Abstract

SUMMARY Thirty-two patients with Behcet's syndrome were surveyed clinically, radiologically, and immunologically. HLA antigens were determined in a proportion. The patients were culled from a defined geographical area (Yorkshire) with a population of 5 million. 21 patients satisfied Mason and Barnes's (1969) criteria for major disease. 100 % had mouth ulceration, 91 % genital ulceration, 66 % skin complaints, and 63 % arthritis (of the nonerosive type previously documented). 3 patients had gastrointestinal involvement, one of whom had proven Crohn's disease. One patient had psoriasis. One patient had a popliteal artery aneurysm resected and one has since had surgery after the development of a tracheo-oesophageal fistula. No sacroilititis was found.

Behcet's Disease in Saudi Arabia

“…11 This figure contrasts with the 26% seen in normal persons in this population. However, information on the pathergy test in this study was too inadequate to look for a correlation between it and the presence of HLA-B5(51) as others have done.…”

“…7,10 Like the others, our study confirms that Behcet's disease is not an uncommon disease in this region, 9 and the clinical manifestations also appear to be similar. 7,[9][10][11][12] However, interesting differences are also present. Neurologic manifestations were greater in severity and frequency in our study than in the others.…”

“…Neurologic manifestations were greater in severity and frequency in our study than in the others. 3,11,[13][14][15] On the other hand, there appear to have been more psychiatric manifestations in Kuwait 14 than either Riyadh or Iraq. 15 These differences may reflect an interest in the respective specialties in the different institutions.…”

The correlation of MHC haplotype and development of Behçet's disease-like symptoms induced by herpes simplex virus in several inbred mouse strains

“…The incidence of Behçet's disease in Middle Eastern countries is 1:10 000 [10], and 1:7500 in Japan [11]. In western countries such as the United States and the United Kingdom, the prevalence is estimated to be 5 per 100 000 population and 6.4 per million population, respectively, [12,13]. From these data, the genetic background to the incidence of Behçet's disease was raised.…”

Seronegative polyarthritis. a unified concept

“…We have looked at 32 patients with Behcet's Syndrome in Yorkshire (60). There were 12 males and 20 females.…”