Behçet’s disease leaves the silk road

Abstract

Behçet's disease is rarely recognized among Caucasians, while it is endemic in countries of the Eastern and Central Asia, especially in Turkey. The aim of the manuscript is to present the clinical picture, diagnosis criteria and therapeutic approaches of this rare disease which, because of intensive migration, can occur not only in particular regions of the world.

Bibliometric analysis on global Behçet disease publications during 1980–2014: is there a Silk Road in the literature?

“…Woźniacka et al . reported that although BD used to be a rare condition in European countries, the growing number of cases makes it required to alert physicians about the possibility of the occurrence of the disease among Caucasians living in areas other than Asia . We found that European countries had high productivity (Fig.…”

“…The diseases is endemic in Middle East, Mediterranean and Far Eastern countries with a prevalence of 13.5–500 per 100 000 population . Its incidence of BD is only 1 in 100 000 in the USA and 0.3 in 100 000 population in the UK . The highest prevalence of the disease has been reported in the geographical areas historically involved in the ancient Silk Road routes.…”

“…2 Its incidence of BD is only 1 in 100 000 in the USA and 0.3 in 100 000 population in the UK. 3 The highest prevalence of the disease has been reported in the geographical areas historically involved in the ancient Silk Road routes. BD is strongly associated with HLA-B51 which is a major histocompatibility complex antigen and the global distribution of HLA-B51 shows a striking similarity to the ancient Silk Road areas.…”

Analysis of altmetrics and additional metrics of the 50 most-cited Behçet articles of all time: A Web of Science-based study

“…Gastrointestinal, central nervous system, or vascular involvements may also be encountered and the most important risk factor is HLA-B51 positivity [11]. Although Behçet's disease is a rare condition in European countries, warnings have been issued about the possibility of an increase in the number of cases [12].…”

Serum ghrelin levels in patients with Behcet’s disease

“…Behcet’s disease (BD) is a multisystemic, chronic, inflammatory disease characterized with recurrent oral and genital ulcerations and uveitis attacks [1, 2]. While the disease etiopathogenesis is not fully known, emphasis is given to genetic factors, microbial agents, and endothelial cell dysfunction [1, 3, 4].…”