Most publications were reported from developed countries although undeveloped or developing countries had higher prevalence of BD. Physicians in undeveloped and developing countries should be supported and encouraged to perform novel studies on BD.

This study investigates the accuracy of an online Precise Point Positioning (PPP) service operated by the Geodetic Survey Division of Natural Resources Canada (NRCan), Canadian Spatial Reference System (CSRS)-PPP, by using single/dual-frequency Global Positioning System (GPS) data collected by dual-frequency geodetic-grade and Original Equipment Manufacturer (OEM) board type single-frequency GPS receivers. In this work, a kinematic test was carried out in Halic Bay (Golden Horn), Istanbul, Turkey, to assess the performance of the PPP method in a dynamic environment. Based on this study, it can be concluded that the coordinates estimated from the online CSRS-PPP service have a potential of about metre-level accuracy by processing single frequency data collected by an OEM receiver and about a decimetre to a few centimetres level accuracy by processing dual frequency data collected by a geodetic-grade receiver. In general, results show that the PPP technique has become a significant alternative to the conventional relative (differential) positioning techniques (i.e., Differential GPS (DGPS), Real-time Kinematic (RTK) ). The technique does not suffer from the drawbacks of the DGPS technique and has potential to provide the same position accuracy without the requirement for a reference station. Consequently, it has been concluded that the PPP technique may be effectively used in marine applications due to its ease of use and provision of high accuracy, as well as being able to offer reduced field operational costs. K E Y WO R D S 1. OEM GPS receiver.2. PPP. 3. Web-based service. 4. Marine applications.

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