Behavioural responses of young anaemic Indian Children to iron-folic acid supplements

Abstract

1. Behavioural responses of young anaemic Indian children to iron-folic acid supplements were assessed in two separate studies using the Indian adaptation of Wechsler's (1967) intelligence scale for children (WISC).2. The first study was an exploratory study in which the cognitive behaviour of 5-8-year-old children of both sexes was assessed before and after supplementation with 20 mg elemental Fe and 0.1 mg folic acid given daily for a period of 60 d.3. The supplemented children showed a significant improvement in haemoglobin (Hb) as well as the WISC scores while the control children who did not receive any supplements failed to show an improvement either in Hb or in the WISC scores. However, within the supplemented group when the initially-anaemic children were compared with the initially-non-anaemic ones, only the 7-year-old anaemic children performed significantly poorer in the tests than the non-anaemic group of the same age. The study raised the possibility that in addition to increasing the blood Hb levels, Fe-folic acid supplements may have additional benefits in improving the cognitive performance of children.4. In the second study, cognitive behaviour of fourteen matched pairs of anaemic children in the age-range of 5-6 years was assessed before and after supplementation with 40 mg Fe and 0.2 mg folk acid given daily in two divided doses or sugar placebos for a period of 60 d. The tester did not know the group to which each child belonged.5. The supplemented children showed a significant improvement in Hb as well as in the verbal and performance IQ of WISC. The control children showed no improvement in Hb but their verbal IQ improved significantly. However, there was no significant improvement in their performance IQ.6. The results indicated that Fe-folic acid supplements to anaemic children not only raised Hb levels but also improved intelligence'test results, particularly in the performance section.

Iron Deficiency and Schooling Attainment in Peru

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Developmental profile in children with iron deficiency anemia and its changes after therapeutic iron supplementation

“…Seshadri et al 23,24 from India, in 1982 conducted a series of studies. In one study, they evaluated 107 children, aged 5-8 year by Wechsler Intelligence Scale for Children (WISC).…”

Oral iron supplements for children in malaria-endemic areas

“…Experimental and observational studies have linked iron deficiency to adverse effects on child development, including impairments of cognitive, emotional, and motor development (Pollitt 1993; Grantham-McGregor 2001; Gewa 2009), growth (Lawless 1994), immune function, and increased risk of infection (Berger 2000; Beard 2001). The relative risk for mental retardation associated with a 1 g/dL increase in population mean haemoglobin level has been estimated at 0.78 (95% confidence interval (CI) 0.70 to 0.86) (WHO 2004).…”