Developmental profile in children with iron deficiency anemia and its changes after therapeutic iron supplementation

Gupta, Saurabh Kumar; Bansal, Deepak; Malhi, Prahbhjot; Das, Reena

doi:10.1007/s12098-010-0046-9

Cited by 21 publications

(15 citation statements)

References 19 publications

(25 reference statements)

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“…The study revealed that maximum cases were found in the age group of 6months to 3 years which is in concordance with observation made by various workers [16][17][18][19]. Considering the peculiar circumstances of diet, period of rapid and variable growth, lack of immunity and increased susceptibility to infections and effects of other extraneous influences on the haemopoietic system, anemia is quite common in infancy and early childhood.…”

Section: Discussionsupporting

confidence: 88%

Significance of Red Cell Distribution Width in the Diagnosis of Iron Deficiency Anemia: An Observational Study from India

Sharma¹

2015

JPNC

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Objective: To study the importance of Red cell distribution width (RDW) and peripheral smear in Iron Deficiency anemia (IDA) and its correlation with various RBC indices. Method and material: Hundred cases of microcytic (MCV <80fl) anemia (Hb<11 gm %), diagnosed as IDA were enrolled in the study, after getting parental consent. These children's were evaluated for clinical examination, red cell indices, RDW, serum iron and serum total iron binding capacity (TIBC) and transferrin saturation and peripheral blood film (PBF) examination for red cell morphology. Results: The mean RDW in mild, moderate and severe grade of iron deficiency anemia were 16.83±1.24, 18.52%+1.54 and 21.4%+3.15 respectively. The RDW was high in 98% cases of IDA.As the severity of IDA increased the values of RDW increased, serum iron decreased (p<0.001), TIBC increased (p<0.001) and serum transferrin saturation decreased (p<0.001). There was progressive decrease in MCV with increase in severity of anemia and there was corresponding increase in RDW. In mild IDA, the sensitivity of RDW was found to be very high (91%) in comparison to PBF changes (43.47%) cases and was statistically highly significant (p<0.001). In moderate IDA and severe IDA the sensitivity of RDW & PBF changes both were found to be very high. The positive predictive value of RDW and peripheral blood film changes was (100%) in all grades of IDA. The negative predictive value of RDW in mild grade of IDA was 88.23% as compared to 53.57% in PBF. In moderate grade of IDA, NPV of RDW was 100% as compared to 83% in case of PBF. While in severe grade of IDA the NPV of RDW and PBF was recorded to be 100%. Conclusion: The RDW was found to be highly sensitive and effective tool for early diagnosis of mild iron deficiency anaemia therefore; it is recommended that the RDW can be used as an effective tool for the diagnosis of iron deficiency anaemia in early stages, in a large number of samples at major hospitals thereby reducing manpower and time consumption.

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Section: Discussionsupporting

confidence: 88%

Significance of Red Cell Distribution Width in the Diagnosis of Iron Deficiency Anemia: An Observational Study from India

Sharma¹

2015

JPNC

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“…Studies indicate high correlations with the IQ calculated from DP II and from other conventional measures. The DP II has been used to measure the intelligence of children in India (Gupta et al 2010;Malhi and Singhi 2003;Malhi et al 2006).…”

Section: Methodsmentioning

confidence: 99%

Intelligence of Children from Economically Disadvantaged Families: Role of Parental Education

2010

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“…Anemia in infancy and early childhood is also associated with delayed development especially behavioural and cognitive delay and impaired learning and mental skills. A study by Gupta et al showed that children with iron deficiency anemia had suboptimal development score and this delayed development was variably reversible following iron therapy [15].…”

Section: Original Research Articlementioning

confidence: 99%

Study of anemia in hospitalised infants with special reference to its risk factors

Patel¹,

Patel²

2019

Int J Pediatr Res

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Background: Anemia is a major nutritional problem in India. Anemia in infancy and early childhood affects growth and development and is associated with increased morbidity and mortality. The aim of this study was to determine the prevalence, severity and types of anemia and study the risk factors for anemia in hospitalised infants. Methods: A prospective study was conducted at a tertiary care hospital in Western India from July 2016 to December 2017. Complete hemogram of all hospitalised infants between 6-12 months of age was done and those with haemoglobin levels<11g/dl were considered anemic. Results: Out of 206 hospitalised infants,131(63.6%) had anemia. Male: female ratio was1.3:1. The most common illness for which they were admitted was respiratory tract infections.35.1% of the anemic infants had low birth weight, 19.1% were born prematurely and 59.5% had a history of maternal anemia. Only 42% were exclusively breast fed till 6 months of age and improper complementary feeding practices was observed in 61.8% of infants. Mild, moderate and severe anemia was seen in 41.2%, 50.4% and 8.4% infants respectively. The most common type of anemia was microcytic hypochromic anemia (67.2%). Conclusion: Anemia is a major problem in infants with a high prevalence. Most infants have mild to moderate anemia and the most common type is microcytic hypochromic anemia most likely due to iron deficiency. Preterm gestation, absence of exclusive breastfeeding, consumption of cow's milk, improper complementary feeding practices and presence of maternal anemia were the risk factors found to be associated with development of anemia in the present study.

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Developmental profile in children with iron deficiency anemia and its changes after therapeutic iron supplementation

Abstract: Children with IDA have suboptimal developmental scores. The delayed development is variably reversible following oral iron therapy. Hb =< 7 g/dl and age >24 months predicts suboptimal outcome. FMD is a useful method of interpreting DPII.

Cited by 21 publications

References 19 publications

Significance of Red Cell Distribution Width in the Diagnosis of Iron Deficiency Anemia: An Observational Study from India

Significance of Red Cell Distribution Width in the Diagnosis of Iron Deficiency Anemia: An Observational Study from India

Intelligence of Children from Economically Disadvantaged Families: Role of Parental Education

Study of anemia in hospitalised infants with special reference to its risk factors

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