Behavioural Effects of Prenatal Exposure to Carbon Disulphide and to Aromatol in Rats

Lehotzky, K; Szeberényi, J. M.; Ungváry, G; Kiss, Anita

doi:10.1007/978-3-642-69928-3_100

Cited by 7 publications

(7 citation statements)

References 7 publications

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“…In summary, there was no evidence of developmental toxicity at the highest concentrations tested in either species. Lehotzky et al (1985aLehotzky et al ( , 1985b conducted a developmental neurotoxicity test with Aromatol as the test substance. As in the study by Ungvary and co-workers (Ungvary et al 1983, Ungvary andTatrai 1985), pregnant CFY rats were exposed 24 hours/day on gestational days 7-15.…”

Section: Developmental Toxicitymentioning

confidence: 99%

“…In a one-generation reproductive toxicity study (Lehotzky et al 1985a(Lehotzky et al , 1985b it was found that if dams were exposed continuously from days 7-15 of gestation to 120, 200 or 400 ppm (600, 1000, or 2000 mg/m 3 ) and then maintained without exposure until parturition, there were no significant differences in birth weight, postnatal gain or postnatal survival. Additionally, there were no apparent effects on nervous system development.…”

Section: Reproductive Toxicitymentioning

confidence: 99%

“…In repeated dose studies in animals, there is little if any evidence of systemic effects or pathological changes, but inflammatory responses in the respiratory tract have been observed (Carpenter et al 1977a, Clark et al 1989, Korsak et al 2000a, 2000b, Nau et al 1966, Swiercz et al 2000. In developmental toxicity tests, there was no evidence of malformations in studies which involved examination of the uterine contents or effects on the developing nervous system in studies in which offspring were examined at postnatal day 90, but developmental delays were observed at or above maternally toxic levels (Lehotzky et al 1985a, 1985b, McKee et al 1990, Saillenfait et al 2005, Ungvary et al 1983. Reproductive toxicity tests did not identify any effects on fertility (Lehotzky et al 1985a, McKee et al 1990).…”

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Characterization of the toxicological hazards of hydrocarbon solvents

McKee

Adenuga

Carrillo

2015

Critical Reviews in Toxicology

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Hydrocarbon solvents are liquid hydrocarbon fractions derived from petroleum processing streams, containing only carbon and hydrogen atoms, with carbon numbers ranging from approximately C5-C20 and boiling between approximately 35-370°C. Many of the hydrocarbon solvents have complex and variable compositions with constituents of 4 types, alkanes (normal paraffins, isoparaffins, and cycloparaffins) and aromatics (primarily alkylated one-and tworing species). Because of the compositional complexity, hydrocarbon solvents are now identified by a nomenclature ("the naming convention") that describes them in terms of physical/ chemical properties and compositional elements. Despite the compositional complexity, most hydrocarbon solvent constituents have similar toxicological properties, and the overall toxicological hazards can be characterized in generic terms. To facilitate hazard characterization, the solvents were divided into 9 groups (categories) of substances with similar physical and chemical properties. Hydrocarbon solvents can cause chemical pneumonitis if aspirated into the lung, and those that are volatile can cause acute CNS effects and/or ocular and respiratory irritation at exposure levels exceeding occupational recommendations. Otherwise, there are few toxicologically important effects. The exceptions, n-hexane and naphthalene, have unique toxicological properties, and those solvents containing constituents for which classification is required under the Globally Harmonized System (GHS) are differentiated by the substance names. Toxicological information from studies of representative substances was used to fulfill REACH registration requirements and to satisfy the needs of the OECD High Production Volume (HPV) initiative. As shown in the examples provided, the hazard characterization data can be used for hazard classification and for occupational exposure limit recommendations. Introduction Scope and purpose of the documentThe present document summarizes information on the physical/ chemical properties and toxicological hazards of hydrocarbon solvents and provides examples of the ways in which the information on hazard characterization can be used for hazard classification and to set occupational exposure limits. Many of the toxicological studies were published separately, but the results are summarized herein and referenced in the appendices.Hydrocarbon solvents are liquid hydrocarbon fractions that are primarily produced by the distillation of petroleum feed stocks or their synthetic analogs (e.g., Fischer-Tropsch derived materials), sometimes followed by additional processing steps such as solvent extraction, hydrodesulfurization, or hydrogenation. 1 Most hydrocarbon solvents are complex substances with variable compositions and are best described as UVCB 2 (unknown and variable composition) substances, but some are single constituent (mono-constituent) substances. The complex and variable nature of these solvents is the consequence of their manufacturing processes. In short, most hydroca...

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Section: Developmental Toxicitymentioning

confidence: 99%

Section: Reproductive Toxicitymentioning

confidence: 99%

mentioning

confidence: 99%

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Characterization of the toxicological hazards of hydrocarbon solvents

McKee

Adenuga

Carrillo

2015

Critical Reviews in Toxicology

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“…The authors reported delayed eye opening and auditory function as well as impaired exploratory or motor activity in the open-field test in pups from 10 mg/m 3 . In Lehotzky et al (1985), female rats were exposed by inhalation to 10, 700, or 2000 mg/m 3 CS 2 from gestational days 7 to 15, 6 h per day by inhalation [ 49 ]. Reduced mean pup weight, delayed eye opening and immature righting reflex were observed at PND 21 particularly at the two highest doses.…”

Section: Resultsmentioning

confidence: 99%

“…TH disruption can also induce sensorimotor alterations, such as the those observed in some studies following CS 2 exposure during development [ 46 , 47 , 48 , 49 ]. To date, there is no AOP linking TPO inhibition or thyroid disruption during development to adverse motor dysfunction, but a causal relationship remains plausible.…”

Section: Resultsmentioning

confidence: 99%

How to Differentiate General Toxicity-Related Endocrine Effects from Endocrine Disruption: Systematic Review of Carbon Disulfide Data

Printemps

Magueresse-Battistoni

Mhaouty-Kodja

et al. 2022

IJMS

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This review provides an overview of the assessment of the endocrine disrupting (ED) properties of carbon disulfide (CS2), following the methodology used at the European level to identify endocrine disruptors. Relevant in vitro, in vivo studies and human data are analyzed. The assessment presented here focuses on one endocrine activity, i.e., thyroid disruption, and two main adverse effects, neurotoxicity and cardiotoxicity. The data available on the different ED or non-ED modes of action (MoA), known to trigger these adverse effects, are described and the strength of evidence of the different MoA is weighted. We conclude that the adverse effects could be due to systemic toxicity rather than endocrine-mediated toxicity. This assessment illustrates the scientific and regulatory challenges in differentiating a specific endocrine disruption from an indirect endocrine effect resulting from a non-ED mediated systemic toxicity. This issue of evaluating the ED properties of highly toxic and reactive substances has been insufficiently developed by European guidance so far and needs to be further addressed. Finally, this example also raises questions about the capacity of the technics available in toxicology to address such a complex issue with certainty.

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Sammelkapitel MAK‐Werte und Schwangerschaft [MAK Value Documentation in German language, 1992]

2012

The MAK‐Collection for Occupational Health and Safety

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Behavioural Effects of Prenatal Exposure to Carbon Disulphide and to Aromatol in Rats

Cited by 7 publications

References 7 publications

Characterization of the toxicological hazards of hydrocarbon solvents

Characterization of the toxicological hazards of hydrocarbon solvents

How to Differentiate General Toxicity-Related Endocrine Effects from Endocrine Disruption: Systematic Review of Carbon Disulfide Data

Sammelkapitel MAK‐Werte und Schwangerschaft [MAK Value Documentation in German language, 1992]

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