Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse

Soulimani, Rachid; Younos, C.; Jarmouni, Salah; Bousta, Dalila; Misslin, René; Mortier, F.

doi:10.1016/s0378-8741(97)00042-1

Cited by 151 publications

(111 citation statements)

References 19 publications

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“…1): Orientin (Luteolin-8-C-glucoside), Isoorientin (Luteolin-6-Cglucoside), Isovitexin (Apigenin-6-C-glucoside), and Vitexin (Apigenin-8-C-glucoside), first isolated from bamboo leaves, all of which are also found in numerous plants. 2,3) It is reported that these flavonoids possess anxiolytic properties 4,5) and that Orientin possesses antioxidative activity, 6) however, there is no information about the vasorelaxant effect of these compounds. In the present investigation, we examined the vasodilatation effects of these flavonoid C-glycosyl compounds and found only Orientin produced a vasorelaxant effect on rabbit aortic rings.…”

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confidence: 99%

Vasodilatation Produced by Orientin and Its Mechanism Study

Wang

et al. 2005

Biological & Pharmaceutical Bulletin

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Bamboo leaves, Phyllostachys nigra (LODD. ex. lind-1 MUNRO. L), have been used as a Chinese medicament for thousands of years. Theses leaves have anti-free radical activity and are comparable with the leaf of Ginkgo bilabo, which is one potential resource for natural antioxidant and free radical scavenger. 1) Our previous investigation revealed that bamboo leaves have significant effects on protecting myocardial ischemia in rat, restraining blood platelet aggregation of rabbit, increasing coronal flow and have a vasorelaxant effect on rabbit thoracic aortic rings, and also reduce arterial blood pressure. Here, we further investigated the vasorelaxant effect of four flavonoid C-glycosyl compounds ( Fig. 1): Orientin (Luteolin-8-C-glucoside), Isoorientin (Luteolin-6-Cglucoside), Isovitexin (Apigenin-6-C-glucoside), and Vitexin (Apigenin-8-C-glucoside), first isolated from bamboo leaves, all of which are also found in numerous plants. 2,3) It is reported that these flavonoids possess anxiolytic properties 4,5) and that Orientin possesses antioxidative activity, 6) however, there is no information about the vasorelaxant effect of these compounds. In the present investigation, we examined the vasodilatation effects of these flavonoid C-glycosyl compounds and found only Orientin produced a vasorelaxant effect on rabbit aortic rings. The data from the present study suggested that Orientin relaxed thoracic aortic rings by the nitric oxide-guanosine 3,5-cyclic monophosphate (cGMP) pathway, and in the vascular smooth muscle inhibited the contraction induced by the activation of receptor-operating and voltage-dependent Ca 2ϩ channels. Cyclooxygenase pathway, potassium channels, b-receptors and adenosine-3Ј,5Ј-cyclic phosphoric acid (cAMP) pathway, on the other hand, had no apparent roles. The inhibition of both intracellular Ca 2ϩ release and extracellular Ca 2ϩ influx may be one of the main vasorelaxant mechanisms of Orientin. MATERIALS AND METHODS Animal

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confidence: 99%

Vasodilatation Produced by Orientin and Its Mechanism Study

Wang

et al. 2005

Biological & Pharmaceutical Bulletin

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“…Patients treated with passionflower reported fewer adverse effects than those receiving the synthetic anxiolytic (Akhondzadeh and Nazirian, 2001a,b). In animal experiments, Soulimani et al (1997) also reported that the aqueous extract of passiflora incarnata caused a decrease of rearing and locomotion in the staircase apparatus or exploratory test. Recently, Svenningsen et al, (2006) have found that apigenin, an active ingredient of passionflower, binds to central benzodiazepine receptors, possibly causing anxiolytic effects without impairing memory or motor skills.…”

Section: Passionflower (Passiflora Incarmata)mentioning

confidence: 96%

Risks and benefits of commonly used herbal medicines in Mexico

Rodríguez‐Fragoso

Reyes‐Esparza

Burchiel

et al. 2008

Toxicology and Applied Pharmacology

166

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In Mexico, local empirical knowledge about medicinal properties of plants is the basis for their use as home remedies. It is generally accepted by many people in Mexico and elsewhere in the world that beneficial medicinal effects can be obtained by ingesting plant products. In this review, we focus on the potential pharmacologic bases for herbal plant efficacy, but we also raise concerns about the safety of these agents, which have not been fully assessed. Although numerous randomized clinical trials of herbal medicines have been published and systematic reviews and meta-analyses of these studies are available, generalizations about the efficacy and safety of herbal medicines are clearly not possible. Recent publications have also highlighted the unintended consequences of herbal product use, including morbidity and mortality. It has been found that many phytochemicals have pharmacokinetic or pharmacodynamic interactions with drugs. The present review is limited to some herbal medicine that are native or cultivated in Mexico and that have significant use. We discuss the cultural uses, phytochemistry, pharmacological and toxicological properties of the following following plant species: Nopal (Opuntia ficus), Peppermint (Mentha piperita), Chaparral (Larrea divaricata), Dandlion (Taraxacum officinale), Mullein (Verbascum densiflorum), Chamomile (Matricaria recutita), Nettle or Stinging Nettle (Urtica dioica), Passionflower (Passiflora incarmata), Linden Flower (Tilia europea), and Aloa (Aloa vera). We conclude that our knowledge of the therapeutic benefits and risks of some herbal medicines used in Mexico is still limited and efforts to elucidate them should be intensified.

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“…Some reports have pointed out the Harman alkaloids as the bioactive constituents of Passiflora incarnata Linn, one of the species of Passiflora that have been extensively studied chemically and biologically. Harman, important alkaloid was found to be present in P. foetida [21,23,24]. …”

Section: Chemistry Of P Foetidamentioning

confidence: 99%

Passiflora foetida L: An Exotic Ethnomedicinal Plant of Odisha, India

Patra¹

2016

J.Pharm Pharm Scien

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Passiflora foetida (Passifloraceae), known as Stinking Passion Flower, is an herbaceous climber that is found throughout the Odisha state of India. It has been widely used in traditional medicine of the state for the treatment of different types of diseases and disorders. It has rich pharmacological values particularly in mental disorder and possesses numerous bioactive compounds such as vitexin, luteolin, apigenin, etc., which may be responsible for its bacteriocidal, antidysentric, antilithicand other effects. Keeping its richness in the state of Odisha and reported pharmacological values, an attempt has been made to document some common uses of this vine among the rural and tribal communities of the state through the field survey for collection of ethnobotanical values. In addition, extensive literature survey was carried out to highlights the sound pharmacological values of P. foetida L.

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Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse

Cited by 151 publications

References 19 publications

Vasodilatation Produced by Orientin and Its Mechanism Study

Vasodilatation Produced by Orientin and Its Mechanism Study

Risks and benefits of commonly used herbal medicines in Mexico

Passiflora foetida L: An Exotic Ethnomedicinal Plant of Odisha, India

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