Behavioural changes after an acute stress: stressor and test types influences

Mercier, Sarah; Frederic,; Canini,; Buguet, Alain; Cespuglio, Raymond; Martin, Sheree D.; Bourdon, Lionel

doi:10.1016/s0166-4328(02)00265-6

Cited by 62 publications

(26 citation statements)

References 39 publications

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“…In females, feeding and drinking differed significantly between the breeds over time, where RJF showed an immediate behaviour change followed by a fairly rapid return to baseline, while the effects were more subtle in WL. In rodents, decreased feeding can be caused by both repeated [35] and acute stress [38], and time to retain normal feeding has been found to vary dependent on type and intensity of the stressor [33,38,48]. Foraging behaviour in the WL did not revert to baseline during the entire hour after stress, while in RJF it did so faster, and even increased over baseline after 10-15 minutes.…”

Section: Discussionmentioning

confidence: 94%

Domestication effects on behavioural and hormonal responses to acute stress in chickens

Ericsson

Fallahsharoudi

Bergquist

et al. 2014

Physiology & Behavior

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Comparative studies have shown that alterations in physiology, morphology and behaviour have arisen due to the domestication. A driving factor behind many of the changes could be a shift in stress responses, with modified endocrine and behavioural profiles. In the present study we compared two breeds of chicken (Gallus gallus), the domestic White Leghorn (WL) egg laying breed and its ancestor, the Red Junglefowl (RJF). Birds were exposed to an acute stress event, invoked by three or ten minutes of physical restraint. They were then continuously monitored for the effects on a wide range of behaviours during a 60 min recovery phase. Blood samples were collected from the chicken at baseline, and after 10 and 60 min following a similar restraint stress, and the samples were analyzed for nine endogenous steroids of the HPA and HPG axis. Concentration of the steroids was determined using validated liquid chromatography tandem mass spectrometry methods. In RJF, an immediate behavioural response was observed after release from restraint in several behaviours, with a relatively fast return to baseline within one hour. In WL, some behaviours were affected for a longer period of time, and others not at all. Concentrations of corticosterone increased more in RJF, but returned faster to baseline compared to WL. A range of baseline levels for HPG-related steroids differed between the breeds, and they were generally more affected by the stress in WL than in RJF. In conclusion, RJF reacted stronger both behaviourally and physiologically to the restraint stress, but also recovered faster. This would appear to be adaptive under natural conditions, whereas the stress recovery of domesticated birds has been altered by domestication and breeding for increased reproductive output.

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Section: Discussionmentioning

confidence: 94%

Domestication effects on behavioural and hormonal responses to acute stress in chickens

Ericsson

Fallahsharoudi

Bergquist

et al. 2014

Physiology & Behavior

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“…Secondly, the FST may have exerted a different stress exposure than blood sampling under restraint used as postnatal stressor in previous studies [Hougaard et al, 2005a, b;Kjaer et al, 2010]. The FST has been compared with restraint stress among other stress forms [Bowers et al, 2008;Mercier et al, 2003]. These studies used duration of increased HPA axis activity in the form of plasma or serum corticosterone (CORT) levels and core temperature changes (among others) as measures for stress intensity.…”

Section: Discussionmentioning

confidence: 99%

Reduced Mobility But Unaffected Startle Response in Female Rats Exposed to Prenatal Dexamethasone: Different Sides to a Phenotype

et al. 2010

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An adverse fetal environment is strongly associated with behavioral and emotional development in later life, and environmental interactions with the genome are essential in the development of pathophysiology. This implicates that a genetic vulnerability or other predisposition may interact with the environment and stressful life events to trigger mental disease. The startle reflex is highly sensitive to fear and anxiety in humans and animals. Elevated startle magnitude has been proposed as a marker for neurodevelopmental disorders. We have recently established an animal model for possible development of anxiety, where female rats are exposed to two stressful life events, during prenatal life and as adolescents, respectively. A blood sampling procedure 3 months prior to startle testing has previously been found to increase basal startle, but only in prenatally stressed rats. As the experimental procedure of acoustic startle response (ASR) measurement resembles the aversive blood sampling procedure, this suggests that effects on ASR may be caused by aversive contextual similarities between blood sampling under restraint and the ASR test. In the present study, postnatal blood sampling was replaced by another dissimilar stressful event. Animals exposed to a high prenatal glucocorticoid level (i.e. 150 µg dexamethasone/kg) were statistically significantly more immobile in the forced swim test (FST) than animals exposed to a lower level of dexamethasone (50 µg/kg) and control animals. Exposure to a novel contextual stressor at 3 months of age (FST) was unassociated with changes in basal startle. These data suggest, since the high prenatal dexamethasone group showed increased immobility in the FST but coped equally well with controls in the ASR, that the outcome of environmental influences is determined by the individual circumstances as different situations require different coping abilities in the same individual.

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“…Chronic mild restraint was used as a model to induce psychological stress [26,27,28]. Animals were placed in a transparent Plexiglas container (5 cm inner diameter) for a period of 20 min/day.…”

Section: Animals and Methodsmentioning

confidence: 99%

“…The open field task was used as a measure of general locomotor and exploratory activity in stressed rats [28]. …”

Section: Animals and Methodsmentioning

confidence: 99%

Blockade of Mineralocorticoid and Glucocorticoid Receptors Reverses Stress-Induced Motor Impairments

Jadavji

Supina²,

Metz³

2011

Neuroendocrinology

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Aim: Stress and glucocorticoids can influence movement performance and pathologies of the motor system. The classic notion assumes that the glucocorticoid receptor (GR) mediates the majority of stress-induced behavioral changes. Nevertheless, recent findings have attributed a more prominent role to the mineralocorticoid receptor (MR) in modulating behavior. The purpose of this study was to dissociate the impact of MR versus GR activation in movement and stress-associated motor disruption. Methods: Groups of male and female rats were tested in skilled reaching and open field behavior and treated peri-orally with either agonists or antagonists for MR and GR, respectively. Results: Selective acute activation of MR (aldosterone) and GR (dexamethasone) decreased movement success with a magnitude similar to stress-induced impairment in male and female animals. By contrast, antagonist treatment to block MR (RU-28318) or GR (Mifepristone, RU-486) prevented motor impairments caused by acute restraint stress or corticosterone treatment. Moreover, both antagonists reversed chronic stress- and glucocorticoid-induced motor impairments to values comparable to baseline levels. Higher success rates in treated animals were accompanied by improved performance of skilled limb movements. In addition, combined treatment with MR and GR antagonists had additive benefit on aim and advance towards the reaching target. Conclusion: These observations suggest that MR or GR equally influence motor system function with partially synergistic effects. Males and females show comparable responses to MR and GR activation or blockade. The need for balanced activation of MRs and GRs in motor control requires consideration in intervention strategies to improve performance in health and disease.

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Behavioural changes after an acute stress: stressor and test types influences

Cited by 62 publications

References 39 publications

Domestication effects on behavioural and hormonal responses to acute stress in chickens

Domestication effects on behavioural and hormonal responses to acute stress in chickens

Reduced Mobility But Unaffected Startle Response in Female Rats Exposed to Prenatal Dexamethasone: Different Sides to a Phenotype

Blockade of Mineralocorticoid and Glucocorticoid Receptors Reverses Stress-Induced Motor Impairments

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