Behavioural and psychological symptoms in neurocognitive disorders: Specific patterns in dementia subtypes

Majer, Réka; Simon, Viktória; Csiba, László; Kardos, Lászĺo; Frecska, Ede; Hortobágyi, Tibor

doi:10.1515/med-2019-0028

Cited by 26 publications

(18 citation statements)

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“…In our previous publication, the relationship between cognitive function and NPS was analysed in detail [ 18 ]. Therefore, this study’s focus is particularly on the relationship between NPS and quality of life, illness intrusiveness and caregiver’s burden.…”

Section: Resultsmentioning

confidence: 99%

“…With respect to individual symptoms, based on frequency scores, abnormal motor behaviours (2.7 [SD = 1.2]), depression (1.8 [SD = 1.2]), agitation (1.7 [SD = 1.2]) and eating-appetite change (1.4 [SD = 1.3])were the most frequent in the total sample. The relationship between cognitive function and NPS is described in detail in our previously published article, "Behavioural and psychological symptoms in neurocognitive disordersspecific patterns in dementia subtypes"[18].…”

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confidence: 99%

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Neuropsychiatric symptoms, quality of life and caregivers’ burden in dementia

et al. 2020

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The objective of this research is to identify the relationship between the neuropsychiatric symptoms (NPSs) of patients with major neurocognitive disorder (mNCD), their quality of life, illness intrusiveness and the caregiver’s burden. We assessed 131 patients with mNCD. Examination methods included WHO well-being index short version, illness intrusiveness rating scale, Alzheimer’s Disease Assessment Scale-Cog, Mini Mental State Examination and neuropsychiatric inventory. The results were analysed using standard statistical tests. In our sample, the prevalence of NPSs is 100%. A significant correlation (p < 0.0001) was observed with quality of life and illness intrusiveness. Additionally, a strong relationship was observed between NPSs and the caregiver’s burden (r = 0.9). The result is significantly twice as much stronger in comparison to the relationship between NPS and cognitive symptoms (r = 0.4). This is the first study in Hungary to assess the impact of NPS on the burden of relatives and quality of life. NPS had twice stronger impact on caregivers’ burden than cognitive decline. However, further studies are needed to assess the sub-syndromes in mNCD in relation to NPS.

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confidence: 99%

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Neuropsychiatric symptoms, quality of life and caregivers’ burden in dementia

et al. 2020

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“…On the other hand, certain degree of cognitive impairment may bias assessment of depressive symptoms, including that made by the BDI, through hindering the capacity of understanding the questions properly and of correct recollection of memories for the answers, or just simply not being able to concentrate long enough for a task [20]. The study of Majer et al [21] further underlined neccessity to be cautious when interpreting changes in cognition and mood of patients with metabolic syndrome and CSVD, as it demonstrated that worse cognitive functions in patients with dementia were related to higher frequency and greater severity of symptoms related to depression, like apathy, irritability, sleep-wake cycle dysfunctions and changes of appetite.…”

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confidence: 99%

Suffering from cerebral small vessel disease with and without metabolic syndrome

et al. 2019

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AbstractBackgroundCerebral small vessel disease (CSVD) and metabolic syndrome were separately associated with cognitive impairment and depression. However, whether metabolic syndrome adds to cognitive impairment and depression in patients who already have CSVD remained unanswered.ObjectiveThe aim of our study was to investigate the association of metabolic syndrome with cognitive impairment and depression in patients with CSVD who have lacunar lesions or white matter hyperintensities.MethodsThis prospective cohort study was conducted at Neurology Clinic, Clinical Center, Kragujevac, Serbia. Main outcomes of the study were cognitive assessment, and assessment of depression among hospitalized patients with or without CSVD.ResultsThe study included 74 inpatients, 25 of them having lacunary infarctions, 24 with the white matter hyperintensities, and 25 control patients without CSVD. The CSVD was accompanied by impairment of cognition and depression, the patients with lacunary lesions being more cognitively impaired and more depressive than the patients with the white matter hyperintensities. The patients with CSVD who also had metabolic syndrome were more cognitively impaired and depressed than the patients with CSVD alone.ConclusionsIn conclusion, our study showed that metabolic syndrome is associated with further worsening of already impaired cognition and existing depression in patients with CSVD.

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“…Результаты исследования R. Majer и соавт. [25] показали, что не только подтип деменции, но и уровень когнитивных нарушений связан с частотой и тяжестью некоторых НПС. Утяжеление когнитивного функционирования коррелирует с более высокой частотой и большей выраженностью апатии, раздражительности, нарушениями цикла сна и бодрствования, изменениями аппетита, аномальным двигательным поведением и расторможенностью.…”

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Neuropsychiatric Symptoms and Antipsychotic Therapy in the Elderly Patients with Dementia

Колыхалов¹

2020

Psychiatry

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The objective of the study was to investigate syndromal-nosological specificities of neuropsychiatric symptoms (NPS) and the frequency of use of antipsychotics in patients with various types of dementias, institutionalized to geriatric units of mental hospitals.Patients and methods: a total of 106 in-patients of three psychogeriatric units were examined. The median age of patients is 75 years [69; 80].The diagnostic distribution of patients at the time of the examination was as follows: in 33 subjects (31.1%) Alzheimer’s disease (AD) was diagnosed, in 25 (23.6%) - mixed dementia (MD), in 32 (30.2%) - vascular dementia (VD) and in 16 (15.1%) patients had dementia of complex origin (DCO).Results: a high incidence (54.7%) of NPS was found in patients with dementia of various origins. The greatest number of patients with behavioral and psychotic symptoms was found in AD and MD. The proportion of dementia patients with such disorders in each of these types of dementia is about 70%, while in CGD and VD, the proportion of patients with NPS is noticeably smaller (30% and 40%, respectively). For the treatment of NPS, antipsychotics were most often prescribed, but their use caused adverse events (AEs) in 1/3 of cases. Patients with VD are most susceptible to the development of AE, and AD patients are the least susceptible.Conclusion: the study showed that NPS are one of the important components of dementia, regardless of the nosology and stage of the disease. The treatment of NPS in dementia is particularly challenging because, although the symptoms cause significant distress, there are currently no effective alternative therapies. The risk of AE can be minimized by carefully considering the indications for prescribing antipsychotics and their short-term use, regular monitoring of the patient’s condition, and educating caregivers.

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Behavioural and psychological symptoms in neurocognitive disorders: Specific patterns in dementia subtypes

Cited by 26 publications

References 33 publications

Neuropsychiatric symptoms, quality of life and caregivers’ burden in dementia

Neuropsychiatric symptoms, quality of life and caregivers’ burden in dementia

Suffering from cerebral small vessel disease with and without metabolic syndrome

Neuropsychiatric Symptoms and Antipsychotic Therapy in the Elderly Patients with Dementia

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