Neuropsychiatric symptoms, quality of life and caregivers’ burden in dementia

Majer, Réka; Adeyi, Olar; Bagoly, Zsuzsa; Simon, Viktória; Csiba, László; Kardos, Lászĺo; Hortobágyi, Tibor; Frecska, Ede

doi:10.1515/med-2020-0124

Cited by 12 publications

(12 citation statements)

References 37 publications

(33 reference statements)

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“…We found that NPS was associated with CB and there was a statistically significant relationship between all subcomponents of CB and NPS. The results of this study are in line with previous findings showing that the presence of NPS in people with AD is associated with both increased burden and lower quality of life in caregivers (37). Also, in the study by Chen et al, the results showed that NPI score was independently associated with mean NPI-burden score (38).…”

Section: Discussionsupporting

confidence: 91%

Neuropsychiatric Symptoms of Alzheimer's Disease and Caregiver Burden

Iravani

Abdollahi

Eslamdoust-Siahestalkhi

et al. 2022

Front. Neurol.

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Introduction/ObjectivesIn addition to cognitive decline, one of the most important problems for caregivers of patients with Alzheimer's is neuropsychiatric symptoms (NPS). This study aimed to evaluate the NPS in patients with Alzheimer's disease (AD) and investigate its relationship with caregiver burden (CB).MethodsIn a cross-sectional study of 85 patients with AD referred to Shafa Hospital in Rasht and their caregivers in 2020, information was collected using a demographic questionnaire, Neuropsychiatric Inventory Questionnaire (NPI-Q), and the Caregiver Burden Inventory (CBI). Data were analyzed by Spearman correlation, t-test, and linear regression, with SPSS version 22.ResultsThe mean age of the patients and their caregivers were 74.95 ± 8.87 years and 43.98 ± 11.38 years, respectively. The mean total score of NPS in patients with AD was 44.25 (0–144) and the mean CB score was 36.27 (0–96), which was a moderate level. According to the results, 91% of patients had apathy, while happiness/euphoria was reported as the most uncommon symptom. In addition, there was a significant relationship between the score of NPS and CB (r = 0.542, P < 0.0001), as well as all its sub-components, time-dependence burden with more correlation (r = 0.509, P < 0.0001), and social burden with less correlation (r = 0.352, P < 0.001). NPS, hallucination, aberrant motor behavior (AMB), delusion, and depression were most correlated with CB. Also, the mean score of CB was significantly higher in women than in men (P = 0.045). Living in a rural area had a significant relationship with NPS score (P = 0.026). Also, linear regression showed that with increasing 1 year of patients' age, the mean score of patient's NPS decreased by 0.374 (P = 0.048).ConclusionNeuropsychiatric symptoms, especially hallucination, aberrant motor behavior (AMB), delusion, and depression were associated with caregiver burden. Apathy was the most common symptom in patients with AD.

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Section: Discussionsupporting

confidence: 91%

Neuropsychiatric Symptoms of Alzheimer's Disease and Caregiver Burden

Iravani

Abdollahi

Eslamdoust-Siahestalkhi

et al. 2022

Front. Neurol.

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“…More importantly; our study is, to our knowledge, the first to investigate and find predictive links between premorbid maladaptive personality traits and the emotional distress of the caregiver associated with different BPSD. Our outcomes are highly relevant for clinical practice as little is known about BPSD, which are one of the main reasons of earlier institutionalization and create a great distress on the patient and their context 2 …”

Section: Discussionmentioning

confidence: 99%

“…Most patients with dementia suffer from at least one feature of BPSD 2 . BPSD can create a great distress on patient and caregiver 4 .…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to the cognitive symptoms, little is known about the non‐cognitive symptoms of dementia, also described as behavioural and psychological symptoms in dementia (BPSD). These symptoms can occur in any stage and any subtype of the disease with varying frequency and severity 2 . Over 96.6% of nursing home residents with dementia are found to suffer from at least one BPSD symptom during the course of their disease 3 .…”

Section: Introductionmentioning

confidence: 99%

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The role of maladaptive personality in behavioural and psychological symptoms in dementia

Dero,

van Alphen,

Hoogenhout

et al. 2023

Int J Geriat Psychiatry

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Background Although research demonstrated a significant link between premorbid normative personality traits and the severity of behavioural and psychological symptoms in dementia (BPSD) and associated emotional distress of the caregiver, little is known about the relationship of BPSD symptoms and associated distress with maladaptive traits. Method Informants (N = 182) of Dutch nursing home residents with dementia aged 65+, completed the Neuropsychiatric Inventory Questionnaire to assess the severity of BPSD and associated emotional distress. Premorbid maladaptive personality traits were evaluated using informant versions of a brief version of the Personality Inventory for Diagnostic and Statistical manual of Mental Disorders‐5 (PID‐5‐BF), and two age‐specific personality measures, the Informant Personality Questionnaire (HAP), and Gerontological Personality disorder Scale. Relationships between premorbid personality and BPSD were investigated with correlational and ordinal regression analyses. Results BPSD severity and distress were associated with medium sized correlations to Negative Affectivity, Antagonism and indications of personality disorder presence. The emotional distress also correlated with a medium effect with Detachment. Higher scores on maladaptive personality traits increased the odds of higher BPSD severity and distress. Conclusion Results found with age‐specific personality measures were in line with results found with other measures of (mal)adaptive traits. Several maladaptive personality traits had a significant relationship with the BPSD severity and associated emotional distress. We therefore encourage to implement personality assessment within BPSD treatment strategies. This way care becomes more person‐focused and more tailored to the specific needs of patients and caregivers.

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“…Approximately 20%−30% of Americans and 8% of Chinese in the elderly population have health issues related to cognitive impairment [1]. Abnormal cognitive functioning impedes the quality of life and affects the disease burden for caregivers as well as patients [2]. It is more likely to further develop into worse impairments, such as Alzheimer's disease or dementia, and increase the risk of morbidity and mortality [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Association between Serum Lipid Parameters and Cognitive Performance in Older Adults

Lee

Min

et al. 2021

JCM

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(1) Background: Previous studies have suggested the association between lipid profiles and cognitive function in older adults. However, they generated inconsistent results. We aim to determine the relationship between lipid profiles and cognitive performance in older adults. (2) Methods: We used the 2011–2014 National Health and Nutrition Examination Survey. This study included 2215 participants who were aged more than 60 years old and free of coronary heart disease or stroke. Lipid profiles included total cholesterol (TC), low density lipid cholesterol (LDL), high density lipid cholesterol (HDL), and triglyceride (TG). Cognitive function was assessed using the digit symbol substitution test (DSST). (3) Results: Positive correlations of DSST were observed with TC (r = 0.111; p < 0.0001), HDL (r = 0.127; p < 0.0001), and LDL (r = 0.107; p = 0.0005). However, there was no significant relationship between TG and DSST. A one-unit increase in HDL was associated with an increase in DSST score (beta coefficient: 0.036; p = 0.018); but the association was not significant for LDL, TG, and TC. In the categorical analysis, the high HDL group had a higher DSST score than the low HDL group (beta = 3.113; p < 0.0001) and the low TG group was more likely to show a lower DSST score than the high TC group (beta = −1.837; p = 0.0461). However, LDL and TC showed no statistically significant associations. Moreover, HDL was only associated with a 0.701 times increased risk of cognitive impairment (95% CI = 0.523–0.938) in the logistic regression analysis. (4) Conclusions: Higher blood concentrations of HDL levels were positively associated with DSST scores in older adults. We suggest that the high levels of HDL may be a protective factor against cognitive impairment.

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Neuropsychiatric symptoms, quality of life and caregivers’ burden in dementia

Cited by 12 publications

References 37 publications

Neuropsychiatric Symptoms of Alzheimer's Disease and Caregiver Burden

Neuropsychiatric Symptoms of Alzheimer's Disease and Caregiver Burden

The role of maladaptive personality in behavioural and psychological symptoms in dementia

Association between Serum Lipid Parameters and Cognitive Performance in Older Adults

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