Behavioural and immunological effects of the antihistamine terfenadine in olfactory bulbectomized rats

Song, Cai; Earley, Bernadette; Leonard, Brian E.

doi:10.1016/0924-977x(95)00073-x

Cited by 22 publications

(8 citation statements)

References 29 publications

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“…Noguchi et al (1992) have found that forced swimming increases histamine function and that histamine H 1 receptor antagonists such as mepyramine reduce immobility, which is just the opposite to the findings of Lamberti et al (1998). In another model of depression, the olfactory bulbectomized rat, the histamine H 1 receptor antagonist terfenadine also showed an antidepressant-like effect (Song et al 1996). Alternatively, the putative antidepressant properties of thioperamide may reside in a histamine H 3 heteroreceptor-mediated stimulation of the release of other neurotransmitters, mainly on its proved ability to increase the central levels of noradrenaline (Schlicker et al 1994) and serotonin (Schlicker et al 1988).…”

Section: Discussionmentioning

confidence: 88%

Effects of histamine H 3 receptor ligands in experimental models of anxiety and depression

Pérez-Garcı́a¹,

Morales²,

Mv³

et al. 1999

Psychopharmacology

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Histamine H3 receptor ligands have been proposed to be of potential therapeutic interest for the treatment of different central nervous system disorders; however, the psychopharmacological properties of these drugs have not been studied extensively. In this work, we investigated the possible involvement of histamine H3 receptor function in experimental models of anxiety (elevated plus-maze) and depression (forced swimming test). Male Sprague-Dawley rats were treated i.p. with the histamine H3 receptor agonist R-alpha-methylhistamine (10 mg/kg) or the histamine H3 receptor antagonist thioperamide (0.2, 2 and 10 mg/kg) and 30 min afterwards the time spent in the open arms of an elevated plus-maze was registered for 5 min. The immobility time of male OF1 mice in the forced swimming test was recorded for 6 min, 1 h after the i.p. administration of R-alpha-methylhistamine (10 and 20 mg/kg), thioperamide (0.2, 2, 10 and 20 mg/kg) or another histamine H3 receptor antagonist, clobenpropit (5 mg/kg). The locomotor activity of mice was checked in parallel by means of an activity meter. Both saline controls and active drug controls were used in all the paradigms. Neither thioperamide nor R-alpha-methylhistamine significantly changed animal behaviour in the elevated plus-maze. R-alpha-methylhistamine and the higher dose of thioperamide assayed (20 mg/kg) were also inactive in the forced swimming test. By contrast, thioperamide (0.2-10 mg/kg) dose-dependently decreased immobility, the effect being significant at 10 mg/kg (33% reduction of immobility); clobenpropit produced an effect qualitatively similar (24% reduction of immobility). None of these histamine H3 receptor antagonists affected locomotor activity. These preliminary results suggest that the histamine H3 receptor blockade could be devoid of anxiolytic potential but have antidepressant effects. Besides, the stimulation of these receptors does not seem to be followed by changes in the behavioural parameters studied.

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Section: Discussionmentioning

confidence: 88%

Effects of histamine H 3 receptor ligands in experimental models of anxiety and depression

Pérez-Garcı́a¹,

Morales²,

Mv³

et al. 1999

Psychopharmacology

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“…Because monocytes, as resting macrophages, do not produce detectable chemineluminescence, the phorbol 12-myristate 13-acetate (PMA)-induced chemiluminescence of monocytes/ macrophages was performed by our previously published method (Song et al, 1996). Different concentrations of PMA were tested and the optimal concentration 100 g/ml was selected.…”

Section: Measurements Of Macrophage Activity and Lymphocyte Proliferamentioning

confidence: 99%

“…In In the present study, different concentrations of PHA (Sigma, Canada) and Con A (Sigma, Canada) were tested, and optimal concentrations of PHA (10 g/ml) and Con A (5 g/ml) were selected before carrying out the formal experiment. The cell culture procedure was the same as described before (Song et al, 1996). In brief, 200 l of RPMI-1640 medium that contained PHA or ConA were added to a 96 well plate with lymphocytes (triplicate for each subject) at 37 o C in a 5% CO 2 atmosphere for 64 hours.…”

Section: Measurements Of Macrophage Activity and Lymphocyte Proliferamentioning

confidence: 99%

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Enhanced inflammatory and T-helper-1 type responses but suppressed lymphocyte proliferation in patients with seasonal affective disorder and treated by light therapy

Song

Luchtman

Kang

et al. 2015

Journal of Affective Disorders

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“…While in the Lamberti study, the H 1 R agonists 2-(3-trifluoromethylphenyl)histamine and 2thiazolylethylamine showed antidepressant-like activity [Lamberti et al, 1998] and H 1 R binding was shown to be decreased in the frontal and anterior cingulated cortex of depressed patients [Kano et al, 2004], the H 1 R antagonist mepyramine showed antidepressantlike activity in other studies [Delini-Stula et al, 1988;Noguchi et al, 2002]. Similarly, the H 1 R antagonist terfenadine showed antidepressant-like activity in the olfactory bulbectomized model of depression [Song et al, 1996]. The H 2 R antagonist cimetidine showed depression-like activity in vulnerable patients and was suggested to be caused by an imbalance between H 1 R and H 2 R [Billings et al, 1981].…”

Section: Role Of Histamine In Depressionmentioning

confidence: 95%

Histamine receptors as potential therapeutic targets to treat anxiety and depression

Raber

2005

Drug Development Research

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Increasing evidence supports a role for histamine in anxiety and depression. In most studies, histamine and stimulation of the histamine H 1 receptor (H 1 R) or blockade of the histamine H 2 receptor (H 2 R) increase measures of anxiety. In contrast, in most studies histamine reduces depression-like activity, which might be related to effects of histamine on waking. These effects of histamine on anxiety and depression make histamine receptor ligands attractive therapeutic targets. As most studies assessing the potential of histamine receptor ligands on depression did not exclude potential effects of these ligands on locomotor activity, more studies are warranted to determine the exact role of histamine receptor subtypes in depression. The effects of histamine-mediated signaling on anxiety and depression should also be considered in assessments of the potential of histamine H 3 receptor (H 3 R) ligands for conditions characterized by cognitive impairments as well as noncognitive behavioral impairments. Drug Dev. Res. 65:126-132, 2005.

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Behavioural and immunological effects of the antihistamine terfenadine in olfactory bulbectomized rats

Cited by 22 publications

References 29 publications

Effects of histamine H 3 receptor ligands in experimental models of anxiety and depression

Effects of histamine H 3 receptor ligands in experimental models of anxiety and depression

Enhanced inflammatory and T-helper-1 type responses but suppressed lymphocyte proliferation in patients with seasonal affective disorder and treated by light therapy

Histamine receptors as potential therapeutic targets to treat anxiety and depression

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