Behaviour of protein carbonyl groups in juvenile myocardial infarction

Abstract

Acute myocardial infarction (AMI) is accompanied by oxidative stress, and protein oxidation is among the consequences of oxidative stress. We examined the plasma concentration of protein carbonyl groups (PC), a marker of protein oxidation, in a group of young subjects with AMI (45 men and 5 women; mean age 40.4 ± 4.8 yrs). We found a significant increase of PC (p < 0.001) in comparison with normal controls. No difference was observed between patients with AMI characterized by elevated ST segment and those without elevation of ST segment. There was no correlation between the ejection fraction and PC in the whole group nor in the subgroups of STEMI and non-STEMI patients. Subdividing the whole group of AMI patients according to the number of risk factors and the number of stenosed coronary vessels, the difference in PC level was not statistically significant among the subgroups. This study showed an increased protein oxidation in young subjects with recent AMI. Further investigation is needed to ascertain whether this can be a target of therapeutic intervention.

Distinct Patterns of the Autofluorescence of Body Surface: Potential Novel Diagnostic Biomarkers for Stable Coronary Artery Disease and Myocardial Infarction

“…We have further found that the oxidative stress induced by UVC causes the increased epidermal AF by inducing keratin 1 proteolysis (12). Since there are significant increases in oxidative stress in the plasma, serum or urine of SCAD patients (1,2,5,6,20) and MI patients (3,4,9,13,20), it is warranted to determine if there are increases in the epidermal AF of SCAD and MI patients, which may become novel diagnostic biomarkers for the diseases.…”

“…Because there are significant increases in oxidative stress in the plasma, serum or urine of SCAD patients (1,2,5,6,20) and MI patients (3,4,9,13,20), we propose that the increased oxidative stress may induce increases in the epidermal AF of the SCAD and the MI patients by inducing keratin 1 proteolysis. It is warranted to further test the validity of this proposal.…”

Red Cell Distribution Width and Elongation Index in a Cohort of Patients With Juvenile Acute Myocardial Infarction

“…[32][33][34][35][36][37] We must consider that in AMI especially at the initial stage, there are all the doctrinal assumptions that both the erythrocyte deformability and the RDW are involved in the opposite way. In fact, in the initial or acute phase of the AMI, the erythrocyte deformability is adversely affected by increased lipid peroxidation than from that of protein oxidation that some of us have observed and described in this cohort of patients with juvenile myocardial infarction, 7,8 and the trend of RDW could be associated with the cytokine network that seems to accompany the infarct myocardial event. [38][39][40][41][42] The RDW reflects the increase in cytokines such as IL-6 and TNF-alpha.…”

“…As part of the “Sicilian study on juvenile myocardial infarction,” we have reported in recent years about the aspects regarding the hemorheological profile, 1 the metabolic and functional activity of polymorphonuclear leukocytes 2 , 3 and platelets, 4 , 5 the role of genetic polymorphisms, 6 oxidative stress, 7 protein oxidation, 8 the neutrophil/lymphocyte ratio, 9 and plasma viscosity 10 at the initial phase and in the months following the infarct event. However, we have not disregarded neither the behavior of erythrocyte deformability nor the red cell distribution width (RDW), although in part of the entire cohort of these patients, we have previously observed a reduction in erythrocyte deformability, explored with whole blood filtration and diffractometric technique, with respect to the group of healthy volunteers.…”

ST-Elevation Acute Myocardial Infarction in a Young Man

“…On the other hand, in young adults, particularly the NSTEMI group, diabetes mellitus and hypertension remain potent CAD contributors [ 26 ]. In addition, across the whole group, and in both the STEMI and NSTEMI patient subgroups, no correlation was found between LVEF and protein carbonyl [ 42 ]. Both the STEMI and NSTEMI groups had significantly higher plasma-soluble extracellular matrix metalloproteinase inducer levels, compared to both the stable CAD and healthy control groups [ 43 ].…”