Distinct Patterns of the Autofluorescence of Body Surface: Potential Novel Diagnostic Biomarkers for Stable Coronary Artery Disease and Myocardial Infarction

et al. 2018

Preprint

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Our recent studies have suggested that characteristic 'Pattern of Autofluorescence (AF)' of each disease could be a novel biomarker for non-invasive diagnosis of multiple major diseases such as acute ischemic stroke. It is necessary to determine if increased epidermal green AF may be produced by major pathological factors such as inflammation. In our current study, we used C57BL/6Slac mice exposed to LPS to test our hypothesis that inflammation may induce increased epidermal green AF: LPS rapidly induced significant increases in the epidermal green AF of the mice's ears at 1 hr after LPS injection. LPS also dose-dependently increased the epidermal green AF. The AF intensity had a linear relationship with the LPS dosages at both 3 and 7 days after the LPS administration. The AF images exhibited the characteristic structure of the keratinocytes in Stratum Spinosum, suggesting that the origin of the increased AF was keratin 1 and/or keratin 10.Collectively, our current study has provided the first evidence indicating that inflammation can rapidly and dose-dependently induce increased epidermal green AF, suggesting that the green AF may be the first biomarker for non-invasive and rapid detection of systemic inflammation. Since inflammation is a key pathological factor of numerous diseases, our finding has highlighted the value of the epidermal AF as a novel diagnostic biomarker for numerous diseases.

Section: Introductionmentioning

confidence: 99%

Lipopolysaccharide (LPS) induces increased epidermal green autofluorescence of mouse

et al. 2018

Preprint

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“…Our recent studies have suggested that characteristic 'Pattern of Autofluorescence (AF)' could be a novel biomarker for non-invasive diagnosis of AIS (3), MI (25), stable coronary artery disease (25), Parkinson's disease (4) and lung cancer (14). In particular, there are marked and characteristic increases in the green AF intensity in the fingernails and certain regions of the skin of the AIS patients (3) and MI patients (25).…”

Section: Introductionmentioning

confidence: 99%

Green autofluorescence intensity of skin and fingernails: A novel biomarker for non-invasive evaluation of pathological state of blood vessels

Zhang

et al. 2018

Preprint

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Stroke and myocardial infarction (MI) are two leading causes of death around the world. It is of great significance to establish novel and non-invasive approaches for evaluating pathological state of blood vessels, so that early interventions may be carried out to prevent incidence of stroke or MI. Our recent studies have suggested that altered 'Pattern of Autofluorescence (AF)' of skin and fingernails are novel biomarkers of acute ischemic stroke (AIS) and MI. In particular, our studies have shown characteristic increases in the green AF intensity of the fingernails and certain regions of the skin of AIS patients and MI patients. By determining the skin's green AF of the Healthy Group, the Low-Risk Group for Developing AIS, and the High-Risk Group for Developing AIS, our current study has indicated that the green AF intensity in the right and left Ventroforefingers and Dorsal Antebrachium, the right Dorsal Centremetacarpus, Dorsal Index Fingers and Centremetacarpus, as well as the left Index Fingernails and Ventriantebrachium, is highly correlated with the risk of developing AIS. Our study has also suggested that oxidative stress and inflammation may account for the increased AF intensity in the Low-Risk Group and the High-Risk Group.These findings have suggested that the green AF intensity of the fingernails and certain regions of the skin is a novel biomarker for non-invasive evaluation of the injury levels of blood vessels and the risk of developing AIS or MI.

“…Human autofluorescence (AF) has been used for non-invasive diagnosis of such diseases as diabetes (3,8). Our recent studies have suggested that characteristic 'Pattern of Epidermal Green Autofluorescence (AF)' of each disease may be novel biomarkers for non-invasive diagnosis of a number of diseases, including acute ischemic stroke (AIS) (1), myocardial infarction (MI) (14), stable coronary artery disease (14), Parkinson's disease (2) and lung cancer (7). Our study has also shown that the AF intensity in certain regions of skin is highly correlated with a person's risk to develop AIS, suggesting that the AF may also become a biomarker for evaluation of injury levels of vascular system (6).…”

Section: Introductionmentioning

confidence: 99%

Professional Swimmers and Normal Populations have Different Patterns of Epidermal Green Autofluorescence

et al. 2019

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Our recent studies have suggested that green autofluorescence of the fingernails and certain regions of skin may be novel biomarkers for disease diagnosis and evaluation of the injury state of cardiovascular system. Our study has also suggested that oxidative stress may produce the increased epidermal green AF by altering keratin 1. Since athletes' body may have increased oxidative stress and inflammation, we proposed our hypothesis that athletes may have increased green AF in their fingernails and certain regions of their skin. In current study we tested this hypothesis by determining the green AF of professional swimmers. We found that compared with age-matched controls, both the green AF intensity and AF asymmetry in both right and left antebrachium and Ventriantebrachium of the professional swimmers is significantly higher. In left Dorsal Centremetacarpus, the green AF intensity of the professional swimmers is significantly higher than that of the age-matched controls. In contrast, the green AF intensity or AF asymmetry of the professional swimmers is not significantly different from that of the age-matched controls in Centremetacarpus, Ventroforefinger, Dorsal Index Finger and Index Fingernails. Collectively, our study has provided first evidence suggesting that athletes have increased green AF intensity and asymmetry in certain regions of their skin. Based on this finding, we may evaluate non-invasively the levels of oxidative damage and inflammation in athletes' body.