Behaviour of Arterial Pressure in Different Stages of Polycystic Kidney Disease

Abstract

Arterial pressure was measured in 94 adult patients with polycystic kidney disease (PKD) and the data obtained were compared with those of two groups of patients with other chronic renal diseases. Patients with PKD having a glomerular filtration rate within normal limits were more frequently hypertensive than those with other renal diseases. This relationship was reversed when patients with severe renal insufficiency were considered.

The Impact of Ciclosporin in Patients with Adult Polycystic Kidney Disease Following Transplantation

“…Blood CSA levels in the present study were in the low therapeutic range (table 4) and are thus unlikely to be the causative factor in the etiopathogenesis of the observed hypertension. Furthermore, post transplant hypertension was also observed in the AZA cohort suggesting that the underlying renal disease with its known propensity to hypertension [27], even when renal function is relatively normal, may be playing a role.…”

Autosomal dominant polycystic kidney disease and the heart and brain

“…Hypertension is the most frequent initial presentation of ADPKD, occurring in 50% to 75% of cases and usually preceding the onset of renal failure. 2,22 Hypertension is more common in male ADPKD patients, begins early in the course of the disease, and is diagnosed around the fourth decade of life. 21 In a study in 2007, de Almeida et al 23 used 24-hour ambulatory blood pressure monitoring early in the course of ADPKD and found significantly higher systolic, diastolic, and mean 24-hour blood pressures in ADPKD patients who had normal in-office blood pressure than in normotensive controls.…”

“…31 Moreover, another study found that the prevalence of hypertension is higher in ADPKD patients than in those with other nephropathies with preserved renal function, but this association reverses with significant decline in kidney function. 22 Hypertension occurs in 50%-75% of patients with ADPKD Early diagnosis of hypertension and effective control of it, even before ADPKD is diagnosed, is crucial to reduce cardiovascular mortality. Aggressive blood pressure control in the prehypertensive phase of ADPKD will also help reduce the incidence of left ventricular hypertrophy and mitral regurgitation and slow the progression of renal failure (Figure 2).…”

Review: Autosomal Dominant Polycystic Kidney Disease: Role of the Renin-Angiotensin System in Raised Blood Pressure in Progression of Renal and Cardiovascular Disease

“…Once on dialysis nearly all affected individuals are hypertensive. [9][10][11][12][13] Hypertension used to be thought to be a significant factor in the progression of renal failure in ADPKD, 14 and it is the major risk factor for the premature cardiovascular disease that occurs, particularly in younger patients, and which in turn is the most frequent cause of mortality in ADPKD patients. 15 It is well recognised that deterioration of renal excretory function in ADPKD follows a unique time course in that glomerular filtration rate remains constant for many years and only declines relatively late in the course of the disease, when mechanical compression of normal renal tissue by cysts occurs.…”