Behaviour of a Peru strain of Trypanosoma cruzi in Rhesus monkeys

Marsden, Philip D.; Voller, A.; Seah, S.; Hawkey, Carol A.; Green, D.

doi:10.1590/s0037-86821970000300004

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…[2][3][4][5][6][7][8][9][10] The acute phase of T. cruzi infection in rhesus monkeys is similar to that which occurs in humans. [11][12][13] Our previous studies described the acute and early chronic phases of infection in these monkeys over a three-year period of experimental infection with the Colombian strain of T. cruzi. Chagoma, patent parasitemia, circulating IgM and IgG antibodies specific for T. cruzi, and hematologic alterations (leukocytosis and lymphocytosis) were observed in the acute phase.…”

Section: Introductionmentioning

confidence: 99%

Chronic Chagas’ Disease in Rhesus Monkeys (Macaca Mulatta): Evaluation of Parasitemia, Serology, Electrocardiography, Echocardiography, and Radiology

Carvalho¹,

Andrade²,

Xavier³

et al. 2003

Am J Trop Med Hyg

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Severe chronic damage to the heart and gastrointestinal tract in patients with Chagas' disease are often observed 10-20 years after the acute phase. The course of long-lasting infection with the Colombian strain of Trypanosoma cruzi was studied in seven rhesus monkeys infected for 15-19 years. Subpatent parasitemia was detected in all studied animals, using hemoculture (two of seven), artificial xenodiagnosis (three of seven), and a polymerase chain reaction PCR (six of six). High titers of specific IgG antibody to T. cruzi persisted throughout the chronic phase of infection. Abnormal electrocardiographic (three of six) and echocardiographic (one of six) patterns detected in the T. cruzi-infected monkeys were possibly related to parasite-triggered myocardial damage. The results suggest that rhesus monkeys experimentally infected with T. cruzi, besides reproducing the acute phase of Chagas' disease, also develop chronic chagasic cardiomyopathy.

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Section: Introductionmentioning

confidence: 99%

Chronic Chagas’ Disease in Rhesus Monkeys (Macaca Mulatta): Evaluation of Parasitemia, Serology, Electrocardiography, Echocardiography, and Radiology

Carvalho¹,

Andrade²,

Xavier³

et al. 2003

Am J Trop Med Hyg

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“…cruzi strains from the following countries may be mentioned. Argentina, Belize (British Hondu ras), Chile, Colombia, Costa Rica, México, Peru, Venezuela and the U.S.A. (3,4,17,18,19,20,21,25,26,27,30,31,33,34).…”

Section: Introductionmentioning

confidence: 99%