Behaviorally-Evoked Cardiovascular Reactivity and Hypertension: Conceptual Issues and Potential Associations

Manuck, Stephen B.; Kasprowicz, Alfred L.; Muldoon, Matthew F.

doi:10.1207/s15324796abm1201_2

Cited by 275 publications

(150 citation statements)

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“…37 Although ABP monitoring has been used as a means of assessing the generalizability of laboratory-based BP cardiovascular reactivity to actual real life situations, 38–40 this is the first study to assess whether the sources of individual difference in BP regulation under standardized laboratory conditions are different from BP regulation in real life settings. We observed that only 39% of the heritability of 24-h SBP and 42% of 24-h DBP were attributed to genes that also influence stress BP.…”

Section: Discussionmentioning

confidence: 99%

Genetic influence on blood pressure measured in the office, under laboratory stress and during real life

Wang

Ding

et al. 2010

Hypertens Res

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To determine to what extent the genetic influences on blood pressure (BP) measured in the office, under psychologically stressful conditions in the laboratory and during real life are different from each other. Office BP, BP during a video game challenge and a social stressor interview, and 24-h ambulatory BP were measured in 238 European American and 186 African American twins. BP values across the two tasks were averaged to represent stress levels. Genetic model fitting showed no ethnic or gender differences for any of the measures. The model fitting resulted in heritability estimates of 63, 75 and 71% for office, stress and 24-h systolic BP (SBP) and 59, 67 and 69% for diastolic BP (DBP), respectively. Up to 81% of the heritability of office SBP and 71% of office DBP were attributed to genes that also influenced stress BP. However, only 45% of the heritability of 24-h SBP and 49% of 24-h DBP were attributed to genes that also influence office BP. Similarly, about 39% of the heritability of 24-h SBP and 42% of 24-h DBP were attributed to genes that also influence stress BP. Substantial overlap exists between genes that influence BP measured in the office, under laboratory stress and during real life. However, significant genetic components specific to each BP measurement also exist. These findings suggest that partly different genes or sets of genes contribute to BP regulation in different conditions.

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Section: Discussionmentioning

confidence: 99%

Genetic influence on blood pressure measured in the office, under laboratory stress and during real life

Wang

Ding

et al. 2010

Hypertens Res

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“…Both TBT and SBH therefore imply that communicative behaviors aimed at building and maintaining significant, intimate, and supportive social relationshipssuch as the communication of affection -should be inversely associated with susceptibility to stress. This is efficacious to health not only in its own right, but also in light of evidence that exaggerated cardiovascular and hormonal responses to stressors are associated with elevated risk of cardiovascular disease (Lynch, Everson, Kaplan, Salonen, & Salonen, 1998), as well as hypertension and associated organ damage (Manuck, Kasprowicz, & Muldoon, 1990). …”

Section: Affectionate Communication and Stressmentioning

confidence: 99%

Affectionate Communication Received from Spouses Predicts Stress Hormone Levels in Healthy Adults

Floyd¹,

Riforgiate

2008

Communication Monographs

114

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“…Phasic blood pressure hyperactivity has been discussed as an important risk factor associated with hypertensive development (Pickering and Gerin, 1990;Manuck et al, 1990;Turner, 1994). Thus, subjects showing the response specificity of blood pressure hyperactivity may be at risk for developing hypertension at a later point in time.…”

Section: Significance Of the Baroreceptor -Brain Circuitry For A Modementioning

confidence: 99%

Psychophysiology of arterial baroreceptors and the etiology of hypertension

Rau

Elbert

2001

Biological Psychology

159

143

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Arterial baroreceptors are sensitive to blood pressure dependent blood vessel dilation. They play a key role in the short term regulation of blood pressure. Their impact on psychological and psychophysiological aspects is of increasing interest. The review focuses on experimental techniques for the controlled baroreceptor manipulation. Results from the application of these techniques show that baroreceptor activation influences the cardiovascular system as well as central nervous functioning: Behavioral and electrophysiological measures of arousal, low level reflexes and pain responses are modulated through baroreceptor manipulation. The observation of an overall dampening ('barbiturate like') effect of baroreceptor activity led Dworkin et al. formulate the theory of learned hypertension: Subjects might experience blood pressure dependent baroreceptor activation as stress and pain relieving. High blood pressure periods become negatively reinforced. Phasic high blood pressure might develop as a coping strategy. Data from a longitudinal human study supporting this theory are reported.

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Behaviorally-Evoked Cardiovascular Reactivity and Hypertension: Conceptual Issues and Potential Associations

Cited by 275 publications

References 0 publications

Genetic influence on blood pressure measured in the office, under laboratory stress and during real life

Genetic influence on blood pressure measured in the office, under laboratory stress and during real life

Affectionate Communication Received from Spouses Predicts Stress Hormone Levels in Healthy Adults

Psychophysiology of arterial baroreceptors and the etiology of hypertension

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