Behavioral study on the interactions between trazodone and L-dopa

Baldini, A; Ciottoli, G B

doi:10.1016/s0031-6989(79)80088-0

Cited by 8 publications

(3 citation statements)

References 7 publications

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“…Trazodone hydrochloride (TRA) was mainly developed as a selective serotonin reuptake inhibitor and is widely used in the treatment of depression, 1 , 2 but there is no consensus on the polysomnographic effects of this drug. It is reported to cause an increase in slow wave sleep (combined stages 3 and 4, SWS), 3 –7 but rapid eye movement (REM) latency is variously reported to be prolonged, 3 , 6 , 8 while REM sleep is suggested to be reduced 7 , 8 or unchanged 3 –6…”

Section: Introductionmentioning

confidence: 99%

Effects of trazodone hydrochloride and imipramine on polysomnography in healthy subjects

Yamadera

Nakamura

Suzuki

et al. 1998

Psychiatry Clin Neurosci

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Key wordsPolysomnography was performed on eight healthy men with trazodone hydrochloride, imipramine and placebo. Trazodone hydrochloride increased slow wave sleep significantly. Imipramine prolonged rapid eye movement (REM) latency and decreased the percentage of REM sleep significantly. Trazodone decreased stages 1 and 2 sleep, while imipramine increased it. These findings suggest that the antidepressive effect of trazodone might be different from that of imipramine with the suppression of REM sleep. healthy men, imipramine, polysomnography, REM, slow wave sleep, trazodone hydrochloride.

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Section: Introductionmentioning

confidence: 99%

Effects of trazodone hydrochloride and imipramine on polysomnography in healthy subjects

Yamadera

Nakamura

Suzuki

et al. 1998

Psychiatry Clin Neurosci

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“…Trazodone differs from neuroleptic agents in that it lacks cataleptogenic properties, does not inhibit the effects of apomorphine and levodopa in rats, and has only weak hypothermic 34,36 Trazodone decreases spontaneous motor activity (in high doses) and interacts with known CNS depressants such as barbiturates and alcohol. In mice oral trazodone increased the hexobarbital sleeping time.3 It lacks (even at high doses) anticonvulsant activity and has only weak muscle relaxant effect^.^^^^^ Trazodone did not produce any stimulant activity in laboratory test animakZ2…”

Section: Behavioral Effectsmentioning

confidence: 99%

Trazodone Hydrochloride: A Wide Spectrum Antidepressant with a Unique Pharmacological Profile

et al. 1982

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Trazodone is a new antidepressant agent that was recently introduced in the United States. It has a unique pharmacological profile that is not typical of either tricyclic or monoamine oxidase inhibitor antidepressants. As such it represents a new class of antidepressant drugs. The efficacy of trazodone has been clearly established in comparative studies with imipramine and amitriptyline. Major depression is the principal indication for its use, but good results have been shown in a wide variety of depressive subtypes. Of particular importance is the low frequency of adverse reactions seen with this drug.

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“…Trazodone was mainly developed as a serotonergic drug and is widely used in the treatment of depression 1 , 2 . It is widely reported to cause an increase in slow wave sleep (combined stages 3 and 4, slow wave sleep (SWS) 3 –8 .…”

Section: Introductionmentioning

confidence: 99%

Effects of trazodone on polysomnography, blood concentration and core body temperature in healthy volunteers

Yamadera

Suzuki

Nakamura

et al. 1999

Psychiatry Clin Neurosci

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Polysomnography, blood concentration and core body temperature recordings were performed on 12 healthy volunteers with administration of trazodone and placebo. Trazodone increased slow wave sleep (SWS), and decreased the average, the highest and lowest core body temperature significantly compared to placebo. The blood concentration of trazodone correlated positively with amplitude (the difference between the highest and lowest temperature) and %SWS during the first period of a sleep phase divided into three periods, and negatively with the lowest temperature. The appearance time of the lowest temperature correlated negatively with %SWS.

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Behavioral study on the interactions between trazodone and L-dopa

Cited by 8 publications

References 7 publications

Effects of trazodone hydrochloride and imipramine on polysomnography in healthy subjects

Effects of trazodone hydrochloride and imipramine on polysomnography in healthy subjects

Trazodone Hydrochloride: A Wide Spectrum Antidepressant with a Unique Pharmacological Profile

Effects of trazodone on polysomnography, blood concentration and core body temperature in healthy volunteers

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