Trazodone Hydrochloride: A Wide Spectrum Antidepressant with a Unique Pharmacological Profile

Γεωργοτασ, Αναστασιοσ; Forsell, Thomas L; Mann, J. John; Kim, Mary; Gershon, Samuel

doi:10.1002/j.1875-9114.1982.tb03193.x

Cited by 57 publications

(5 citation statements)

References 66 publications

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“…Trazodone is an antidepressant agent with a chemical structure unrelated to existing psychomotor drugs (Al-Yassiri et al, 1981;Brogden et al, 1981;Ayd & Settle, 1982;Georgotas et al, 1982;Rawls, 1982) which is sedative and impairs critical flicker fusion threshold in young and elderly volunteers (Bayer et al, 1983).…”

Section: Introductionmentioning

confidence: 99%

An evaluation of possible interactions between ethanol and trazodone or amitriptyline.

Warrington¹,

Ankier²,

Turner³

1984

Brit J Clinical Pharma

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The pharmacodynamic effects of single doses of trazodone (100 mg), amitriptyline (50 mg) or placebo either alone or with ethanol (0.5 ml/kg) were investigated in six healthy volunteers in a double‐blind crossover study. Plasma concentrations of the drugs and ethanol were also measured. Pharmacodynamic tests were critical flicker fusion frequency threshold (CFF), choice reaction time (CRT), manual dexterity, a digit span test and visual analogue scales. Blood ethanol concentrations were not influenced by the co‐administration of either antidepressant. tmax for trazodone was prolonged by ethanol but the other pharmacokinetic parameters for trazodone and amitriptyline were not influenced by ethanol. Trazodone and amitriptyline caused the expected profound depressant effects on CFF, CRT, manual dexterity and on the rating scales for drowsiness, ‘clear‐headedness’, aggression and disinhibition. Ethanol alone impaired manual dexterity, increased drowsiness, reduced ‘clear headedness’ and also tended to reduce feelings of aggression. In combination with either trazodone or amitriptyline, ethanol caused little additional effect except in the case of manual dexterity which was further impaired. This result may reflect the profound effects of the antidepressants alone and does not suggest that it is safe for patients receiving antidepressant medication to take ethanolic drinks.

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Section: Introductionmentioning

confidence: 99%

An evaluation of possible interactions between ethanol and trazodone or amitriptyline.

Warrington¹,

Ankier²,

Turner³

1984

Brit J Clinical Pharma

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show abstract

“…From these and other data [24], trazo done seems to produce fewer anticholinergic side effects than the tricyclic antidepressant agents, although this is usually only statisti cally significant for the complaint of dry mouth. Drowsiness does occur with trazo done, but not to the extent of producing an appreciable dropout rate, as compared to that seen with mianserin.…”

Section: Few Anticholinergic Effectsmentioning

confidence: 99%

Recent Experience with Trazodone

Lader¹

1987

Psychopathology

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Trazodone is an atypical antidepressant with additional anxiolytic effects. Recent European experience with trazodone is reviewed with respect to antidepressant efficacy, side effects (particularly anticholinergic), anxiolytic actions, cardiotoxicity, overdosage, and use in the elderly. From the data presented in this paper it is concluded that trazodone is effective both as an antidepressant and as an anxiolytic agent, with few side effects and low cardiotoxicity. It is safer than tricyclic antidepressant agents in overdosage and better tolerated in the elderly patient.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Trazodone is an antidepressant agent with a chemical structure unrelated to existing psychoactive drugs [AlYassiri et al, 1981;Brogden et al, 1981;Ayd and Settle, 1982;Georgotas et al, 1982;Rawls, 1982] which is sed ative and impairs critical flicker fusion threshold in young and elderly volunteers [Bayer et al, 1983], The present study was designed to examine the phar macodynamic effect and pharmacokinetics of trazodone in comparison to a standard sedative antidepressant, amitriptyline [Hindmarch, 1980], alone or in combina tion with a 'social dose' of ethanol to assess possible interactions between the agents.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Possible Interactions between Ethanol and Trazodone or Amitriptyline

Warrington¹,

Ankier²,

Turner³

1986

Neuropsychobiology

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The pharmacodynamic effects of single doses of trazodone (100 mg), amitriptyline (50 mg) or placebo either alone or with ethanol (0.5 ml/kg) were investigated in 6 healthy volunteers in a double-blind crossover study. Plasma concentrations of the drugs and ethanol were also measured. Pharmacodynamic tests were critical flicker fusion frequency threshold (CFF), choice reaction time (CRT), manual dexterity, a digit span test and visual analogue scales. Blood ethanol concentrations were not influenced by the co-administration of either antidepressant. t_max for trazodone was prolonged by ethanol but the other pharmacokinetic parameters for trazodone and amitriptyline were not influenced by ethanol. Trazodone and amitriptyline caused the expected profound depressant effects on CFF, CRT, manual dexterity and on the rating scales for drowsiness, ‘clearheadedness’, aggression and disinhibition. Ethanol alone impaired manual dexterity, increased drowsiness, reduced ‘clearheadedness’ and also tended to reduce feelings of aggression. In combination with either trazodone or amitriptyline, ethanol caused little additional effect except in the case of manual dexterity, which was further impaired. This result may reflect the profound effects of the antidepressants alone and does not suggest that it is safe for patients receiving antidepressant medication to take ethanolic drinks.

show abstract

Trazodone Hydrochloride: A Wide Spectrum Antidepressant with a Unique Pharmacological Profile

Cited by 57 publications

References 66 publications

An evaluation of possible interactions between ethanol and trazodone or amitriptyline.

An evaluation of possible interactions between ethanol and trazodone or amitriptyline.

Recent Experience with Trazodone

Evaluation of Possible Interactions between Ethanol and Trazodone or Amitriptyline

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