Behavioral, Situational, and Temporal Effects of Treatment of ADHD With Methylphenidate

Schachar, Russell; Tannock, Rosemary; Cunningham, Charles; Corkum, Penny

doi:10.1097/00004583-199706000-00011

Cited by 195 publications

(137 citation statements)

References 25 publications

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“…65,86 In these studies, the non-drug interventions were parent training or support, and parent and teacher education, respectively. For both studies, the results were generally significant C, crossover trial (number of crossovers); C-GAS, Children's Global Assessment Scale; CGI, Clinical Global Impression; CPRS, Conners' Parent Rating Scale; CTRS, Conners' Teacher Rating Scale; IOWA-C, IOWA Conners' Rating Scale; P, parallel trial; SSERS, Stimulant Drug Side Effects Rating Scale; TIP, Telephone Interview Probe.…”

Section: Discussionmentioning

confidence: 99%

“…Three of the studies reported results on hyperactivity, 51,65,86 but one of them presented data in graphs only and was not included in Table 27. 51 The remaining two studies both assessed hyperactivity using Conners' scales and also other measures.…”

Section: Hyperactivitymentioning

confidence: 99%

“…51 The remaining two studies both assessed hyperactivity using Conners' scales and also other measures. In Schachar and colleagues' study, 86 the non-drug intervention was parent training or support, and in the Klein and Abikoff 65 study, the non-drug intervention involved parent and teacher education. These parallel studies both reported significant differences in favour of MPH plus non-drug intervention compared with non-drug intervention when assessed by teachers, but not when assessed by parents.…”

Section: Hyperactivitymentioning

confidence: 99%

“…Generally, combined treatment was superior to non-drug treatment for hyperactivity 42,53,71 and Clinical Global Impression. 51,65 In two studies, hyperactivity was improved when assessed by teachers, but not by parents 65,86 (in these cases the non-drug interventions were parent training or support and parent and teacher education).…”

Section: [Confidential Information From One Study That Reported On Cgmentioning

confidence: 99%

See 3 more Smart Citations

A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents

King

Griffin²,

Hodges³

et al. 2006

Health Technol Assess

143

117

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTA NHS R&D HTA ProgrammeT he research findings from the NHS R&D Health Technology Assessment (HTA) Programme directly influence key decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC) who rely on HTA outputs to help raise standards of care. HTA findings also help to improve the quality of the service in the NHS indirectly in that they form a key component of the 'National Knowledge Service' that is being developed to improve the evidence of clinical practice throughout the NHS.The HTA Programme was set up in 1993. Its role is to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined to include all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care, rather than settings of care.The HTA Programme commissions research only on topics where it has identified key gaps in the evidence needed by the NHS. Suggestions for topics are actively sought from people working in the NHS,...

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Section: Discussionmentioning

confidence: 99%

Section: Hyperactivitymentioning

confidence: 99%

Section: Hyperactivitymentioning

confidence: 99%

Section: [Confidential Information From One Study That Reported On Cgmentioning

confidence: 99%

See 2 more Smart Citations

A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents

King

Griffin²,

Hodges³

et al. 2006

Health Technol Assess

143

117

View full text Add to dashboard Cite

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“…Tedavi kararı verilirken belirtilerin akut tedavisinin, ilaç tedavisinin olası uzun dönem yan etkileriyle özenli bir şekilde değerlendirilmesi gereklidir. [1][2][3][4] İstatistiksel veriler, çocuklarda stimü-lan ve antidepresan ilaçların artan oranda ve daha erken yaşlarda kullanılmaya başlandığına ve pediatrik farmakoterapi yaygınlığının arttığına işaret etmektedir. [5][6][7][8] Mevcut depresyonun tedavi edilmesinin, gelecekte daha ciddi depresif epizodlardan koruma sağladığı bildirilmiştir.…”

unclassified

Effects of Psychostimulant Drugs on Developing Brain

Durukan¹,

Erdem²,

Kara³

et al. 2013

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖZETPsikostimülanlar dikkat eksikliği hiperaktivite bozukluğu tedavisinde yaklaşık 70 yıldır kullanılmasına rağmen, bu ilaçların gelişen beyin üzerindeki uzun dönem etkileri hakkında çok az şey bilinmektedir. Psikostimülanların saptanan etkileri maruziyetin zamanı, yapılan değerlendirmenin zamanı ve cinsiyetten etkilenmektedir. Preklinik çalışmalar, ergenlik öncesinde kronik stimülan maruziyetinin ters duyarlılaşma veya tolerans oluşmasına yol açtığı ve bunun da ergenlik ve sonrasında stimulanların etkinliğinde azalmaya yol açacağına işaret etmektedir. Preklinik çalışmalar psikostimülanların uzun dönem etkileri olabileceğine işaret etmektedir. Ancak bu olası etkilerin klinik olarak hangi düzeyde olabileceğinin araştırılması gerekmektedir. Psikostimülan ilaçların beyin üzerindeki etkilerini daha iyi anlamak için farklı yaş gruplarında yapıla-cak çalışmalara gereksinim olduğu düşünülmektedir.. Anahtar Sözcükler: Psikostimülan, gelişen beyin, dikkat eksikliği hiperaktivite bozukluğu. ABSTRACTAlthough psychostimulants have been used for the treatment of attention deficit hyperactivity disorder for approximately 70 years, little is known about the long term effects of these drugs on developing brain. The observable effects of psychostimulants are influenced by the timing of exposure, the age of examination after drug exposure and sex. Preclinical studies point out that chronic psychostimulant exposure before adolescence cause reverse sensitization or tolerance and this leads to reduction in stimulant effectiveness in adolesecence and adulthood. Preclinical studies show the potential long term effects of psychostimulants. But it is necessary to investigate the relationship between preclinical effects and clinical practice. A developmental approach is needed to understand the impact of pediatric medications on the brain that ©2013, Psikiyatride Güncel Yaklaşımlar eISSN:1309-0674 pISSN:1309-0658

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A 14-Month Randomized Clinical Trial of Treatment Strategies for Attention-Deficit/Hyperactivity Disorder

1999

Arch Gen Psychiatry

2,884

184

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Background: Previous studies have demonstrated the short-term efficacy of pharmacotherapy and behavior therapyforattention-deficit/hyperactivitydisorder(ADHD), but no longer-term (ie, Ͼ4 months) investigations have compared these 2 treatments or their combination.Methods: A group of 579 children with ADHD Combined Type, aged 7 to 9.9 years, were assigned to 14 months of medication management (titration followed by monthly visits); intensive behavioral treatment (parent, school, and child components, with therapist involvement gradually reduced over time); the two combined; or standard community care (treatments by community providers). Outcomes were assessed in multiple domains before and during treatment and at treatment end point (with the combined treatment and medication management groups continuing medication at all assessment points). Data were analyzed through intentto-treat random-effects regression procedures.Results: All 4 groups showed sizable reductions in symptoms over time, with significant differences among them in degrees of change. For most ADHD symptoms, children in the combined treatment and medication man-

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Behavioral, Situational, and Temporal Effects of Treatment of ADHD With Methylphenidate

Cited by 195 publications

References 25 publications

A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents

A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents

Effects of Psychostimulant Drugs on Developing Brain

A 14-Month Randomized Clinical Trial of Treatment Strategies for Attention-Deficit/Hyperactivity Disorder

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