Behavioral responses to physical vs. social novelty in male and female laboratory rats

Cavigelli, Sonia A.; Michael, Kerry C.; West, Sheila G.; Klein, Laura Cousino

doi:10.1016/j.beproc.2011.06.006

Cited by 24 publications

(16 citation statements)

References 31 publications

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“…In the social approach test, rats showed a clear preference to be near an unfamiliar rat confined behind wire mesh than near a novel object, consistent with a previous report that rats prefer novel social stimuli over novel physical stimuli (Cavigelli, Michael, West, & Klein, ). In the social interaction test arena, however, rats spent more time investigating the novel object in the 10 min interval than they did in the next 10 min with a stimulus rat.…”

Section: Discussionsupporting

confidence: 88%

Social instability stress in adolescence increases anxiety and reduces social interactions in adulthood in male long–evans rats

Green

Barnes

McCormick

2012

Developmental Psychobiology

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We investigated the effects of social instability stress (daily 1-hr isolation, change of cage partner, postnatal day 30-45) in adolescence in male rats on open field exploration and social behavior in adulthood. Social stressed rats had longer latencies to enter the center of an open field and then took longer to approach an object placed in the center of the field. When another rat was placed in the open field, stressed rats spent less time in social interaction than control rats, particularly when paired with another stressed, rather than a control, rat. The groups did not differ in social approach tests (when a stimulus rat was separated by wire mesh) nor in novel object exploration (when controlling for open field anxiety). The results suggest social stress in adolescence increases open field anxiety while maintaining exploratory behavior, and alters social interactions in adulthood.

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Section: Discussionsupporting

confidence: 88%

Social instability stress in adolescence increases anxiety and reduces social interactions in adulthood in male long–evans rats

Green

Barnes

McCormick

2012

Developmental Psychobiology

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“…Interestingly, optogenetic stimulation enhanced the object exploration in the animals in a dose-dependent manner during the 20-min monitoring period (34.5 ± 5.8 s for 10-Hz group and 85.8 ± 33.0 s for 20-Hz group compared with 14.8 ± 3.3 s for the nonstimulation group, *P ≤ 0.05, one-way ANOVA, Dunn's method). In contrast, open-field exploration activity was not significantly different between the stimulation and nonstimulation groups [F (2,19) = 0.483, P = 0.624, two-way rmANOVA] (Fig. 4B).…”

Section: Optogenetic Modulation Of Septo-hippocampal Gabaergic Fibersmentioning

confidence: 99%

“…Social exploration involves complex processes that differ from those involved in the nonsocial exploration (2). Several distinctions were proposed to categorize the different forms of nonsocial exploratory behaviors from a motivational perspective (3).…”

Section: Ca V 31 T-type Ca2mentioning

confidence: 99%

Medial septal GABAergic projection neurons promote object exploration behavior and type 2 theta rhythm

Gangadharan

Shin

Kim

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Exploratory drive is one of the most fundamental emotions, of all organisms, that are evoked by novelty stimulation. Exploratory behavior plays a fundamental role in motivation, learning, and well-being of organisms. Diverse exploratory behaviors have been described, although their heterogeneity is not certain because of the lack of solid experimental evidence for their distinction. Here we present results demonstrating that different neural mechanisms underlie different exploratory behaviors. Localized Ca v 3.1 knockdown in the medial septum (MS) selectively enhanced object exploration, whereas the null mutant (KO) mice showed enhancedobject exploration as well as open-field exploration. In MS knockdown mice, only type 2 hippocampal theta rhythm was enhanced, whereas both type 1 and type 2 theta rhythm were enhanced in KO mice. This selective effect was accompanied by markedly increased excitability of septo-hippocampal GABAergic projection neurons in the MS lacking T-type Ca 2+ channels. Furthermore, optogenetic activation of the septo-hippocampal GABAergic pathway in WT mice also selectively enhanced object exploration behavior and type 2 theta rhythm, whereas inhibition of the same pathway decreased the behavior and the rhythm. These findings define object exploration distinguished from open-field exploration and reveal a critical role of T-type Ca 2+ channels in the medial septal GABAergic projection neurons in this behavior. Ca v 3.1 T-type Ca2+ channel | exploratory behaviors | hippocampal theta rhythm | medial septum | septo-hippocampal GABAergic neurons

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“…A gender difference also emerged for young rats: males had an increase in dendrite length, but females did not (Kolb et al, 2003). Others have also found sex differences in responses to enriched environments, which might be related to differences in male and female rat spatial learning and exploratory behavior (Cavigelli, Michael, West, & Klein, 2011). …”

Section: Neuroplasticity After the Juvenile Periodmentioning

confidence: 99%

Old dogs learning new tricks: Neuroplasticity beyond the juvenile period

Lillard

Erişir

2011

Developmental Review

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Twenty years ago, the prevalent view in psychology was that although learning and the formation of new memories are lifelong occurrences, the neural changes associated with these events were all in the existing receptors. No new neural hardware, from synapses to neurons, was thought to appear after a protracted period early in life. In the past 20 years, another view has supplanted this one, showing that although the juvenile period is especially suited to neuroplastic adaptation, there is hard neuroplastic change later in life as well. We review a selection of evidence for this view from both animal and human models, showing how it reflects three principles of neuroplasticity: 1) earlier and later experience-induced changes to neuroarchitecture differ in degree more so than in type; 2) the types of experiences that lead to neuroplastic change narrow with age; and 3) differences in the amenability of neural circuitry to change result from basic differences in neuroarchitecture and neuroenvironment in different phases of development.

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Behavioral responses to physical vs. social novelty in male and female laboratory rats

Cited by 24 publications

References 31 publications

Social instability stress in adolescence increases anxiety and reduces social interactions in adulthood in male long–evans rats

Social instability stress in adolescence increases anxiety and reduces social interactions in adulthood in male long–evans rats

Medial septal GABAergic projection neurons promote object exploration behavior and type 2 theta rhythm

Old dogs learning new tricks: Neuroplasticity beyond the juvenile period

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