Behavioral patterns proceeding from liver thermoreceptors

Bella, L. Di; Tarozzi, G; Rossi, Michela; Scalera, Giuseppe

doi:10.1016/0031-9384(81)90078-0

Cited by 6 publications

(5 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During heating sessions, the liver temperature always remained within the physiological range (Adachi et al. , 1991; Di Bella et al. , 1981; Toutain et al.…”

Section: Discussionmentioning

confidence: 99%

“…We chose 39.5°C as the first level of heating because the ratÕs normal body temperature is close to 39.3°C when nocturnal meals terminate (Amici et al, 1998). The liver was never heated above 40.5°C, in order to remain within the physiological range (Adachi et al, 1991;Di Bella et al, 1981;Toutain et al, 1977;Valatx et al, 1973).…”

Section: Liver Heatingmentioning

confidence: 99%

“…At the end of the experiments, post-mortem examination confirmed that the sensor probes were still in the right positions and that the size, colour and texture of the liver and the peritoneal serous membrane were normal. During heating sessions, the liver temperature always remained within the physiological range (Adachi et al, 1991;Di Bella et al, 1981;Toutain et al, 1977;Valatx et al, 1973), in order to avoid tissue damage and impairment of the liver function. We can also rule out a possible effect of tactile stimulation by the probes, as each rat served as its own control.…”

Section: Study Limitationsmentioning

confidence: 99%

“…Many studies have shown that the liver temperature influences food intake and metabolism (De Vries et al. , 1993; Di Bella et al. , 1981; Himms‐Hagen, 1995).…”

Section: Introductionmentioning

confidence: 99%

“…In view of the liverÕs central role in intermediary metabolism, one could hypothesize that the organ selectively controls energy-conserving processes. Many studies have shown that the liver temperature influences food intake and metabolism (De Vries et al, 1993;Di Bella et al, 1981;Himms-Hagen, 1995). Changes in the liverÕs thermal status restrict the calorie intake and induce a hypometabolic state.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Sleep structure and feeding pattern changes induced by the liver’s thermal status in the rat

Hajjaji

Pelletier

Delanaud

et al. 2011

Journal of Sleep Research

View full text Add to dashboard Cite

Summary Given the liver’s importance in controlling metabolic homeostasis in mammals, we sought to establish (i) whether the thermal status of this organ was involved in the link between sleep, thermoregulation and food intake and (ii) how the hypothalamic structures affect the functional interactions between processes involved in regulation of the body’s energy balance. In 10 freely moving rats, the liver was heated artificially to and maintained at set‐point temperatures of 39.5, 40.0 and 40.5 °C for 4 h. Each animal’s feeding activity, cortical temperature and brown adipose tissue (TBAT) temperature were measured continuously. Sleep organization and wakefulness were scored from electroencephalograms. Each animal served as its own control. Heating the liver induced a decrease in food intake and TBAT, corresponding to the development of a hypometabolic hypothermic status. The total amounts of wakefulness and rapid eye movement sleep fell, whereas the total amount of slow wave sleep increased accordingly. Our findings show that the liver is involved significantly in the body’s thermodynamic equilibrium. The organ’s thermal status can induce well‐coordinated behavioural and autonomic adaptive responses involved in the control of food intake and in the maintenance of body homeothermia. Our study provides indirect evidence of the existence of hepatic thermosensors afferent to feeding and sleeping hypothalamic integrating centres that can be stimulated by physiological increases in liver temperature.

show abstract

“…During heating sessions, the liver temperature always remained within the physiological range (Adachi et al. , 1991; Di Bella et al. , 1981; Toutain et al.…”

Section: Discussionmentioning

confidence: 99%

Section: Liver Heatingmentioning

confidence: 99%

Section: Study Limitationsmentioning

confidence: 99%

“…Many studies have shown that the liver temperature influences food intake and metabolism (De Vries et al. , 1993; Di Bella et al. , 1981; Himms‐Hagen, 1995).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations