Behavioral, neurochemical and neuroendocrine effects of the ethanolic extract from Curcuma longa L. in the mouse forced swimming test

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

“…These have consistently demonstrated that both acute (Arora et al, 2011;Chimakurthy and Talasila, 2010;Gilhotra and Dhingra, Antidepressant Potential Modes of Action of Curcumin 2010; Kulkarni et al, 2008;Sanmukhani et al, 2011;Wang et al, 2008) and chronic (Bhutani et al, 2009;Huang et al, 2011;Li et al, 2009;Sanmukhani et al, 2011;Xia et al, 2007;Xu et al, 2005b) administration of curcumin to rats and mice reduces immobility time.…”

Curcumin for the treatment of major depression: A randomised, double-blind, placebo controlled study

“…More specifically, curcumin is a potent antioxidant that can lower markers of oxidative stress (Naik et al, 2011, Rai et al, 2010, modulate immuno-inflammation by acting as a COX-2 inhibitor (Lee et al, 2011, Plummer et al, 1999 and lower pro-inflammatory cytokines (Basnet andSkalko-Basnet, 2011, Belcaro et al, 2010), provide significant neuroprotection , Xu et al, 2007, modulate HPA activity , Li et al, 2009) and influence monoamine transmission through its effect on serotonergic and dopaminergic activity (Bhutani et al, 2009, Kulkarni et al, 2008, Xia et al, 2007. In animal studies, antidepressant effects of curcumin have been attributed to its serotonergic, dopaminergic, neuroprotective and HPA-modulating effects , Kulkarni et al, 2008, Xu et al, 2006.…”

Protective effect of curcumin against cardiac dysfunction in sepsis rats

“…Curcumin (CUM) is the major curcuminoid of rhizome Siddiqui et al, 2006;Xia et al, 2007;Singh et al, 2010). CUM is a hydro-phobic polyphenol and is responsible for the yellow color of the rhizome, and has wide spectrum pharmacological activities as turmeric, such as anticancer, antiinflammatory, antibacterial, antioxidant, antirheumatic, choleretic, etc.…”