Curcumin for the treatment of major depression: A randomised, double-blind, placebo controlled study

Lopresti, Adrian L.; Maes, Michael; Maker, Garth; Hood, Sean; Drummond, Peter D.

doi:10.1016/j.jad.2014.06.001

Cited by 157 publications

(106 citation statements)

References 50 publications

(44 reference statements)

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“…This is corroborated by reports that nutraceuticals with anti-inflammatory and anti-O&NS effects, which multi-target these pathways [e.g. ω3 PUFAs, zinc, N-acetyl cysteine and curcumin] may have a clinical efficacy in depression and reduce depressive-like behaviors in animal models [4,[78][79][80][81].…”

Section: Gaps and Required Improvements: New Treatmentssupporting

confidence: 65%

Toward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research

et al. 2015

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Meta-analyses confirm that depression is accompanied by signs of inflammation including increased levels of acute phase proteins, e.g. C-reactive protein, and pro-inflammatory cytokines, e.g. interleukin-6. Supporting the translational significance of this, a meta-analysis showed that anti-inflammatory drugs may have antidepressant effects. Here we argue that inflammation and depression research needs to get onto a new track. Firstly, the choice of inflammatory biomarkers in depression research was often too selective and did not consider the broader pathways.Secondly, although mild inflammatory responses are present in depression, other immune-related pathways cannot be disregarded as new drug targets, e.g. activation of cell-mediated immunity, oxidative and nitrosative stress (O&NS) pathways, autoimmune responses, bacterial translocation, activation of the Toll-like Receptor and neuroprogressive pathways. Thirdly, antiinflammatory treatments are sometimes used without full understanding of their effects on the broader pathways underpinning depression. Since many of the activated immune-inflammatory pathways in depression actually confer protection against an overzealous inflammatory response, targeting these pathways may result in unpredictable and unwanted results. Furthermore, this paper discusses the required improvements in research strategy, i.e. path and drug discovery processes, omics-based techniques and systems biomedicine methodologies. Firstly, novel methods should be employed to examine the intracellular networks that control and modulate the immune, O&NS and neuroprogressive pathways using omics-based assays, including genomics, transcriptomics, proteomics, metabolomics, epigenomics and microbiomics. Secondly, systems biomedicine analyses are essential to unravel the complex interactions between these cellular 4 networks, pathways and the multifactorial trigger factors and to delineate new drug targets in the cellular networks or pathways. Drug discovery processes should delineate new drugs targeting the intracellular networks and immune-related pathways.

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Section: Gaps and Required Improvements: New Treatmentssupporting

confidence: 65%

Toward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research

et al. 2015

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“…In addition, other nutraceuticals with significant antioxidant activity that merit investigation in ADHD treatment trials include curcumin, green tea and resveratrol. The psychotropic effects of curcumin, in particular, are intriguing, and there has been some support for it efficacy in the treatment of depression (Lopresti et al 2014). Because of demonstrated vitamin D deficiencies in people with ADHD, supplementation with this vitamin and/or replenishment via sunlight exposure is an additional area requiring investigation.…”

Section: The Potential For Antioxidant-related Therapies In Adhdmentioning

confidence: 99%

Oxidative and nitrosative stress in ADHD: possible causes and the potential of antioxidant-targeted therapies

Lopresti

2015

ADHD Atten Def Hyp Disord

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Attention deficit hyperactivity disorder (ADHD) has a complex etiology although theories associated with disturbances in dopaminergic and noradrenergic activity are most commonly cited.The importance of these catecholamines in ADHD is supported by its effective treatment utilising stimulant and non-stimulant medications that modify their activity. Recently there has been interest in oxidative and nitrosative stress (O&NS) in ADHD and its potential to contribute to this condition. In this article, research investigating O&NS in ADHD is reviewed and its impact on catecholaminergic activity and neurological structure is discussed. Lifestyle, environmental, ADHD is most commonly treated with stimulant medications such as methylphenidate and amphetamines, non-stimulants such as atomoxetine, and alpha2-adrenergic agonists such as clonidine and guanfacine. Through their effects on dopamine and noradrenaline transporters, stimulants inhibit the reuptake of dopamine and noradrenaline, thereby increasing the extracellular levels of these neurotransmitters. These stimulants also inhibit monoamine oxidase, the enzyme that metabolises these catecholamines (Wilens et al. 2011). Atomoxetine works as a selective reuptake inhibitor of noradrenaline leading to its increased extracellular concentration (Garnock- Jones and Keating 2009).While effective, these medications are associated with several adverse effects. These include loss of appetite, growth delay and sleep disturbances (Cortese et al. 2013). It is important to note that despite their widely accepted short-term efficacy, the long-term effectiveness of pharmacological treatments on social, educational and occupational functioning in people with ADHD continues to be debated (Huang and Tsai 2011;Langberg and Becker 2012;Nijmeijer et al. 2008). On a positive note, recent analyses using the Swedish national registrar suggests that long-term stimulant use in people with ADHD is associated with reduced rates of substance use, criminality, and serious traffic accidents (Chang et al. 2014a;Chang et al. 2014b;Lichtenstein et al. 2012).Despite wide appreciation of catecholaminergic theories associated with ADHD, there has been increased research into other biological mechanisms associated with ADHD. For example, in psychiatry there has been interest in immune-inflammatory pathways and oxidative and nitrosative stress (O&NS). In particular, it has been confirmed through recent meta-analyses that depression is Increased O&NS has also been found in bipolar disorder (Andreazza et al. 2008;Brown et al. 2014),

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“…[52] The study was carried out for 8 weeks. Betterment in the Inventory of Depressive Symptomatology self-rated version (IDS-SR30) was employed as the primary outcome.…”

Section: Curcumin On Depression:-mentioning

confidence: 99%

“…Betterment in the Inventory of Depressive Symptomatology self-rated version (IDS-SR30) was employed as the primary outcome. [52] The secondary outcomes used to assess effect of curcumin were IDS-SR30 factor scores and the Speilberger State-Trait Anxiety Inventory (STAI).Though there was no significant difference between the two groups in the first four weeks in decreasing depressive and anxiety symptoms , from week 4 to 8,the curcumin group was more efficacious than placebo in bringing down both depressive and anxiety symptoms as shown by improvement in IDS-SR30 total score and IDS-SR30 mood score [52] Curcuma longa was found to inhibit MAO A in mouse brain, which is responsible for its antidepressant effects [53].…”

Section: Curcumin On Depression:-mentioning

confidence: 99%

The Pleiotropic Effects of Curcumin.

Srinivasan¹,

Selvarajan²,

Dkhar³

2017

IJAR

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Curcumin for the treatment of major depression: A randomised, double-blind, placebo controlled study

Abstract: BACKGROUND: Curcumin, the principal curcuminoid derived from the spice turmeric, influences several

Cited by 157 publications

References 50 publications

Toward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research

Toward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research

Oxidative and nitrosative stress in ADHD: possible causes and the potential of antioxidant-targeted therapies

The Pleiotropic Effects of Curcumin.

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