Behavioral models of binge-type eating

Corwin, Rebecca L.; Buda-Levin, Ariel

doi:10.1016/j.physbeh.2004.04.036

Cited by 172 publications

(184 citation statements)

References 70 publications

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“…Currently available animal models of bingeing-related eating disorders are isomorphic, sharing the common feature of binge episodes that occur repeatedly over extended periods of time, but vary in their similarities to human disordered binge-type eating. 50 For an example, Corwin model with limited access to forbidden food 51 is relevant to bingeing in the absence of hunger in humans. 52 The present model may have specific relevance to the hypersensitive response of the HPA axis in patients with bingeing-related eating disorders, 4,53 which is associated with childhood trauma.…”

Section: Discussionmentioning

confidence: 99%

Sustained hyperphagia in adolescent rats that experienced neonatal maternal separation

et al. 2008

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Objective: To examine the neurobiological basis of bingeing-related eating disorders using an animal model system. Design: Sprague-Dawley pups were separated from dam for 3 h daily during the first two weeks of birth (maternal separation (MS)), or left undisturbed (non-handled (NH)). Pups were subjected to repeated fasting/refeeding (RF) cycles; that is, 24 h food deprivation and 24 h RF (NH/RF or MS/RF), or had free access to food and water (NH/fed control (FC) or MS/FC) from postnatal day (PND) 28-40. Measurements: Body weight gain and food intake were recorded. The arcuate expression of neuropeptide Y (NPY) and plasma corticosterone levels were analyzed on PND 29 and 40. Results: Decrease in weight gain by repeated fasting/RF cycles was smaller in MS pups than in NH. Interestingly, weight changes responding to fasting or RF increased in MS/RF compared with NH/RF. Compensatory hyperphagia was diminished in NH/RF after the third fasting trial, but persisted in MS/RF throughout the experimental period. The arcuate expression of NPY mRNA responding to food deprivation was blunted, but elevation of plasma corticosterone exaggerated, in the MS group, compared to the NH group, on PND 29 after the first fasting session. However, both the arcuate NPY mRNA and plasma corticosterone levels were increased in MS/RF, but not in NH/RF, on PND 40 after the six sets of fasting/RF cycles, compared to the free FC groups. Conclusion: Experience of neonatal MS may lead to an exaggerated feeding response to repeated fasting/RF challenges at adolescence, perhaps, due to increased responsiveness of the hypothalamic-pituitary-adrenal gland axis. Additionally, the results suggested that an increased action of the hypothalamic NPY may not be necessary to induce compensatory hyperphagia following food deprivation.

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Section: Discussionmentioning

confidence: 99%

Sustained hyperphagia in adolescent rats that experienced neonatal maternal separation

et al. 2008

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“…Obesity is associated with two eating disorders: bingeeating disorder (BED) (Corwin and Buda-Levin 2004) and night-eating syndrome (NES) (Stunkard and Allison 2003b). Binge eating is defined as "eating during a discrete period of time (e.g.…”

Section: Obesity Is Associated With Disordered Eatingmentioning

confidence: 99%

“…within any 2 hour period), an amount of food that is definitely larger than most people would eat during a similar period of time under similar circumstances" (DSM 2000). Binge eating is a complex behavior associated with feelings of loss of control, disgust, guilt, depression, and embarrassment (Corwin and Buda-Levin 2004). Both BED and BN are characterized by binge eating.…”

Section: Obesity Is Associated With Disordered Eatingmentioning

confidence: 99%

“…The mechanisms underlying binge eating and the physiologic and neural effects of binge eating are not well understood nor easily studied in humans; thus, the development of animal models of binge eating is important (Corwin and Buda-Levin 2004;Yanovski 1995). As in BN, modeling emotional afflictions such as distress and loss of control are difficult in animals; thus, most of the animal models of BED strive to mimic the central behavioral feature of the disorder: binge eating.…”

Section: Animal Models Of Bedmentioning

confidence: 99%

“…As in BN, modeling emotional afflictions such as distress and loss of control are difficult in animals; thus, most of the animal models of BED strive to mimic the central behavioral feature of the disorder: binge eating. The animal models of binge eating are described in detail in the animal models of "Bulimia nervosa" section and include animal models where binging is induced by sham-feeding using a gastric fistula, acute (foot shock, tail pinch) and chronic (space restriction and maternal separation) stressors, cycles of food restriction, and limited access to highly palatable food (Corwin and Buda-Levin 2004). …”

Section: Animal Models Of Bedmentioning

confidence: 99%

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Relevance of animal models to human eating disorders and obesity

2008

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Background and rationale This review addresses the role animal models play in contributing to our knowledge about the eating disorders anorexia nervosa (AN) and bulimia nervosa (BN) and obesity. Objectives Explore the usefulness of animal models in complex biobehavioral familial conditions, such as AN, BN, and obesity, that involve interactions among genetic, physiologic, psychological, and cultural factors. Results and conclusionsThe most promising animal model to mimic AN is the activity-based anorexia rodent model leading to pathological weight loss. The paradigm incorporates reward elements of the drive for activity in the presence of an appetite and allows the use of genetically modified animals. For BN, the sham-feeding preparation in rodents equipped with a gastric fistula appears to be best suited to reproduce the postprandial emesis and the defects in satiety. Animal models that incorporate genes linked to behavior and mood may clarify biobehavioral processes underlying AN and BN. By contrast, a relative abundance of animal models has contributed to our understanding of human obesity. Both environmental and genetic determinants of obesity have been modeled in rodents. Here, we consider single gene mutant obesity models, along with models of obesigenic environmental conditions. The contributions of animal models to obesity research are illustrated by their utility for identifying genes linked to human obesity, for elucidating the pathways that regulate body weight and for the identification of potential therapeutic targets. The utility of these models may be further improved by exploring the impact of experimental manipulations on the behavioral determinants of energy balance.

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Binge Eating in Rats with Limited Access to Vegetable Shortening

Corwin

Wojnicki

2006

CP Neuroscience

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In this protocol, binge-type eating is induced in non-food-deprived rats by providing limited access to an optional source of dietary fat: vegetable shortening. The protocol is simple and inexpensive, and the binge behavior is robust, reliable, and maintainable across extended periods of time. Two peptides that normally affect fat intake in rats have no effect on fat intake under limited-access conditions. However, recent results with a GABA(B) receptor agonist and with progressive-ratio responding suggest that the behavior induced by the limited-access binge protocol may share similarities with substance abuse. This protocol is designed to model the kind of excessive behavior that characterizes bingeing-related eating disorders and certain addictions.

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Behavioral models of binge-type eating

Cited by 172 publications

References 70 publications

Sustained hyperphagia in adolescent rats that experienced neonatal maternal separation

Sustained hyperphagia in adolescent rats that experienced neonatal maternal separation

Relevance of animal models to human eating disorders and obesity

Binge Eating in Rats with Limited Access to Vegetable Shortening

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