Behavioral despair associated with a mouse model of Crohn's disease: Role of nitric oxide pathway

Heydarpour, Pouria; Rahimian, Reza; Fakhfouri, Gohar; Khoshkish, Shayan; Fakhraei, Nahid; Salehi-Sadaghiani, Mohammad; Wang, Hongxing; Abbasi, Ata; Dehpour, Ahmad Reza; Ghia, Jean–Eric

doi:10.1016/j.pnpbp.2015.08.004

Cited by 42 publications

(41 citation statements)

References 96 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, mice with Crohn's disease demonstrated a significantly higher immobility time in the forced swimming test associated with a significant elevation in iNOS expression and nitrite content. However, acute NOS inhibition decreased the immobility time in colitic mice (Heydarpour et al 2016). Collectively, the previous work suggests that elevated serum NO level is associated with depressive-like behavior.…”

Section: Discussionmentioning

confidence: 59%

See 1 more Smart Citation

Neuroprotective effect of nebivolol against cisplatin‐associated depressive‐like behavior in rats

Abdelkader

Saad

Abdelsalam

2017

Journal of Neurochemistry

View full text Add to dashboard Cite

One-third of cancer patients undergoing chemotherapy treatment often display symptoms of depression leading to poor adherence and decreased quality of life. Thus, this study aimed to investigate the possible protective effect of nebivolol against cisplatin-associated depressive symptoms in adult male rats. Nebivolol is a highly cardioselective β-adrenergic receptor blocker that possesses endothelium-dependent vasodilator properties and antioxidant capacities. Animals were allocated into four groups. Group one was given aqueous solution of carboxymethyl cellulose and served as control, group two was given nebivolol (10 mg/kg p.o., daily), group three was given cisplatin (2 mg/kg i.p. once per week) for 10 consecutive weeks and group four was treated with cisplatin concomitantly with nebivolol as per above schedule. Cisplatin-treated rats showed an increase in both depressive-like behaviors in open-field and forced swimming tests. In addition, histopathological examination revealed cortical encephalomalacia along with hippocampal neuronal degeneration and kidney dysfunction. In parallel, cisplatin administration prominently reduced GABA and elevated glutamate levels in the cortical and hippocampal tissues. Furthermore, it resulted in a significant decline in cortical and hippocampal brain-derived neurotrophic factor and nitric oxide contents concomitantly with a marked decrease in endothelial- and an increase in inducible-nitric oxide synthase genes expression. On the other hand, treatment with nebivolol effectively mitigated the aforementioned cisplatin-associated behavioral, biochemical, and histopathological alterations without changing its antitumor activity as evidenced by sulforhodamine B cell survival assay. Taken together, our results suggest that nebivolol may offer a promising approach for alleviating depressive symptoms associated with the use of cisplatin.

show abstract

Section: Discussionmentioning

confidence: 59%

“…However, acute NOS inhibition decreased the immobility time in colitic mice (Heydarpour et al . ). Collectively, the previous work suggests that elevated serum NO level is associated with depressive‐like behavior.…”

Section: Discussionmentioning

confidence: 97%

Neuroprotective effect of nebivolol against cisplatin‐associated depressive‐like behavior in rats

Abdelkader

Saad

Abdelsalam

2017

Journal of Neurochemistry

View full text Add to dashboard Cite

show abstract

“…Indeed, NR2B subunit has been shown to be a crucial component for LTP induction (Muller et al, 2009), therefore supporting findings in colitis rats for the involvement of NR2B in regulating LTP activity. Interestingly, a similar colitis model was also shown to induce behavioural despair and depressive-like behaviours in mice, proposing this model as a relevant example of inflammation-induced depression, where LTP might be one of the mechanisms mediating the relationship between inflammation-dependendent microglial activation and subsequent development of depression (Heydarpour et al, 2016).…”

Section: Inflammation-mediated Microglial Modification Of Ltpmentioning

confidence: 97%

Microglial-driven changes in synaptic plasticity: A possible role in major depressive disorder

Innes

Pariante

Borsini

2019

Psychoneuroendocrinology

View full text Add to dashboard Cite

show abstract

“…Anxiety-/depression-like behavioural alterations. In a recent study, Heydarpour et al (97) show an increase in immobility in the forced swimming test (FST), a depression-related behaviour in mice 3 days post-TNBS injection. This effect is attenuated using a specific inducible nitric oxide synthase (iNOS) inhibitor (aminoguanidine) administered 30 min before the FST indicating the potential involvement of the nitric oxide pathway in the induction of this behaviour.…”

Section: Cns Disturbances In Models Of Ibdmentioning

confidence: 99%

Gut–brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease

Abautret-Daly

Dempsey

Parra‐Blanco

et al. 2017

Acta Neuropsychiatr.

139

107

View full text Add to dashboard Cite

show abstract

Behavioral despair associated with a mouse model of Crohn's disease: Role of nitric oxide pathway

Cited by 42 publications

References 96 publications

Neuroprotective effect of nebivolol against cisplatin‐associated depressive‐like behavior in rats

Neuroprotective effect of nebivolol against cisplatin‐associated depressive‐like behavior in rats

Microglial-driven changes in synaptic plasticity: A possible role in major depressive disorder

Gut–brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease

Contact Info

Product

Resources

About