Gut–brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease

Abautret-Daly, Áine; Dempsey, Elaine; Parra‐Blanco, Adolfo; Medina, Carlos; Harkin, Andrew

doi:10.1017/neu.2017.3

Cited by 140 publications

(122 citation statements)

References 175 publications

(211 reference statements)

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“…Multiple lines of evidence increasingly point towards a role of environmental factors and disrupted gut-brain axis function both in many neuropsychiatric disorders, including depression, and in gastrointestinal disorders, including IBS [19,[91][92][93]. The wide range of factors involved in the disturbances are considered, including changes in the mucosal immune system, the microbiota dysbioses and amounts of short chain fatty acids dependent on microbiota, exposure to xenobiotics, gut permeability, food IgG antibodies [91][92][93][94][95].…”

Section: Discussionmentioning

confidence: 99%

Nutrition and the Function of the Central Nervous System

2018

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Section: Discussionmentioning

confidence: 99%

Nutrition and the Function of the Central Nervous System

2018

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“…On the other hand, IBD patients with IBD seem to present more aggressive phenotypes of the disease, with more relapses and shorter periods of remission [52]. In any case, the prevalence of depression or anxiety is even higher when other psychiatric conditions coexist [1,52,53].…”

Section: Psychiatric Disordersmentioning

confidence: 99%

“…In this regard, a dysfunction of the immune system and a chronic inlammatory response appear both in the context of a speciic environmental situation and in a genetically predisposed patient [1]. However, bearing in mind the physiopathology of neurological manifestations, there are diferent mechanisms that may speciically be involved in their development [4]:…”

Section: General Pathophysiological Considerations Of Ibd and Its Neumentioning

confidence: 99%

“…IBD patients show a high prevalence of psychiatric disorders, with depression and anxiety as the main diagnosis [1,52,53]. The prevalence of depression in IBD patients varies from 15 to 30%, but the frequency of anxiety rises to 80%, mainly associated with the relapses of the disease [54,55].…”

Section: Psychiatric Disordersmentioning

confidence: 99%

“…Inlammatory bowel disease (IBD) is a chronic disease of the gastrointestinal tract with an unknown etiology, which alternates between periods of symptoms relapse and remission [1,2]. IBD involves various entities.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neurological Manifestations of Inflammatory Bowel Disease

Plata‐Bello¹,

Acosta-López²

2018

New Concepts in Inflammatory Bowel Disease

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The inlammatory bowel disease (IBD) is associated with diferent neurological and psychiatric disorders, which are integrated among the extra-intestinal manifestation of this disease. The physiopathology of neurological manifestations of IBD varies among the diferent kind of complications. The origin and the signiicance of these manifestations must be understood by clinicians who manage IBD patients. Some of them are related to therapeutic agents. The present chapter consists of a review of the most prevalent neurological and psychiatric disorders associated with IBD. The physiopathology of those entities will also be discussed, as well as the appropriate management for their prevention and treatment.

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Microalgae‐Based Hydrogel for Inflammatory Bowel Disease and Its Associated Anxiety and Depression

Zhong,

Jin,

Wang

et al. 2024

Advanced Materials

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Patients diagnosed with inflammatory bowel disease (IBD) exhibit a notable prevalence of psychiatric disorders, such as anxiety and depression. Nevertheless, the etiology of psychiatric disorders associated with IBD remains uncertain, and an efficacious treatment approach has yet to be established. Herein, we propose an oral hydrogel strategy (SP@Rh‐gel) for co‐delivery of Spirulina platensis and rhein to treat IBD and IBD‐associated anxiety and depression by modulating the microbiota‐gut‐brain axis. SP@Rh‐gel improves the solubility, release characteristics and intestinal retention capacity of the drug, leading to a significant improvement in the oral therapeutic efficacy. Oral administration of SP@Rh‐gel inhibits NF‐κB‐caspase‐1 signaling pathway to reduce intestinal inflammation and rebalances the disrupted intestinal microbial community to maintain intestinal homeostasis. Furthermore, SP@Rh‐gel maintains intestinal barrier integrity and reduces the release of pro‐inflammatory cytokines and lipopolysaccharides and their entry into the hippocampus through the blood‐brain barrier, thereby inhibiting neuroinflammation and maintaining neuroplasticity. SP@Rh‐gel significantly alleviates the colitis symptoms, as well as anxiety‐ and depression‐like behaviors, in a chronic colitis mouse model. This study demonstrates the significant involvement of the microbiota‐gut‐brain axis in the development of IBD with psychiatric disorders and proposes a safe, simple, and highly efficient therapeutic approach for managing IBD and comorbid psychiatric disorders.This article is protected by copyright. All rights reserved

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Gut–brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease

Abstract: It is recommended that patients with IBD be screened for psychological disturbance and treated accordingly as intervention can improve quality of life and may reduce relapse rates.

Cited by 140 publications

References 175 publications

Nutrition and the Function of the Central Nervous System

Nutrition and the Function of the Central Nervous System

Neurological Manifestations of Inflammatory Bowel Disease

Microalgae‐Based Hydrogel for Inflammatory Bowel Disease and Its Associated Anxiety and Depression

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