Behavioral deficits induced by lead exposure are accompanied by serotonergic and cholinergic alterations in the prefrontal cortex

Lead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood

“…41 In animal models, sex-specific differences in the effects of Pb exposure have also been observed in spatial learning and memory, motor behavior, dopamine metabolism, and brain gene expression. 8,42,43 Some of the sex-biased response to Pb toxicity can be attributed to sex hormones, or to the differential expression of sex and/or autosomal genes. 44 A mechanism through which exposure to heavy metals such as Pb might contribute to altering gene expression is by changing the 5hmC and 5mC profiles in the genome.…”

Serum Neuron-Specific Enolase, Biogenic Amino-Acids and Neurobehavioral Function in Lead-Exposed Workers from Lead-Acid Battery Manufacturing Process

“…Deficiencies of monoamine degradation lead to cognitive, behavioral and autonomic disorders. 41 Mansouri,et al,17 reported that extracellular dopamine concentration was unaffected and serotonin concentration decreased in rats exposed to lead. Lead exposure caused a significant decrease in dopamine, 18 the levels of norepinephrine, dopamine, and serotonin in different brain regions were also altered after lead exposure.…”

“…14 Low levels of serotonin have associated with impulsive behaviors and deregulations of dopamine systems. 15 Animal studies reported that lead exposure altered motor behavior and the synaptosomal aminergic system, 16 decreased serotonin in brain, [17][18][19] increased dopamine in the basal ganglia, 20 and decreased activity of neurotransmitters that ultimately affected the locomotive and cognitive functions. 21 Increased number of errors, high response time in the symbol digit test, impaired memory, 22 and poor scores in profile of mood states, tension-anxiety, hostility, and depression 23 have been reported in lead smelter workers.…”

The Use of Intracerebral Microdialysis to Elucidate Environmentally Induced Neurotoxic Mechanisms

“…Mansouri, Naghizadeh, Lopez‐Larrubia, and Cauli () examined chronic lead exposure in adult rats that produced blood lead concentrations below those producing overt neurological deficits in occupationally exposed workers. Microdialysis was employed to assess biogenic amine neurotransmitter activity.…”