Behavioral correlates of self-stimulation, flight and ambivalence

St-Laurent, Jacques

doi:10.1016/0361-9230(88)90121-9

Cited by 9 publications

(2 citation statements)

References 42 publications

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“…All three patients fulfilled DSM-IV diagnostic criteria for manic disorder due to a general medical condition 2 because all had the classic features of mania (i.e., elation, overactivity, grandiose delusions) in the absence of impaired consciousness or hallucinations. 9 The fact that in all three cases manic episodes were observed only after the stimulation was turned "on," the recurrence of the manic syndrome after repeating the stimulation with the lower right contact, coupled with the disappearance of the manic state after modifying the stimulation to higher contacts in Patient 1 lend support to a stimulation effect. The artifact induced by the electrodes makes the exact position of the tip of the electrode uncertain (figure).…”

mentioning

confidence: 79%

Mania following deep brain stimulation for Parkinson’s disease

Kulisevsky

Berthier²,

Gironell³

et al. 2002

Neurology

241

146

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Three patients with PD developed manic behavior after bilateral implantation of electrodes for deep-brain stimulation (DBS). Common to all three patients were manic symptoms unremitting after levodopa reduction or stimulation "off," lower electrodes positioning caudal to the subthalamic nucleus area, postoperative DBS with the lower contacts (0) of the quadripolar electrodes, and resolution of the manic episodes coinciding with stimulation through higher contacts.

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mentioning

confidence: 79%

Mania following deep brain stimulation for Parkinson’s disease

Kulisevsky

Berthier²,

Gironell³

et al. 2002

Neurology

241

146

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“…Serotonin appears to exert a modulating function on the amplitude of physiological responses and therefore on behaviour (Jacobs and Jones 1978). Stimulation studies have indicated that the midbrain raphe is involved in behavioural phenomena consisting of approach and ambivalence accompanied by what, at first, appeared as disruptive behaviours and other complex behaviour (St Laurent 1988). Moreover, the activity of serotonergic neurons is closely related to SWC and to certain specific types of repetitive motor activity (Jacobs 1991).…”

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confidence: 99%

Centralis superior raphe, reticularis pontis nuclei, and sleep‐wakefulness cycle in cats

Arpa

Padrino²,

Rodriguez-Albariño³

et al. 1998

Journal of Sleep Research

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SUMMARYThis study examines the influence of lesions in the centralis superior raphe nucleus (CeSR) and adjacent paramedial pontine tegmentum on the sleep/wakefulness cycle (SWC) in cats. Sixteen cats had electrodes implanted for electro-oculogram (EOG), electromyogram (EMG), electroencephalogram (EEG) and ponto-geniculo-occipital (PGO) recordings. There were 10 experimental animals: seven animals received diathermocoagulation lesions destroying between 7 and 27% of the CeSR; the remaining three cats suffered bilateral lesions in the paramedial portion of the reticularis pontis oralis (RPO) and caudalis (RPC) nuclei. Six sham-operated animals were used as controls. Recordings were taken of all animals in continuous 23-h sessions once a week for 12 weeks. Results indicated that the threshold for SWC state changes (increase of wakefulness (W) and drowsiness (D), and decrease of slow wave sleep (SWS)) after CeSR lesion is approximately 11.3% following volumetric destruction of the nucleus. The amount of CeSR damage (CeSR-D) only correlated significantly with the amount of W (positive correlation) and SWS (negative correlation) during the first week post-lesion. The changes in W over the course of the study were different in the two experimental groups. In both groups, total W was increased with respect to the controls, however, these increases were observed earlier in the CeSR-D group. The return to near control values in SWC state over days 15-28 of the study does not represent a definitive recovery by the CeSR-D cats. All the SWC states returned to control values by the tenth week in the cats with paramedial reticular pontine damage.

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The relationship between self-stimulation and sniffing in rats: does a common brain system mediate these behaviors?

Ikemoto

Panksepp

1994

Behavioural Brain Research

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Behavioral correlates of self-stimulation, flight and ambivalence

Cited by 9 publications

References 42 publications

Mania following deep brain stimulation for Parkinson’s disease

Mania following deep brain stimulation for Parkinson’s disease

Centralis superior raphe, reticularis pontis nuclei, and sleep‐wakefulness cycle in cats

The relationship between self-stimulation and sniffing in rats: does a common brain system mediate these behaviors?

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