Behavioral correlates of negative BOLD signal changes in the primary somatosensory cortex

Kastrup, Andreas; Baudewig, Jürgen; Schnaudigel, Sonja; Huonker, Ralph; Becker, Lars; Sohns, Jan M; Dechent, Peter; Klingner, Carsten M.; Witte, Otto W.

doi:10.1016/j.neuroimage.2008.03.049

Cited by 114 publications

(150 citation statements)

References 42 publications

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“…NBRs are observed in many human fMRI studies (Shmuel et al, 2002;Smith et al, 2004;Northoff et al, 2007;Pasley et al, 2007;Kastrup et al, 2008). Interestingly, positive BOLD responses above baseline after stimulus cessation were also reported (Shmuel et al, 2002).…”

Section: Human Studiesmentioning

confidence: 82%

“…Third, in visual cortex a tight coupling between CBF and cerebral metabolic rate of oxygen consumption during evoked responses under conditions of resting and negative BOLD suggests that NBRs provide a reliable index of suppressed neural activity (Pasley et al, 2007). Fourth, increases in somatosensory perception thresholds caused by inhibition induced by contralateral activation were associated with NBRs (Kastrup et al, 2008). Finally, a spectroscopy study (Northoff et al, 2007) reported regional correlations between levels of the inhibitory neurotransmitter GABA and NBR.…”

Section: Human Studiesmentioning

confidence: 99%

“…An often observed but less frequently reported fMRI signal in both human (Shmuel et al, 2002;Smith et al, 2004;Northoff et al, 2007;Pasley et al, 2007;Kastrup et al, 2008) and animal investigations (Harel et al, 2002;Shmuel et al, 2006;Alonso Bde et al, 2008) is a negative BOLD response (NBR). It is usually, but not exclusively found in regions adjacent to areas of increased BOLD activity.…”

Section: Introductionmentioning

confidence: 99%

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Negative Blood Oxygen Level Dependence in the Rat:A Model for Investigating the Role of Suppression in Neurovascular Coupling

Boorman¹,

Kennerley²,

Johnston³

et al. 2010

J. Neurosci.

147

144

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Modern neuroimaging techniques rely on neurovascular coupling to show regions of increased brain activation. However, little is known of the neurovascular coupling relationships that exist for inhibitory signals. To address this issue directly we developed a preparation to investigate the signal sources of one of these proposed inhibitory neurovascular signals, the negative blood oxygen level-dependent (BOLD) response (NBR), in rat somatosensory cortex. We found a reliable NBR measured in rat somatosensory cortex in response to unilateral electrical whisker stimulation, which was located in deeper cortical layers relative to the positive BOLD response. Separate optical measurements (two-dimensional optical imaging spectroscopy and laser Doppler flowmetry) revealed that the NBR was a result of decreased blood volume and flow and increased levels of deoxyhemoglobin. Neural activity in the NBR region, measured by multichannel electrodes, varied considerably as a function of cortical depth. There was a decrease in neuronal activity in deep cortical laminae. After cessation of whisker stimulation there was a large increase in neural activity above baseline. Both the decrease in neuronal activity and increase above baseline after stimulation cessation correlated well with the simultaneous measurement of blood flow suggesting that the NBR is related to decreases in neural activity in deep cortical layers. Interestingly, the magnitude of the neural decrease was largest in regions showing stimulus-evoked positive BOLD responses. Since a similar type of neural suppression in surround regions was associated with a negative BOLD signal, the increased levels of suppression in positive BOLD regions could importantly moderate the size of the observed BOLD response.

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Section: Human Studiesmentioning

confidence: 82%

Section: Human Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Negative Blood Oxygen Level Dependence in the Rat:A Model for Investigating the Role of Suppression in Neurovascular Coupling

Boorman¹,

Kennerley²,

Johnston³

et al. 2010

J. Neurosci.

147

144

View full text Add to dashboard Cite

show abstract

“…Therefore, accounting for the hemodynamic delay, this reduction in neuronal activity is a highly plausible source of the BOLD poststimulus undershoot. Furthermore, in regions where the primary BOLD response to the stimulus decreased compared with baseline levels (negative BOLD response) (20,21), the neuronal activity following stimulus cessation increased above baseline, causing a BOLD poststimulus overshoot (19). A poststimulus overshoot following a negative primary BOLD response has also been reported in human visual (21) and somatosensory (20) cortices.…”

mentioning

confidence: 88%

“…Furthermore, in regions where the primary BOLD response to the stimulus decreased compared with baseline levels (negative BOLD response) (20,21), the neuronal activity following stimulus cessation increased above baseline, causing a BOLD poststimulus overshoot (19). A poststimulus overshoot following a negative primary BOLD response has also been reported in human visual (21) and somatosensory (20) cortices. Shmuel et al (19) proposed that a decrease (increase) in neuronal activity triggering a decrease (increase) in CBF may underlie the BOLD poststimulus undershoot (overshoot), providing further support for mechanism iii.…”

mentioning

confidence: 88%

Poststimulus undershoots in cerebral blood flow and BOLD fMRI responses are modulated by poststimulus neuronal activity

Mullinger

Mayhew

Bagshaw

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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fMRI is the foremost technique for noninvasive measurement of human brain function. However, its utility is limited by an incomplete understanding of the relationship between neuronal activity and the hemodynamic response. Though the primary peak of the hemodynamic response is modulated by neuronal activity, the origin of the typically negative poststimulus signal is poorly understood and its amplitude assumed to covary with the primary response. We use simultaneous recordings of EEG with blood oxygenation level-dependent (BOLD) and cerebral blood flow (CBF) fMRI during unilateral median nerve stimulation to show that the poststimulus fMRI signal is neuronally modulated. We observe high spatial agreement between concurrent BOLD and CBF responses to median nerve stimulation, with primary signal increases in contralateral sensorimotor cortex and primary signal decreases in ipsilateral sensorimotor cortex. During the poststimulus period, the amplitude and directionality (positive/negative) of the BOLD signal in both contralateral and ipsilateral sensorimotor cortex depends on the poststimulus synchrony of 8-13 Hz EEG neuronal activity, which is often considered to reflect cortical inhibition, along with concordant changes in CBF and metabolism. Therefore we present conclusive evidence that the fMRI time course represents a hemodynamic signature of at least two distinct temporal phases of neuronal activity, substantially improving understanding of the origin of the BOLD response and increasing the potential measurements of brain function provided by fMRI. We suggest that the poststimulus EEG and fMRI responses may be required for the resetting of the entire sensory network to enable a return to resting-state activity levels.simultaneous EEG-fMRI | event-related synchronization | rebound | alpha power | neurovascular-coupling

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Developmental Changes in Task‐Induced Brain Deactivation in Humans Revealed by a Motor Task

Morita

Asada

Naito

2019

Developmental Neurobiology

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Performing tasks activates relevant brain regions in adults while deactivating task‐irrelevant regions. Here, using a well‐controlled motor task, we explored how deactivation is shaped during typical human development and whether deactivation is related to task performance. Healthy right‐handed children (8–11 years), adolescents (12–15 years), and young adults (20–24 years; 20 per group) underwent functional magnetic resonance imaging with their eyes closed while performing a repetitive button‐press task with their right index finger in synchronization with a 1‐Hz sound. Deactivation in the ipsilateral sensorimotor cortex (SM1), bilateral visual and auditory (cross‐modal) areas, and bilateral default mode network (DMN) progressed with development. Specifically, ipsilateral SM1 and lateral occipital deactivation progressed prominently between childhood and adolescence, while medial occipital (including primary visual) and DMN deactivation progressed from adolescence to adulthood. In adults, greater cross‐modal deactivation in the bilateral primary visual cortices was associated with higher button‐press timing accuracy relative to the sound. The region‐specific deactivation progression in a developmental period may underlie the gradual promotion of sensorimotor function segregation required in the task. Task‐induced deactivation might have physiological significance regarding suppressed activity in task‐irrelevant regions. Furthermore, cross‐modal deactivation develops to benefit some aspects of task performance in adults.

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Behavioral correlates of negative BOLD signal changes in the primary somatosensory cortex

Cited by 114 publications

References 42 publications

Negative Blood Oxygen Level Dependence in the Rat:A Model for Investigating the Role of Suppression in Neurovascular Coupling

Negative Blood Oxygen Level Dependence in the Rat:A Model for Investigating the Role of Suppression in Neurovascular Coupling

Poststimulus undershoots in cerebral blood flow and BOLD fMRI responses are modulated by poststimulus neuronal activity

Developmental Changes in Task‐Induced Brain Deactivation in Humans Revealed by a Motor Task

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