Poststimulus undershoots in cerebral blood flow and BOLD fMRI responses are modulated by poststimulus neuronal activity

Mullinger, Karen J.; Mayhew, Stephen D.; Bagshaw, Andrew P.; Bowtell, Richard; Francis, Susan T.

doi:10.1073/pnas.1221287110

Cited by 92 publications

(103 citation statements)

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“…Thus, 15 s periods immediately preceding experience sampling probes were used to demonstrate activation of DMN regions during mind wandering (Christoff et al 2009). Post-stimulus alteration in neural activity is dissociable from stimuli-evoked neural responses (Mullinger et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Neurobiological substrates of cognitive rigidity and autonomic inflexibility in generalized anxiety disorder

Ottaviani

Watson

Meeten

et al. 2016

Biological Psychology

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Neurobiological substrates of cognitive rigidity and autonomic inflexibility in generalized anxiety disorder.Biological Psychology http://dx.doi.org/10. 1016/j.biopsycho.2016.06.009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.  Trait worry was inversely related with prefrontal deactivation to target detection. HRV predicted neural activation changes produced by attentional focus switching. A worry induction increased pre-to post-target deactivation of default mode areas. The induction reduced behavioural and neurobiological differences between groups. AbstractGeneralized anxiety disorder (GAD) is characterized by difficulties in inhibiting both perseverative thoughts (worry and rumination) and autonomic arousal. We investigated the neurobiological substrates of such abnormal inhibitory processes, hypothesizing aberrant functional coupling within 'default mode' (DMN) and autonomic brain networks. Functional imaging and heart rate variability (HRV) data were acquired from GAD patients and controls during performance of three tracking tasks interspersed with a perseverative cognition (PC) induction. After detection of infrequent target stimuli, activity within putative DMN hubs was suppressed, consistent with a redirection of attentional resources from internal to external focus. This magnitude of activity change was attenuated in patients and individuals with higher trait PC, but was predicted by individual differences in HRV. Following the induction of PC in controls, this pattern of neural reactivity became closer to that of GAD patients. Results support, at a neural level, the association between cognitive inflexibility and autonomic rigidity.

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Section: Introductionmentioning

confidence: 99%

Neurobiological substrates of cognitive rigidity and autonomic inflexibility in generalized anxiety disorder

Ottaviani

Watson

Meeten

et al. 2016

Biological Psychology

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“…relationships between the inter-trial variance of BOLD and EEG signals, within single subjects (see e.g. (Mullinger et al, 2013)). This is not (at present) possible with parallel MEG/fMRI experiments where comparisons must be limited to spatial, temporal, cross subject or cross task condition correlation.…”

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confidence: 99%

The relationship between MEG and fMRI

et al. 2014

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In recent years functional neuroimaging techniques such as fMRI, MEG, EEG and PET have provided researchers with a wealth of information on human brain function. However none of these modalities can measure directly either the neuro-electrical or neuro-chemical processes that mediate brain function. This means that metrics directly reflecting brain 'activity' must be inferred from other metrics (e.g. magnetic fields (MEG) or haemodynamics (fMRI)). To overcome this limitation, many studies seek to combine multiple complementary modalities and an excellent example of this is the combination of MEG (which has high temporal resolution) with fMRI (which has high spatial resolution). However, the full potential of multi-modal approaches can only be truly realised in cases where the relationship between metrics is known. In this paper, we explore the relationship between measurements made using fMRI and MEG. We describe the origins of the two signals as well as their relationship to electrophysiology. We review multiple studies that have attempted to characterise the spatial relationship between fMRI and MEG, and we also describe studies that exploit the rich information content of MEG to explore differing relationships between MEG and fMRI across neural oscillatory frequency bands. Monitoring the brain at "rest" has become of significant recent interest to the neuroimaging community and we review recent evidence comparing MEG and fMRI metrics of functional connectivity. A brief discussion of the use of magnetic resonance spectroscopy (MRS) to probe the relationship between MEG/fMRI and neurochemistry is also given. Finally, we highlight future areas of interest and offer some recommendations for the parallel use of fMRI and MEG.

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“…Vascular compliance also contributes to the undershoot (Hua et al, 2011;Zong and Huang, 2011) and may be important in our study since cocaine and amphetamine have known vasoactive properties (Chen et al, 2011;Gottschalk and Kosten, 2002). Recent work also suggests that the undershoot reflects inhibitory neural activity (Mullinger et al, 2013). Thus, the mechanism for the larger undershoot in drug users requires further investigation.…”

Section: Discussionmentioning

confidence: 82%

Temporal profile of fronto-striatal-limbic activity during implicit decisions in drug dependence

Yamamoto

Reynolds

Krmpotich

et al. 2015

Drug and Alcohol Dependence

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Background-Substance dependence is associated with impaired decision-making and altered fronto-striatal-limbic activity. Both greater and lesser brain activity have been reported in drug users compared to controls during decision-making. Inconsistent results might be explained by group differences in the temporal profile of the functional magnetic resonance imaging (fMRI) response. While most previous studies model a canonical hemodynamic response, a finite impulse response (FIR) model measures fMRI signal at discrete time points without assuming a temporal profile. We compared brain activity during decision-making and feedback in substance users and controls using two models: a canonical hemodynamic response function (HRF) and a FIR model. Methods-37 substance-dependent individuals (SDI) and 43 controls performed event-related decision-making during fMRI scanning. Brain activity was compared across group using canonical HRF and FIR models.Results-Compared to controls, SDI were impaired at decision-making. The canonical HRF model showed that SDI had significantly greater fronto-striatal-limbic activity during decisions © 2014 Elsevier Ireland Ltd. All rights reserved.Corresponding author: Jody Tanabe, Department of Radiology, Mail Stop C278, 12700 E 19 th Avenue, Aurora, CO 80045, Office: 303-724-3768, Fax: 303-724-3795, jody.tanabe@ucdenver.edu. Contributors Yamamoto: design, analysis, data interpretation, manuscript; Reynolds: design, analysis, data interpretation, manuscript; Krmpotich: design, analysis, data interpretation, manuscript; Banich: data interpretation, manuscript; Thompson: data interpretation, manuscript; Tanabe: design, analysis, data interpretation, manuscript. All authors contributed to and have approved the final manuscript. Conflict of InterestThe authors report no conflicts of interest.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conclusions-Greater activity in fronto-striatal-limbic pathways in SDI compared to controls is consistent with prior work, further supporting the hypothesis that abnormalities in these circuits underlie impaired decision-making. We demonstrate for the first time using FIR analysis that lower activity during feedback may simply reflect the tail end of the hemodynamic response to decision, the post-stimulus undershoot, rather than an actual difference in feedback response. NIH Public Access

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Poststimulus undershoots in cerebral blood flow and BOLD fMRI responses are modulated by poststimulus neuronal activity

Cited by 92 publications

References 50 publications

Neurobiological substrates of cognitive rigidity and autonomic inflexibility in generalized anxiety disorder

Neurobiological substrates of cognitive rigidity and autonomic inflexibility in generalized anxiety disorder

The relationship between MEG and fMRI

Temporal profile of fronto-striatal-limbic activity during implicit decisions in drug dependence

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