Behavioral changes and gene profile alterations after chronic 1,950‐MHz radiofrequency exposure: An observation in C57BL/6 mice

Jeong, Ye Ji; Son, Yeonghoon; Choi, Hyung Do; Kim, Nam; Lee, Yun Sil; Ko, Young Gyu; Lee, Hae June

doi:10.1002/brb3.1815

Cited by 3 publications

(2 citation statements)

References 29 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All procedures were approved by the Animal Care and Use Committees of Korea Institute of Radiological and Medical Sciences (KIRAMS) Institutional Animal Care and Use Committee (IACUC permit number: KIRAMS2019-0023) and were performed in accordance with the relevant guidelines. We used methods as described previously [ 43 , 44 ] with minor modifications. Briefly, animal exposures were performed in a reverberation chamber with dimensions of 2295 × 2293 × 1470 mm 3 and a one-mode stirrer.…”

Section: Methodsmentioning

confidence: 99%

The Protective Effects of EMF-LTE against DNA Double-Strand Break Damage In Vitro and In Vivo

Jin

Kim

Park

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

With the rapid growth of the wireless communication industry, humans are extensively exposed to electromagnetic fields (EMF) comprised of radiofrequency (RF). The skin is considered the primary target of EMFs given its outermost location. Recent evidence suggests that extremely low frequency (ELF)-EMF can improve the efficacy of DNA repair in human cell-lines. However, the effects of EMF-RF on DNA damage remain unknown. Here, we investigated the impact of EMF-long term evolution (LTE, 1.762 GHz, 8 W/kg) irradiation on DNA double-strand break (DSB) using the murine melanoma cell line B16 and the human keratinocyte cell line HaCaT. EMF-LTE exposure alone did not affect cell viability or induce apoptosis or necrosis. In addition, DNA DSB damage, as determined by the neutral comet assay, was not induced by EMF-LTE irradiation. Of note, EMF-LTE exposure can attenuate the DNA DSB damage induced by physical and chemical DNA damaging agents (such as ionizing radiation (IR, 10 Gy) in HaCaT and B16 cells and bleomycin (BLM, 3 μM) in HaCaT cells and a human melanoma cell line MNT-1), suggesting that EMF-LTE promotes the repair of DNA DSB damage. The protective effect of EMF-LTE against DNA damage was further confirmed by attenuation of the DNA damage marker γ-H2AX after exposure to EMF-LTE in HaCaT and B16 cells. Most importantly, irradiation of EMF-LTE (1.76 GHz, 6 W/kg, 8 h/day) on mice in vivo for 4 weeks reduced the γ-H2AX level in the skin tissue, further supporting the protective effects of EMF-LTE against DNA DSB damage. Furthermore, p53, the master tumor-suppressor gene, was commonly upregulated by EMF-LTE irradiation in B16 and HaCaT cells. This finding suggests that p53 plays a role in the protective effect of EMF-LTE against DNA DSBs. Collectively, these results demonstrated that EMF-LTE might have a protective effect against DNA DSB damage in the skin, although further studies are necessary to understand its impact on human health.

show abstract

Section: Methodsmentioning

confidence: 99%

The Protective Effects of EMF-LTE against DNA Double-Strand Break Damage In Vitro and In Vivo

Jin

Kim

Park

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…A large number of studies have attempted to better understand the effects of a variety of electromagnetic field intensities over variable periods of time on animals [ 134 , 135 , 136 , 137 , 138 , 139 , 140 ], animal tissues [ 141 ], and cells [ 142 , 143 ]. The recent review by Lee et al [ 140 ] provides an excellent summary of much of the animal literature in this regard.…”

Section: Additional Risks Of Space Flight Into Deep Space and Living ...mentioning

confidence: 99%

Homo sapiens—A Species Not Designed for Space Flight: Health Risks in Low Earth Orbit and Beyond, Including Potential Risks When Traveling beyond the Geomagnetic Field of Earth

Hart

2023

Life

View full text Add to dashboard Cite

Homo sapiens and their predecessors evolved in the context of the boundary conditions of Earth, including a 1 g gravity and a geomagnetic field (GMF). These variables, plus others, led to complex organisms that evolved under a defined set of conditions and define how humans will respond to space flight, a circumstance that could not have been anticipated by evolution. Over the past ~60 years, space flight and living in low Earth orbit (LEO) have revealed that astronauts are impacted to varying degrees by such new environments. In addition, it has been noted that astronauts are quite heterogeneous in their response patterns, indicating that such variation is either silent if one remained on Earth, or the heterogeneity unknowingly contributes to disease development during aging or in response to insults. With the planned mission to deep space, humans will now be exposed to further risks from radiation when traveling beyond the influence of the GMF, as well as other potential risks that are associated with the actual loss of the GMF on the astronauts, their microbiomes, and growing food sources. Experimental studies with model systems have revealed that hypogravity conditions can influence a variety biological and physiological systems, and thus the loss of the GMF may have unanticipated consequences to astronauts’ systems, such as those that are electrical in nature (i.e., the cardiovascular system and central neural systems). As astronauts have been shown to be heterogeneous in their responses to LEO, they may require personalized countermeasures, while others may not be good candidates for deep-space missions if effective countermeasures cannot be developed for long-duration missions. This review will discuss several of the physiological and neural systems that are affected and how the emerging variables may influence astronaut health and functioning.

show abstract

Low-dose-rate ionizing radiation affects innate immunity protein IFITM3 in a mouse model of Alzheimer’s disease

Son

Lee

Kim

et al. 2023

International Journal of Radiation Biology

View full text Add to dashboard Cite

Behavioral changes and gene profile alterations after chronic 1,950‐MHz radiofrequency exposure: An observation in C57BL/6 mice

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 3 publications

References 29 publications

The Protective Effects of EMF-LTE against DNA Double-Strand Break Damage In Vitro and In Vivo

The Protective Effects of EMF-LTE against DNA Double-Strand Break Damage In Vitro and In Vivo

Homo sapiens—A Species Not Designed for Space Flight: Health Risks in Low Earth Orbit and Beyond, Including Potential Risks When Traveling beyond the Geomagnetic Field of Earth

Low-dose-rate ionizing radiation affects innate immunity protein IFITM3 in a mouse model of Alzheimer’s disease

Contact Info

Product

Resources

About