Low-dose-rate ionizing radiation affects innate immunity protein IFITM3 in a mouse model of Alzheimer’s disease

Son, Yeonghoon; Lee, Chang Geun; Kim, Joong Sun; Lee, Hae-Jun

doi:10.1080/09553002.2023.2211142

Cited by 7 publications

(4 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LDR also showed a neuroprotective impact in preventing neuronal loss and synaptic degeneration in the hippocampus of 5×familial AD (FAD) mice [46][47][48], as well as in SH-SY5Y neuroblastoma cells exposed to Aβ [46]. Conversely, a recent study using the same animal model (5×FAD mice) indicated that chronic exposure to LDR did not significantly impact memory, locomotion, or amyloid precursor protein (APP) expression, except for a reduction in interferon-γ signaling [35]. In APP/PSEN1 Tg mice, LDR led to a decrease in the number and size of Aβ plaques and an improvement in cognitive function [49].…”

Section: Therapeutic Effects Of Ldr In Admentioning

confidence: 99%

“…Although the exact causes of these diseases remain elusive, they are thought to arise from a complex interplay of genetic factors and environmental influences, with aging as a key contributor. Ionizing radiation, a common tool in medical diagnostics and treatment, has gained attention as a potential therapeutic strategy for neurodegenerative disorders [35]. In particular, LDR presents unique advantages over conventional approaches such as brain exercises.…”

Section: Therapeutic Potential Of Ldr In Neurological Disordersmentioning

confidence: 99%

“…Table 1 (Ref. [28,30,35,[37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55]) presents a detailed summary of research on the therapeutic effects of LDR on different neurological disorders in both clinical and preclinical settings. The initial case report, which described significant improvements in an advanced AD patient receiving hospice care after undergoing five brain computed tomography (CT) scans (each approximately 40 mGy) over a period of three months in 2016, was a critical observation [39].…”

Section: Therapeutic Effects Of Ldr In Admentioning

confidence: 99%

See 2 more Smart Citations

Low-Dose Radiation Therapy for Neurological Disorders: A Double-Edged Sword

Weerasinghe-Mudiyanselage,

Kim,

Kang

et al. 2024

Discovery Medicine

View full text Add to dashboard Cite

Radiation therapy targeting the central nervous system is widely utilized for the management of various brain tumors, significantly prolonging patient survival. Presently, investigations are assessing both clinical and preclinical applications of low-dose radiation (LDR) for the treatment of neuropathological conditions beyond tumor therapy. Special focus is given to refractory neurodegenerative diseases linked to neuroinflammation, such as Alzheimer's and Parkinson's diseases, where LDR has shown promising results. This comprehensive review examines the existing experimental data regarding the utilization of LDR in neurological disorders. It covers potential advantages in reducing neurodegenerative alterations and inflammation, as well as possible adverse effects, including neurological impairments. The review underscores the importance of the exposure protocol and the age at which LDR is administered in the context of the nervous system's pathological and physiological states, as these elements are crucial in determining LDR's therapeutic and toxic outcomes. The article concludes with a discussion on the future directions and challenges in optimizing LDR use, aiming to reduce toxicity while effectively managing neurological disorders.

show abstract

Section: Therapeutic Effects Of Ldr In Admentioning

confidence: 99%

Section: Therapeutic Potential Of Ldr In Neurological Disordersmentioning

confidence: 99%

Section: Therapeutic Effects Of Ldr In Admentioning

confidence: 99%

See 1 more Smart Citation

Low-Dose Radiation Therapy for Neurological Disorders: A Double-Edged Sword

Weerasinghe-Mudiyanselage,

Kim,

Kang

et al. 2024

Discovery Medicine

View full text Add to dashboard Cite

show abstract

“…Previous studies showed that low-dose rate (LDR) irradiation (IR) induces testicular damage ( 9 ) and aggravates nanoparticle-induced lung injury ( 10 ). However, several findings also suggest that low-dose radiation ameliorates asthma symptoms ( 11 ) and delays the progression of Alzheimer's disease ( 12 ). In particular, the relationship between cumulative radiation dose and unfavorable effects, predicated on ongoing, LDR IR exposure, has not been fully explained.…”

Section: Introductionmentioning

confidence: 99%

Possible association of G6PC2 and MUC6 induced by low‑dose‑rate irradiation in mouse intestine with inflammatory bowel disease

Kang,

Bae,

Kang

et al. 2024

Mol Med Rep

View full text Add to dashboard Cite

Although there are several types of radiation exposure, it is debated whether low-dose-rate (LDR) irradiation (IR) affects the body. Since the small intestine is a radiation-sensitive organ, the present study aimed to evaluate how it changes when exposed to LDR IR and identify the genes sensitive to these doses. After undergoing LDR (6.0 mGy/h) γ radiation exposure, intestinal RNA from BALB/c mice was extracted 1 and 24 h later. Mouse whole genome microarrays were used to explore radiation-induced transcriptional alterations. Reverse transcription-quantitative (RT-q) PCR was used to examine time- and dose-dependent radiation responses. The histopathological status of the jejunum in the radiated mouse was not changed by 10 mGy of LDR IR; however, 23 genes were upregulated in response to LDR IR of the jejunum in mice after 1 and 24 h of exposure. Upregulated genes were selected to validate the results of the RNA sequencing analysis for RT-qPCR detection and results showed that only Na + /K + transporting subunit α4, glucose-6-phosphatase catalytic subunit 2 (G6PC2), mucin 6 (MUC6) and transient receptor potential cation channel subfamily V member 6 levels significantly increased after 24 h of LDR IR. Furthermore, G6PC2 and MUC6 were notable genes induced by LDR IR exposure according to protein expression via western blot analysis. The mRNA levels of G6PC2 and MUC6 were significantly elevated within 24 h under three conditions: i) Exposure to LDR IR, ii) repeated exposure to LDR IR and iii) exposure to LDR IR in the presence of inflammatory bowel disease. These results could contribute to an improved understanding of immediate radiation reactions and biomarker development to identify radiation-susceptible individuals before histopathological changes become noticeable. However, further investigation into the specific mechanisms involving G6PC2 and MUC6 is required to accomplish this.

show abstract