Behavioral and Autonomic Effects of Caffeine in Normal
Boys

Rapoport, Judith L.; Elkins, Robert; Neims, Alan; Zahn, Theodore P.; Berg, Chantal van den

doi:10.1159/000457425

Cited by 38 publications

(26 citation statements)

References 8 publications

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“…Other effects in these studies included nervousness, fidgeting, jitteriness, restlessness, hyperactivity, and sleeplessness (123, 187, 188). When children were stratified by prestudy caffeine intake, emotions and behaviors differed between low- and high-dose consumers (187, 188). Children consuming high doses were more easily frustrated and were more nervous during baseline tests than were the children consuming lower doses.…”

Section: Populations At-risk For Harmful Effects Of Caffeinementioning

confidence: 99%

The Safety of Ingested Caffeine: A Comprehensive Review

Temple¹,

Bernard²,

Lipshultz³

et al. 2017

Front. Psychiatry

333

254

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Caffeine is the most widely consumed psychoactive drug in the world. Natural sources of caffeine include coffee, tea, and chocolate. Synthetic caffeine is also added to products to promote arousal, alertness, energy, and elevated mood. Over the past decade, the introduction of new caffeine-containing food products, as well as changes in consumption patterns of the more traditional sources of caffeine, has increased scrutiny by health authorities and regulatory bodies about the overall consumption of caffeine and its potential cumulative effects on behavior and physiology. Of particular concern is the rate of caffeine intake among populations potentially vulnerable to the negative effects of caffeine consumption: pregnant and lactating women, children and adolescents, young adults, and people with underlying heart or other health conditions, such as mental illness. Here, we review the research into the safety and safe doses of ingested caffeine in healthy and in vulnerable populations. We report that, for healthy adults, caffeine consumption is relatively safe, but that for some vulnerable populations, caffeine consumption could be harmful, including impairments in cardiovascular function, sleep, and substance use. We also identified several gaps in the literature on which we based recommendations for the future of caffeine research.

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Section: Populations At-risk For Harmful Effects Of Caffeinementioning

confidence: 99%

The Safety of Ingested Caffeine: A Comprehensive Review

Temple¹,

Bernard²,

Lipshultz³

et al. 2017

Front. Psychiatry

333

254

View full text Add to dashboard Cite

show abstract

“…One study, in which researchers assessed caffeine consumption and features of caffeine dependence in teenagers using a phone screen, showed that 41.7% reported symptoms of tolerance and 77.8% reported symptoms of withdrawal (Bernstein et al, 1994). In addition, adolescents who do not regularly consume caffeine tend to report more negative symptoms when given caffeine than those youth who are habitual consumers (Rapoport et al, 1981a). For example, a study in which adolescents who typically consumed either low or high levels (> 500 mg/day) of caffeine were given caffeine (10 mg/kg/day) or placebo for two weeks, found that parents of low consumers rated them as more restless, fidgety, and having difficulty sleeping when they were given caffeine.…”

Section: 0 Tolerance To the Effects Of Caffeinementioning

confidence: 99%

Caffeine use in children: What we know, what we have left to learn, and why we should worry

Temple

2009

Neuroscience & Biobehavioral Reviews

278

241

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Caffeine is a widely used psychoactive substance in both adults and children that is legal, easy to obtain, and socially acceptable to consume. Although once relatively restricted to use among adults, caffeine-containing drinks are now consumed regularly by children. In addition, some caffeinecontaining beverages are specifically marketed to children as young as four years of age. Unfortunately, our knowledge of the effects of caffeine use on behavior and physiology of children remains understudied and poorly understood. The purpose of this article is to review what is known about caffeine use in children and adolescents, to discuss why children and adolescents may be particularly vulnerable to the negative effects of caffeine, and to propose how caffeine consumption within this population may potentiate the rewarding properties of other substances. The following topics are reviewed: 1) tolerance and addiction to caffeine 2) sensitization and cross-sensitization to the effects of caffeine 3) caffeine self-administration and reinforcing value and 4) conditioning of preferences for caffeine-containing beverages in both adults and children.

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“…The low caffeine consumers did not show an increase in motor activity when given caffeine. The high caffeine consumers had a trend for more speech dysfluencies on placebo (p < 0.1), while low caffeine consumers did not (Rapoport et al 1981a). The high caffeine consumers experienced withdrawal symptoms when given placebo.…”

Section: Children/adolescentsmentioning

confidence: 90%

“…In a third publication from 1981 (Rapoport et al 1981a), the investigators used two different age group; nineteen pre-pubertal boys aged 10.6 years (± 2.5 years) and 20 boys in the late adolescents / young adult men aged 21.7 years (± 3.4 years). They were given a single dose of caffeine 3 mg/kg bw, 10 mg/kg bw or placebo in a double-blind cross-over design, with 48 hours between each treatment period.…”

Section: Children/adolescentsmentioning

confidence: 99%