“…Thus, at hydrostatic physiological pressure (8-10 cm H 2 O), the CSF leakage from the CSF system was not obtained over two hours (Orešković et al, 2001;Orešković et al, 2002), whereas at negative hydrostatic pressure (-10 cm H 2 O) a steady outflow was obtained (about 16 µl/min) over a period of six hours (Orešković et al, 1995). Therefore, hydrostatic pressure is a significant regulatory mechanism in CSF volume control; when CSF pressure is higher than the pressure that exists at the site of collection, this results in CSF escape.…”