Development of hydrocephalus and classical hypothesis of cerebrospinal fluid hydrodynamics: Facts and illusions

Orešković, Darko; Klarica, Marijan

doi:10.1016/j.pneurobio.2011.05.005

Cited by 122 publications

(125 citation statements)

References 161 publications

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“…In addition, according to our hypothesis Bulat and Klarica, 2011;Orešković and Klarica, 2011), CSF is not produced actively and cannot be passively absorbed into the venous sinuses, but freely exchange within the entire CSF system (Fig. 1b).…”

Section: Discussionmentioning

confidence: 89%

“…1b). The hydrodynamic exchange network of widespread blood capillaries within the CNS Bulat and Klarica, 2011;Orešković and Klarica 2011) is ultimately responsible for this.…”

Section: Discussionmentioning

confidence: 99%

“…water) in the CSF system. It has recently been proposed that development of hydrocephalus (Krishnamurthy et al, 2009;Orešković and Klarica, 2011) and the change in CSF volume is caused by changes in blood or CSF osmolarity (Hochwald et al, 1974;Wald et al, 1976;Orešković et al, 2002;Maraković et al, 2010;Jurjević et al, 2012) and that elevated CSF osmolarity should be considered as one of the most important factors in excessive CSF/water accumulation. We have also presumed that the greatest responsibility for the maintenance of CSF iso-osmolarity is the rapid extraction of water from the bloodstream into the osmotically loaded CSF space, and that extracted water would consequently cause an accumulation of fluid, increase in ICP and the development of hydrocephalus.…”

Section: Discussionmentioning

confidence: 99%

“…In light of new hypothesis, the accepted circulation concept regarding hydrocephalus development has also been re-evaluated and a new one has been proposed (Orešković and Klarica, 2011). …”

Section: Introductionmentioning

confidence: 99%

“…The term "compensated hyperosmolarity" represents the time period when CSF hyperosmolarity has already disappeared but the effect of hyperosmolarity still persists in the CSF system. Since we assume that hydrocephalus often develops over a prolonged period (Orešković and Klarica, 2011), and the fact that hydrocephalus was experimentally produced in rats by means of chronic hyperosmolar infusion (Krishnamurthy et al, 2009), the development of hydrocephalus was studied in cats through subchronic micro-volume infusion of hyperosmolar solution into the right lateral ventricle (RLV).…”

Section: Introductionmentioning

confidence: 99%

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“Compensated hyperosmolarity” of cerebrospinal fluid and the development of hydrocephalus

Klarica¹,

Miše²,

Vladić³

et al. 2013

Neuroscience

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Section: Discussionmentioning

confidence: 89%

“…1b). The hydrodynamic exchange network of widespread blood capillaries within the CNS Bulat and Klarica, 2011;Orešković and Klarica 2011) is ultimately responsible for this.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

“Compensated hyperosmolarity” of cerebrospinal fluid and the development of hydrocephalus

Klarica¹,

Miše²,

Vladić³

et al. 2013

Neuroscience

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Maternal exposure to methylmercury causes an impairment in ependymal cilia motility in the third ventricle and dilation of lateral ventricles in mice offspring

Hagiwara

Hagino

Ueda

et al. 2020

Birth Defects Research

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Background: Although maternal MeHg-exposure causes hydrocephalus in the offspring of mice, its pathogenesis has not been fully explained. In the present study, we examined the issue of how maternal MeHg-exposure in mice affects ependymal ciliary movement in the offspring and whether the lateral ventricles in offspring show dilation. Methods: Pregnant mice were given drinking water containing 0, 10, or 20 mg/L MeHg, or a single dose of 2 mg/kg MeHg. Brain slices were prepared from the offspring and the ependymal ciliary movement of ependymal cells in the third ventricle were observed by a high-speed digital camera. The dilation of the lateral ventricles in the offspring was assessed by histological examination. Results: The administration of MeHg in the drinking water of pregnant mice at levels of 10 mg/L and 20 mg/L MeHg from GD10 to birth caused a significant decrease of ciliary beating frequency (CBF) in ependymal cells of the third ventricle in the weaned offspring. The ependymal ciliary movement of the weaned offspring was particularly sensitive in the case of the administration of MeHg at GD10. Moreover, there was a significant dilation of cross-sectional areas of lateral ventricles in weaned offspring from the pregnant mice that had been administered MeHg. The CBF and the cross-sectional areas of the lateral ventricles improved with time. Conclusions: These results suggest that the impairment of ependymal ciliary movement by maternal MeHg-exposure contributes to the development of hydrocephalus in the offspring. K E Y W O R D S brain ventricle, ependymal cilia, hydrocephalus, methylmercury 1 | INTRODUCTION Methylmercury (MeHg), a widespread environmental pollutant, is a powerful neurotoxicant in all animals, including humans. Environmental MeHg bio-accumulates in the food chain and human exposure to MeHg is caused by the dietary intake of MeHg-containing foods, mainly from marine products (National Research Council Committee on the

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Posthemorrhagic hydrocephalus development after germinal matrix hemorrhage: Established mechanisms and proposed pathways

Klebe

McBride

Krafft

et al. 2019

J of Neuroscience Research

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In addition to being the leading cause of morbidity and mortality in premature infants, germinal matrix hemorrhage (GMH) is also the leading cause of acquired infantile hydrocephalus. The pathophysiology of posthemorrhagic hydrocephalus (PHH) development after GMH is complex and vaguely understood, although evidence suggests fibrosis and gliosis in the periventricular and subarachnoid spaces disrupts normal cerebrospinal fluid (CSF) dynamics. Theories explaining general hydrocephalus etiology have substantially evolved from the original bulk flow theory developed by Dr. Dandy over a century ago. Current clinical and experimental evidence supports a new hydrodynamic theory for hydrocephalus development involving redistribution of vascular pulsations and disruption of Starling forces in the brain microcirculation. In this review, we discuss CSF flow dynamics, history and development of theoretical hydrocephalus pathophysiology, and GMH epidemiology and etiology as it relates to PHH development. We highlight known mechanisms and propose new avenues that will further elucidate GMH pathophysiology, specifically related to hydrocephalus.

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Development of hydrocephalus and classical hypothesis of cerebrospinal fluid hydrodynamics: Facts and illusions

Cited by 122 publications

References 161 publications

“Compensated hyperosmolarity” of cerebrospinal fluid and the development of hydrocephalus

“Compensated hyperosmolarity” of cerebrospinal fluid and the development of hydrocephalus

Maternal exposure to methylmercury causes an impairment in ependymal cilia motility in the third ventricle and dilation of lateral ventricles in mice offspring

Posthemorrhagic hydrocephalus development after germinal matrix hemorrhage: Established mechanisms and proposed pathways

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