Behavior of sintered body properties of hydroxyapatite ceramics: effect of uniaxial pressure on green body fabrication

Indra, Ade; Putra, A. B. N. R.; Handra, Nofriady; Fahmi, Hendriwan; Nurzal,; Asfarizal,; Perdana, Mastariyanto; Anrinal,; Subardi, Adi; Affi, Jon; Gunawarman, B.

doi:10.1016/j.mtsust.2021.100100

Cited by 7 publications

(3 citation statements)

References 44 publications

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“…Moreover, the relative density increases by increasing uniaxial pressure between 10 and 40 MPa. At pressures between 40 and 190 MPa, the relative density tends to be constant [ 39 ]. Increased pressure during hot compression resulted in an increased melt flow index (MFI), crystallinity, density, ultimate tensile strength (UTS), and Young’s modulus of the PP-HA biocomposite.…”

Section: Methodsmentioning

confidence: 99%

Characterization of PLA/PCL/Nano-Hydroxyapatite (nHA) Biocomposites Prepared via Cold Isostatic Pressing

et al. 2023

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Hydroxyapatite has the closest chemical composition to human bone. Despite this, the use of nano-hydroxyapatite (nHA) to produce biocomposite scaffolds from a mixture of polylactic acid (PLA) and polycaprolactone (PCL) using cold isostatic pressing has not been studied intensively. In this study, biocomposites were created employing nHA as an osteoconductive filler and a polymeric blend of PLA and PCL as a polymer matrix for prospective usage in the medical field. Cold isostatic pressing and subsequent sintering were used to create composites with different nHA concentrations that ranged from 0 to 30 weight percent. Using physical and mechanical characterization techniques such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and density, porosity, tensile, and flexural standard tests, it was determined how the nHA concentrations affected the biocomposite’s general properties. In this study, the presence of PLA, PCL, and nHA was well identified using FTIR, XRD, and SEM methods. The biocomposites with high nHA content showed intense bands for symmetric stretching and the asymmetric bending vibration of PO43−. The incorporation of nHA into the polymeric blend matrix resulted in a rather irregular structure and the crystallization became more difficult. The addition of nHA improved the density and tensile and flexural strength of the PLA/PCL matrix (0% nHA). However, with increasing nHA content, the PLA/PCL/nHA biocomposites became more porous. In addition, the density, flexural strength, and tensile strength of the PLA/PCL/nHA biocomposites decreased with increasing nHA concentration. The PLA/PCL/nHA biocomposites with 10% nHA had the highest mechanical properties with a density of 1.39 g/cm3, a porosity of 1.93%, a flexural strength of 55.35 MPa, and a tensile strength of 30.68 MPa.

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Section: Methodsmentioning

confidence: 99%

Characterization of PLA/PCL/Nano-Hydroxyapatite (nHA) Biocomposites Prepared via Cold Isostatic Pressing

et al. 2023

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“…The higher green density leads to the higher shrinkage [85]. Second, the lowest shrinkage value occurred at the highest uniaxial pressure because the density between the powders was perfect in the green bodies, so the sintering process did not require high shrinkage to form grain bonds in the sintered bodies [86]. The shrinkage behaviour of HAbased composites is affected by the differential shrinkage behaviour of the various component phases that occurs between the HA and dopant materials [87].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Potential of Barium Zirconate on the Sinterability and Properties of Bovine Hydroxyapatite

Pazarlıoğlu¹

2023

Ceramics - Silikaty

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In the present study, the potential of barium zirconate (BaZrO 3 ; 1-5 wt. %) on the sinterability, and properties of bovine hydroxyapatite (BHA) was evaluated. BHA decomposed into beta and alpha-tricalcium phosphate (β and α-TCP) at a 4.7 % rate. Tetracalcium phosphate (TTCP) was detected as the decomposition phase in the BaZrO 3 added BHAs, and it increased up to 10.7 % with an increasing BaZrO 3 ratio. In addition to TTCP, the phases of BaZrO 3 , Ba 2 ZrO 4 , σ-Ba 2 P 2 O 7 , Ba 3 P 2 O 8 and CaZrO 3 were detected in the composites. The addition of BaZrO 3 at an amount of 3 wt. % has a higher potential than the others to improve the sinterability and properties of BHA. It contributed to the increase in the fracture toughness from 0.99 ± 0.13 to 1.80 ± 0.12 MPa•m 1/2 and the compressive strength from 115. 75 ± 4.27 to 173.66 ± 13.61 MPa, and the decrease in the brittleness index from 4.24 ± 0.31 to 2.45 ± 0.15 µ -1/2 . The in-vitro bioactivity of BHA also increases with the additional BaZrO 3 . However; it is recommended to be used in applications that do not require load bearing in the human body due to its insufficient fracture toughness.

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“…Since CaPO 4 are either thermally unstable (MCPM, MCPA, DCPA, DCPD, OCP, ACP, CDHA) or have a melting point at temperatures exceeding ~1400 • C with a partial decomposition (α-TCP, β-TCP, HA, FA, TTCP), only the first and the second consolidation approaches are used to prepare bulk bioceramics and scaffolds. The methods include uniaxial compaction [154,183,184], isostatic pressing (cold or hot) [87, [185][186][187][188][189][190][191], granulation [192][193][194][195][196][197][198], loose packing [199], slip casting [75,[200][201][202][203][204][205], gel casting [163,[206][207][208][209][210][211], pressure mold forming [212][213][214], injection molding [215][216][217][218], polymer replication [219][220][221][222][223][224]...…”

Section: Forming and Shapingmentioning

confidence: 99%

Calcium Orthophosphate (CaPO4)-Based Bioceramics: Preparation, Properties, and Applications

Dorozhkin¹

2022

Coatings

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Various types of materials have been traditionally used to restore damaged bones. In the late 1960s, a strong interest was raised in studying ceramics as potential bone grafts due to their biomechanical properties. A short time later, such synthetic biomaterials were called bioceramics. Bioceramics can be prepared from diverse inorganic substances, but this review is limited to calcium orthophosphate (CaPO4)-based formulations only, due to its chemical similarity to mammalian bones and teeth. During the past 50 years, there have been a number of important achievements in this field. Namely, after the initial development of bioceramics that was just tolerated in the physiological environment, an emphasis was shifted towards the formulations able to form direct chemical bonds with the adjacent bones. Afterwards, by the structural and compositional controls, it became possible to choose whether the CaPO4-based implants would remain biologically stable once incorporated into the skeletal structure or whether they would be resorbed over time. At the turn of the millennium, a new concept of regenerative bioceramics was developed, and such formulations became an integrated part of the tissue engineering approach. Now, CaPO4-based scaffolds are designed to induce bone formation and vascularization. These scaffolds are usually porous and harbor various biomolecules and/or cells. Therefore, current biomedical applications of CaPO4-based bioceramics include artificial bone grafts, bone augmentations, maxillofacial reconstruction, spinal fusion, and periodontal disease repairs, as well as bone fillers after tumor surgery. Prospective future applications comprise drug delivery and tissue engineering purposes because CaPO4 appear to be promising carriers of growth factors, bioactive peptides, and various types of cells.

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Behavior of sintered body properties of hydroxyapatite ceramics: effect of uniaxial pressure on green body fabrication

Cited by 7 publications

References 44 publications

Characterization of PLA/PCL/Nano-Hydroxyapatite (nHA) Biocomposites Prepared via Cold Isostatic Pressing

Characterization of PLA/PCL/Nano-Hydroxyapatite (nHA) Biocomposites Prepared via Cold Isostatic Pressing

Evaluation of the Potential of Barium Zirconate on the Sinterability and Properties of Bovine Hydroxyapatite

Calcium Orthophosphate (CaPO4)-Based Bioceramics: Preparation, Properties, and Applications

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