Behavior of silica particles introduced into an isolated rat heart as potential drug carriers

Abstract

Silica powders consisting of small spherical particles (50-200 nm) have been obtained by the sol-gel method. A suspension of such particles in the Krebs-Hanseleit solution has been introduced into the coronary circulation of a beating perfused rat heart. The influence of the suspension on the heart muscle and the coronary vessels in the rat body has been histopathologically examined. The particles have not left the lumen of the vessels and have not caused any side effects. These observations suggest the possibility of using such silica particles as a carrier for selected drugs.

Nonporous silica nanoparticles for nanomedicine application

“…Silica NPs emerged as a popular drug delivery system about 10 years later [11]. A wide range of different kinds of payloads, including small-molecule drugs, photosensitizers for photodynamic therapy (PDT), proteins, peptides, DNAs and RNAs, have been incorporated into silica NPs to target diseases such as cancer, heart disease [80, 81], and Parkinson’s disease [82]. Using silica NPs to deliver bioactive molecules can protect them from degradation under physiological conditions, allow for controlled release, prolong their blood circulation, improve disease targeting, and minimize side effects to healthy tissues.…”

Bio‐effect of nanoparticles in the cardiovascular system

“…Targeted drug delivery of Si NPs into the reversibly injured myocardium was explored . Si NPs had been introduced into the coronary circulation of a beating perfused rat heart and did not cause side effects, which indicated the potential use of these NPs as drug carriers for cardiac damage . Galagudza et al investigated the possibility of using Si NPs for passive delivery of adenosine, a prototypical cardioprotective agent, into ischemic‐reperfused heart tissue.…”

“…147 Si NPs had been introduced into the coronary circulation of a beating perfused rat heart and did not cause side effects, which indicated the potential use of these NPs as drug carriers for cardiac damage. 148 Galagudza et al 149 investigated the possibility of using Si NPs for passive delivery of adenosine, a prototypical cardioprotective agent, into ischemic-reperfused heart tissue. The results showed that the adenosine-mediated infarct size was increased, and the hypotensive effect of adenosine was attenuated due to the immobilization of adenosine on Si NPs in the rat.…”

Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO2 Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque

“…Small silica particles in an isolated rat heart model were successfully delivered to coronary circulation and were shown to have no harmful effects on the heart muscle. [17]. Another study showed that the porous silica matrix successfully delivers photosensitizer to smooth muscle cells and enables PDT (phototoxic reaction) [18].…”