Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO2 Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque

Gerasymchuk, Yuriy; Kałas, Wojciech; Arkowski, Jacek; Marciniak, Ł.; Hreniak, D.; Wysokińska, Edyta; Strządała, Leon; Obremska, Marta; Chernii, Viktor; Stręk, W.

doi:10.3390/molecules26020260

Cited by 5 publications

(8 citation statements)

References 30 publications

(52 reference statements)

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“…The emission intensity was significantly lower in the case of composites; nevertheless, it was easily registered, although the PcZr concentration was quite low. The emission intensity of photosensitizers strongly corresponds to the ROS generation and, as a result, to their biological activity (Gerasymchuk et al 2021;Nyokong and Antunes 2013). Therefore, due to the observed photoluminescence, the photoactivity and ROS generation under red/NIR light exposition was expected and demonstrated for all the samples.…”

Section: Photoluminescent Propertiesmentioning

confidence: 80%

“…6, 7, 8, 9) (Gerasymchuk et al 2004;Tretyakova et al 2007). As has been shown in our earlier work, the use of saline instead of distilled water reduces aggregation of axially substituted zirconium phthalocyanine complexes (Gerasymchuk et al 2021) and also makes it possible to evaluate photoactivity under conditions similar to biological conditions. In the case of the PcZr(APhA) complex, agglomeration processes were observed not only for the water environment, but also in a DMSO solution (Fig.…”

Section: Uv-vis-nir Absorbance Measurementsmentioning

confidence: 84%

“…(1) Graphite oxide-a nanosized carrier and catalyst of silver nanoparticles (Ag-NPs) formation, which shows antibacterial properties and enhances the antimicrobial activity of silver (Gerasymchuk et al 2017;Lukowiak et al 2019;Tahershamsi et al 2020;Kędziora et al 2013;Saladino et al 2020); (2) Ag-NPs-the antibacterial activity of silver is well known, but when the silver is in the form of nanoparticles, this action is more efficient due to an increased contact area further magnified by the GO presence (Kędziora et al 2013;Kędziora et al 2020); (3) Zirconium(IV) phthalocyanine complex (ZrPc) with axial ligands-macrocyclic water soluble metal complex (dye) which plays a role of a photosensitizer and generates singlet oxygen upon light irradiation (Tomachinski et al 2003;Tomachynski et al 2004;Gerasymchuk et al 2021).…”

Section: Introductionmentioning

confidence: 99%

“…The preliminary results showed that bis(lysinato)ZrPc have blocked growth and/or proliferation of cancer cells which was enhanced by irradiation and can also demonstrate a cytostatic effect against highly resistant pathogenic bacteria. That's why we expected that new ZrPc complexes will have bacterial growth-inhibitory activity and germicidal effect also against pathogenic bacteria obtained from infected root canals, and may find application in dentistry (Tomachynski et al 2004;Gerasymchuk et al 2021). As previous studies have shown, the antibacterial effect depends directly on the ability of phthalocyanine complexes (as well as composite material) to generate reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

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Composites based on graphite oxide and zirconium phthalocyanines with aromatic amino acids as photoactive materials

et al. 2021

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This article is a part of a scientific project focused on obtaining a new type of composite materials that are characterized by singlet oxygen generation upon irradiation with red light, which can be used as antibacterial agents. The composite material is nanoscale graphite oxide (GO) particles covalently bonded to an axially substituted zirconium phthalocyanine complex. For this purpose, two phthalocyanine zirconium complexes, axially mono-substituted with 4-aminosalicylic or 4-aminophthalic acids, were prepared and measured in terms of structure, morphology, and spectroscopic properties. The zirconium phthalocyanines are photosensitizers, and the axial ligands are bridging links connecting the complexes to the GO carrier (due to their terminal amino groups and carboxyl groups, respectively). The axial ligand in zirconium phthalocyanine complexes has a strong influence on the stability and optical properties of composite materials and, consequently, on reactive oxygen species (ROS) generation. In this paper, the effect of composite components (4-aminophthalato or 4-aminosalicylato substituted zirconium phthalocyanine complex as a photosensitizer and graphite oxide as a carrier and modulator of the action of active components) on ROS generation for potential antibacterial use is discussed.

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Section: Photoluminescent Propertiesmentioning

confidence: 80%

Section: Uv-vis-nir Absorbance Measurementsmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Composites based on graphite oxide and zirconium phthalocyanines with aromatic amino acids as photoactive materials

et al. 2021

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“…Watersoluble complexes with citrate, lysinate, sulfosalicylate and other ligands show high cytostatic and cytoto xic activity and can be proposed as agents for the photodynamic and dark therapy of malignant neoplasms [59,60]. The complexes containing a free amino or carboxy group in extraplanar ligands show high antimicrobial activity in the composite cement with graphite oxide used in dentistry [61,62]. Zr and Hf phthalocyanines with extraplanar ligands can inhibit or redirect the fibril formation of proteins associated with neurodegenerative diseases [63][64][65][66][67].…”

Section: Inorganic Chemistrymentioning

confidence: 99%

Out-of-Plane Coordinated Zirconium(iv) and Hafnium(iv) Phthalocyaninates

Chernii¹,

Tretyakova²,

Tomachynska³

et al. 2021

Ukr. Chem. Journ.

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The article is devoted to methods of synthesis, the structure, and spectral characteristics of zirconium and hafnium phthalocyaninates with out-of-plane coordinated ligands. The general scheme for the synthesis of out-of-plane coordinated Zr and Hf phthalocyanines includes obtaining initial dichloride or dihydroxo complexes, which then undergo substitution reactions with -dicarbonyl compounds, hydroxybenzoic, sulfo- and aliphatic carboxylic acids, etc. In the case of polyphenols, which are bidentate ligands, one ligand is coordinated to the central atom of the macrocycle. If -dicarbonyl compounds or carboxylic acids are introduced into the reaction, two ligands are coordinated. The reactivity of the out-of-plane coordinated ligands of Zr and Hf phthalocyanines was also investigated. In all obtained out-of-plane coordinated Zr and Hf phthalocyanines, the ligands are located in the cis position relative to the plane of the phthalocyanine macrocycle. X-ray diffraction, NMR, and UV-Vis spectroscopy have proved this arrangement of ligands. According to the X-ray diffraction data of Zr and Hf dibenzoylmethanato phthalocyanines, the metal atom is out of the plane of the phthalocyanine macrocycle, which itself is not planar. The central atoms are located almost in the middle between the N4 planes of the phthalocyanine macrocycle and the O4 of the extraplanar ligands. The UV-Vis spectra of out-of-plane coordinated Zr and Hf phthalocyanines in organic solvents have a typical appearance for most metal phthalocyanines, characterized by a B-band of absorption in the region of 335–350 nm, a Q-band at 680-690 nm, and its satellite in the region of 615–620 nm. If the extraplanar ligand is a chromophore (e.g., curcumin or condensed derivatives of dehydroacetic acid), there are additional absorption bands in UV-Vis spectra located between the B- and Q-bands. The influence of the nature of the central metal atoms, ligands and solvents on the fluorescent properties of the out-of-plane coordinated Zr and Hf phthalocyanines was also discussed.

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Application of Photodynamic Therapy in Cardiology

Wańczura,

Aebisher,

Kłosowicz

et al. 2024

IJMS

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The origins of photodynamic therapy (PDT) date back to 1904. Since then, the amount of research proving PDT and, consequently, its applicability to various disease states has steadily increased. Currently, PDT is mainly used in oncology to destroy cancer cells. It is being worked on for possible use in other medical fields as well, including cardiology. It can be used in the prevention of restenosis, often occurring after vascular surgical interventions, for destroying atherosclerotic plaques and as a new ablative method of ectopic centers in the treatment of atrial fibrillation. The purpose of this review is to summarize the knowledge to date regarding the therapeutic potential of using PDT for various pathological conditions in cardiology. The review also focuses on the current limitations associated with the use of PDT and identifies areas where more research is needed to develop better drug regimens. Materials and methods: The study analyzed 189 medical articles. The articles came from PubMed, Frontiers, Google Scholar, Science Direct and Web of Science databases. Through the excitation of light, a photosensitizer (PS) introduced into the body, the destruction of pathological cells occurs. PTD is widely used in oncology of the central nervous system (CNS). This process is made possible by the production of free oxygen radicals (ROS) and singlet oxygen, which generate oxidative stress that destroys sensitive cancer cells. In recent years, photosensitizers have also been discovered to have a strong affinity for macrophages that fill atherosclerotic plaques, making these compounds suitable for treating atherosclerosis. By inducing apoptosis of smooth muscle cells, inactivating basic fibroblast growth factor (FGF-β) and inhibiting endothelial cell hyperplasia, PDT can be used to prevent restenosis after surgical proceduresPDT appears to be a minimally invasive and highly effective therapeutic method, especially when combined with other therapeutic methods. Unfortunately, the small number of animal model studies and human clinical trials greatly limit the applicability of PDT on a wider scale. Current limitations, such as the depth of penetration, delivery of photosensitizer particles to the direct site of the lesion or the appropriate choice of photosensitizer in relation to the nature of the pathology, unfortunately make it impossible to replace current therapeutic approaches.

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Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO2 Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque

Cited by 5 publications

References 30 publications

Composites based on graphite oxide and zirconium phthalocyanines with aromatic amino acids as photoactive materials

Composites based on graphite oxide and zirconium phthalocyanines with aromatic amino acids as photoactive materials

Out-of-Plane Coordinated Zirconium(iv) and Hafnium(iv) Phthalocyaninates

Application of Photodynamic Therapy in Cardiology

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