Behavior of rifampicin in association with ?-cyclodextrin in aqueous media: a spectroscopic and conductometric study

Mehta, Shalina; Bhasin, K. K.; Mehta, Neena; Dham, Shilpee

doi:10.1007/s00396-004-1181-5

Cited by 14 publications

(10 citation statements)

References 17 publications

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“…In a previous study from our research lab [20], UV-vis spectrum of the aqueous solution of DS was recorded at different drug concentrations at room temperature. Molar absorption coefficient ε, at λ max = 275 nm was estimated to be 8221.14 ± 80 M −1 cm −1 .…”

Section: Uv-visible Measurementsmentioning

confidence: 99%

“…Keeping this in mind, it was planned to investigate the behavior of diclofenac sodium in the presence of different cyclodextrins via spectroscopic and conductivity techniques. The information obtained from conductivity studies have been correlated with the observations of spectroscopic studies [15][16][17][19][20][21]. The analysis of the results will provide an insight into the thermodynamics of DS:CD association.…”

Section: Introductionmentioning

confidence: 96%

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Energetically favorable interactions between diclofenac sodium and cyclodextrin molecules in aqueous media

Mehta

Bhasin

Dham

2008

Journal of Colloid and Interface Science

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Section: Uv-visible Measurementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Energetically favorable interactions between diclofenac sodium and cyclodextrin molecules in aqueous media

Mehta

Bhasin

Dham

2008

Journal of Colloid and Interface Science

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“…The 1 H and 15 N NMR analysis of free and complexed RIF revealed important changes in piperazine ring peaks of the drug, suggesting the interaction of this region with the hydrophobic core of HPβCD. Furthermore, UV analysis indicated an absence of strong bonding between the drug and the carrier [104].…”

Section: Cyclodextrin Inclusion Complexesmentioning

confidence: 99%

Present status of nanoparticle research for treatment of Tuberculosis

2011

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-Nanotechnology has offered enormous improvement in field of therapeutics by means of designing of drug delivery systems and opened the possibility of controlling infections at the molecular level. Nanocarriers can cross biological barriers and are able to target cellular reservoirs of Mycobacterium tuberculosis (M. tuberculosis). Nanoparticle-based systems have significant potential for treatment and prevention of tuberculosis (TB). A variety of nanocarriers have been widely evaluated as potential drug delivery systems for various administration routes. Targeting the drugs to certain physiological sites such as the lymph nodes has emerged as a promising strategy in treating TB with improved drug bioavailability and reduction of the dosing frequency. Nanotechnology based rational targeting may improve therapeutic success by limiting adverse drug effects and requiring less frequent administration regimes, ultimately resulting in more patients compliance and thus attain higher adherence levels. The development of nanoparticle based aerosol vaccine is undergoing which could serve as new platform for immunization. Present article compiles the general physiological aspects of the infection along with new research uptades on nanocarriers used in prevention of tuberculosis. _______________________________________________________________________________________

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“…[13,14] In order to improve the bioavailability of RIF and the other tuberculostatic drugs, several research groups have been developing drug delivery systems (DDS). [12] Suggested formulations involve hydrosoluble polymers, [15][16][17][18][19] solid dispersions, [20] microparticles, [9] liposomes, [21,22] inclusion complexes [23,24] and dendrimers [25]. Ideally, a DDS would transport the active compounds to their targets, reducing the therapeutic dosage while keeping the desired drug level for a long period of time, minimizing adverse effects and simplifying the treatment.…”

Section: Introductionmentioning

confidence: 99%

Association of the anti-tuberculosis drug rifampicin with a PAMAM dendrimer

Bellini

Guimarães

Pacheco

et al. 2015

Journal of Molecular Graphics and Modelling

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The association of the anti-tuberculosis drug rifampicin (RIF) with a 4th-generation poly(amidoamine) (G4-PAMAM) dendrimer was investigated by means of molecular dynamics simulations. The RIF load capacity was estimated to be around 20 RIF per G4-PAMAM at neutral pH. The complex formed by 20 RIF molecules and the dendrimer (RIF20-PAMAM) was subjected to 100 ns molecular dynamics (MD) simulations at two different pH conditions (neutral and acidic). The complex was found to be significantly more stable in the simulation at neutral pH compared to the simulation at low pH in which the RIF molecules were rapidly and almost simultaneously expelled to the solvent bulk. The high stability of the RIF-PAMAM complex under physiological pH and the rapid release of RIF molecules under acidic medium provide an interesting switch for drug targeting since the Mycobacterium resides within acidic domains of the macrophage. Altogether, these results suggest that, at least in terms of stability and pH-dependent release, PAMAM-like dendrimers may be considered suitable drug delivery systems for RIF and derivatives.

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Behavior of rifampicin in association with ?-cyclodextrin in aqueous media: a spectroscopic and conductometric study

Cited by 14 publications

References 17 publications

Energetically favorable interactions between diclofenac sodium and cyclodextrin molecules in aqueous media

Energetically favorable interactions between diclofenac sodium and cyclodextrin molecules in aqueous media

Present status of nanoparticle research for treatment of Tuberculosis

Association of the anti-tuberculosis drug rifampicin with a PAMAM dendrimer

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