“…The MWT is the most popular behavioral assay of place navigation memory in rodents. While many dorsal–ventral functional differences in hippocampal lesion studies have been reported in the MWT (Ferbinteanu & McDonald, , ; McDonald et al, ; Moser et al, , ; Ruediger et al, ), differences in cellular activation were found during random spatial sampling and navigation in dry‐land tasks (Chawla et al, ). Here, we sought to determine if dorsal–ventral activation differs in CA1 during place navigation in the MWT by measuring nuclear Arc mRNA expression, which has previously been found to increase following spatial navigation (Guzowski, Setlow, Wagner, & McGaugh, ), and whether changes to goal location or spatial context affect cellular activation probability as previously suggested (Bye & McDonald, ; Vann et al, ).…”