“…Gene expression of the receptors for ghrelin, insulin, and leptin, which like GLP-1 are other feeding-relevant hormones previously shown to be important in hippocampal function (Suarez et al, 2019), was markedly lower than Glp1r expression and not enriched in MCs ( Figure 1b ). HippoSeq did not divide MCs into dorsal and ventral DG MCs, which is important because dorsal and ventral MCs differ not only molecularly (Blasco-Ibanez & Freund, 1997; Fujise, Liu, Hori, & Kosaka, 1998), physiologically (Bui et al, 2018; Fredes et al, 2021; Jinno, Ishizuka, & Kosaka, 2003), and anatomically (Botterill, Gerencer, Vinod, Alcantara-Gonzalez, & Scharfman, 2021; Houser, Peng, Wei, Huang, & Mody, 2020), but also in their role in cognitive function (Bauer et al, 2021; Botterill, Vinod, et al, 2021; Yassa & Stark, 2011). Therefore, to corroborate RNA-seq data and examine potential dorsal and ventral MC expression differences, we examined in situ hybridization (ISH) data for Glp1r from the Allen Mouse Brain Atlas (Lein et al, 2007) ( Figure 1c,d ).…”