Behavior and toxicity assessment of copper nanoparticles in aquatic environment: A case study on red swamp crayfish

Yang, Li; He, Zhen; Li, Xiaohua; Jiang, Zhe; Xuan, Fujun; Tang, Boping; Xin-min, Bian

doi:10.1016/j.jenvman.2022.114986

Cited by 15 publications

(3 citation statements)

References 48 publications

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“…Zebrafish larvae exposed to AgNPs similarly showed a notable increase in Ag concentration after 21 days of exposure [ 20 ]. Likewise, exposure to CuNPs and CuSO 4 caused a remarkable increase in Cu bioaccumulation in various tissues of red swamp crayfish ( Procambarus clarkii ) [ 21 ] and barnacle larvae ( Balanus amphitrite ) [ 22 ]. Compared to the control without Cu exposure, Cu bioaccumulation in barnacle larvae exposed to 200 µg/L CuNPs (particle size: 20 nm) increased by 5.3–12.6 times [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…Sixty larvae were collected from each treatment and homogenized with an ultrasonic cell crusher (JY98-IIIN, SCIENTZ, Ningbo, China) under ice-cold conditions, with the addition of Tris-HCl buffer ( w / v , 1:9, pH 7.4, 0.01 mol/L, containing 0.01 mol/L of sucrose, 0.0001 mol/L of EDTA-2Na, and 0.8% of NaCl) [ 21 ]. The homogenates were then centrifuged, and the resulting supernatant was collected to measure the oxidative stress parameters.…”

Section: Methodsmentioning

confidence: 99%

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Copper-Nanoparticle-Induced Neurotoxic Effect and Oxidative Stress in the Early Developmental Stage of Zebrafish (Danio rerio)

Liu,

Tong,

et al. 2024

Molecules

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Copper nanoparticles (CuNPs) are extensively used in electronics, cosmetics, fungicides, and various other fields due to their distinctive qualities. However, this widespread usage can contribute to environmental contamination and heightened health risks for living organisms. Despite their prevalent use, the ecological impacts and biosafety of CuNPs remain inadequately understood. The present study aims to delve into the potential toxic effects of CuNPs on zebrafish (Danio rerio) embryos, focusing on multiple indexes such as embryonic development, neurotoxicity, oxidative stress, and inflammatory response. The results revealed a notable increase in the death rate and deformity rate, alongside varying degrees of decrease in hatching rate and heart rate following CuNPs exposure. Particularly, the frequency of spontaneous tail coiling significantly declined under exposure to CuNPs at concentrations of 500 µg/L. Furthermore, CuNPs exposure induced alterations in the transcriptional expression of GABA signaling pathway-related genes (gabra1, gad, abat, and gat1), indicating potential impacts on GABA synthesis, release, catabolism, recovery, and receptor binding. Additionally, CuNPs triggered oxidative stress, evidenced by disruption in superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities, along with elevated malondialdehyde (MDA) levels. This oxidative stress subsequently led to a proinflammatory cascade, as demonstrated by the increased transcriptional expression of inflammatory markers (il-1β, tnf-α, il-6, and il-8). Comparative analysis with copper ion (provided as CuCl2) exposure highlighted more significant changes in most indexes with CuCl2, indicating greater toxicity compared to CuNPs at equivalent concentrations. In conclusion, these findings provide valuable insights into the toxic effects of CuNPs on zebrafish embryo development and neurotransmitter conduction. Furthermore, they present technical methodologies for assessing environmental and health risks associated with CuNPs, contributing to a better understanding of their biosafety and ecological impact.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Copper-Nanoparticle-Induced Neurotoxic Effect and Oxidative Stress in the Early Developmental Stage of Zebrafish (Danio rerio)

Liu,

Tong,

et al. 2024

Molecules

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show abstract

“…290 Moreover, model simulation is also crucial, utilizing environmental toxicology and chemodynamics models to predict the migration, transformation, and accumulation patterns of MNPs in the environment and within organisms. 291…”

Section: Challenges and Prospectsmentioning

confidence: 99%