Beetroot juice protects against N-nitrosodiethylamine-induced liver injury in rats

Krajka‐Kuźniak, Violetta; Szaefer, Hanna; Ignatowicz, Ewa; Adamska, Teresa; Baer‐Dubowska, Wanda

doi:10.1016/j.fct.2012.03.062

Cited by 61 publications

(54 citation statements)

References 43 publications

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“…In the study of Szaefer et al , beetroot juice treatment increased GST levels in mammary glands and induced GST activity in the hepatic cells of female Sprague‐Dawley rats treated with 7,12‐dimethylbenz[ α ]anthracene (DMBA). Betalains from beetroot juice also exhibited a protective role in N ‐nitrosodiethylamine‐induced liver injury in Wistar rats through phase II enzyme induction …”

Section: Resultsmentioning

confidence: 99%

Health‐promoting bioactivities of betalains from red dragon fruit (Hylocereus polyrhizus (Weber) Britton and Rose) peels as affected by carbohydrate encapsulation

et al. 2016

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Section: Resultsmentioning

confidence: 99%

Health‐promoting bioactivities of betalains from red dragon fruit (Hylocereus polyrhizus (Weber) Britton and Rose) peels as affected by carbohydrate encapsulation

et al. 2016

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“…Decreased protein synthesis, cellular necrosis and corrosion of liver parenchyma in severely fibrotic rats appear to be the most obvious causes of the weight loss and the changes observed in liver function markers (Chattopadhyay et al, 2012;Chowdhury & Taylor, 1998;Krajka-Kuzniak et al, 2012;Lee et al, 2009;Wang et al, 2012). Significantly increased HP (liver/sera) levels have been demonstrated in patients with various liver pathologies (Mata et al, 1975;Yamada & Hirayama, 1983).…”

Section: Discussionmentioning

confidence: 99%

“…Under laboratory conditions, a number of chemical compounds such as CCl 4 , thioacetamide and N 0 -nitrosodiethylamine (NDEA) induce hepatic fibrosis (Bruck et al, 2001;Eidi et al, 2013;George et al, 2001;Krajka-Kuzniak et al, 2012). However, N 0 -nitrosodimethylamine (NDMA) has the advantage of inducing fibrosis within shortest duration of 21 days, with lesser animal mortality and better reproducibility (George & Chandrakasan, 1996).…”

Section: Introductionmentioning

confidence: 99%

“…However, N 0 -nitrosodimethylamine (NDMA) has the advantage of inducing fibrosis within shortest duration of 21 days, with lesser animal mortality and better reproducibility (George & Chandrakasan, 1996). Induction of hepatic fibrosis and tumorigenesis in rats by NDMA occur via the activation of CYP 450 enzymes (George et al, 2001;Kasprzyk-Hordern et al, 2005), which adversely affects biochemical and molecular parameters defining liver function (Ahmad et al, 2009;George & Chandrakasan, 2000;Krajka-Kuzniak et al, 2012). Changes in fibrotic liver also include modulation in functions or levels of vitamins, which are important participants during recovery of liver from diseased conditions (Chattopadhyay et al, 2012;Chung et al, 2010;Himmerich et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Vitamin B₁₂supplement alleviatesN′-nitrosodimethylamine-induced hepatic fibrosis in rats

Ahmad

Afroz

Gupta

et al. 2014

Pharmaceutical Biology

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Context: Altered vitamin B 12 levels have been correlated with hepatotoxicity; however, further evidence is required to establish its protective role. Objective: To evaluate the effects of vitamin B 12 supplement in protecting N 0 -nitrosodimethylamine (NDMA)-induced hepatic fibrosis in Wistar rats. Materials and methods: Hepatic fibrosis was induced by administering NDMA in doses of 10 mg/kg body weight thrice a week for 21 days. Another group received equal doses (10 mg/kg body weight) of vitamin B 12 subsequent to NDMA treatment. Animals from either group were sacrificed weekly from the start of the treatment along with their respective controls. Progression of hepatic fibrosis, in addition to the effect of vitamin B 12 , was assessed biochemically for liver function biomarkers, liver glycogen, hydroxyproline (HP) and B 12 reserves along with histopathologically by hematoxylin and eosin (H & E) as well immunohistochemical staining for a-SMA expression. Results and discussion: Elevation in the levels of aminotransferases, SALP, total bilirubin and HP was observed in NDMA treated rats, which was concomitant with remarkable depletion in liver glycogen and B 12 reserves (p50.05). Liver biopsies also demonstrated disrupted lobular architecture, collagen amassing and intense fibrosis by NDMA treatment. Immunohistochemical staining showed the presence of activated stellate cells that was dramatically increased up to day 21 in fibrotic rats. Following vitamin B 12 treatment, liver function biomarkers, glycogen contents and hepatic vitamin B 12 reserves were restored in fibrotic rats, significantly. Vitamin B 12 administration also facilitated restoration of normal liver architecture. Conclusion: These findings provide interesting new evidence in favor of protective role for vitamin B 12 against NDMA-induced hepatic fibrosis in rats.

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“…Recently, the interest for red beet and radish has arisen because of medical benefits of their principal components anthocyanins and glucosinolates (Krajka-Kuźniak et al 2012, Gao et al 2014. In terms of acreage, production or consumption, red beet and radish are not the world's major vegetables but they occupy unique niches in Europe, parts of Asia and North America (Goldman and Navazio 2008).…”

Section: Manuscript Received April 2014mentioning

confidence: 99%

Intercropped red beet and radish with green bean affected microbial communities and nodulation by indigenous rhizobia

Ugrinović¹,

Mijatovic²,

Zdravković³

et al. 2014

AFSci

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The impact of intercropping green bean (Phaseolus vulgaris L.) with red beet (Beta vulgaris L. var. rubra) and radish (Raphanus sativus L.), two non-legume plants, on the plants' yields, as well as the effect on occurrence and enumeration of microorganisms in the rhizosphere was studied. The intercrop efficacy evaluation, using Land equivalent ratio, revealed values above 1.0 for all intercropped treatments. Diversity of rhizobia from green bean nodules under different intercropping and fertilizing conditions was observed. On the basis of morphological and biochemical characteristics, 67 out of 158 isolates from green bean roots were selected as rhizobia (42.4%), confirmed by detection of 780 bp nifH gene fragments in nifH-PCR, and then clustered in 27 phenotype patterns. Production of exopolysaccharide succinoglycan was observed in 23 rhizobial isolates, while 6 were detected to solubilize tricalcium phosphate. Screening of genetic diversity using (GTG) 5 -PCR fingerprinting showed presence of six different patterns on the 92% similarity level.

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Beetroot juice protects against N-nitrosodiethylamine-induced liver injury in rats

Cited by 61 publications

References 43 publications

Health‐promoting bioactivities of betalains from red dragon fruit (Hylocereus polyrhizus (Weber) Britton and Rose) peels as affected by carbohydrate encapsulation

Health‐promoting bioactivities of betalains from red dragon fruit (Hylocereus polyrhizus (Weber) Britton and Rose) peels as affected by carbohydrate encapsulation

Vitamin B₁₂supplement alleviatesN′-nitrosodimethylamine-induced hepatic fibrosis in rats

Intercropped red beet and radish with green bean affected microbial communities and nodulation by indigenous rhizobia

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Beetroot juice protects against N-nitrosodiethylamine-induced liver injury in rats

Cited by 61 publications

References 43 publications

Health‐promoting bioactivities of betalains from red dragon fruit (Hylocereus polyrhizus (Weber) Britton and Rose) peels as affected by carbohydrate encapsulation

Health‐promoting bioactivities of betalains from red dragon fruit (Hylocereus polyrhizus (Weber) Britton and Rose) peels as affected by carbohydrate encapsulation

Vitamin B12supplement alleviatesN′-nitrosodimethylamine-induced hepatic fibrosis in rats

Intercropped red beet and radish with green bean affected microbial communities and nodulation by indigenous rhizobia

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Vitamin B₁₂supplement alleviatesN′-nitrosodimethylamine-induced hepatic fibrosis in rats