Health‐promoting bioactivities of betalains from red dragon fruit (<i>Hylocereus polyrhizus</i> (Weber) Britton and Rose) peels as affected by carbohydrate encapsulation

Rodriguez, Evelyn B.; Vidallon, Mark Louis P.; Mendoza, David Joram; Reyes, Charisse T.

doi:10.1002/jsfa.7681

Cited by 59 publications

(26 citation statements)

References 50 publications

(57 reference statements)

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“…However, to corroborate the first hypothesis, a positive correlation between betaxanthins and antiangiogenic activity (r > 0.5176) as well as with the haemoglobin content (r > 0.4475) was also found. Some studies have shown previously the dose-dependent anti-angiogenic properties of betalains (Ninfali, Antonini, Frati, & Scarpa, 2017;Rodriguez et al, 2016). The angiogenesis inhibition seems due to their ability to scavenge the reactive oxygen species and to induce apoptosis on CD31+ microvessel endothelial cells (Zhang, Pan, Wang, Lubet, & You, 2013).…”

Section: Discussionmentioning

confidence: 98%

“…The angiogenesis inhibition seems due to their ability to scavenge the reactive oxygen species and to induce apoptosis on CD31+ microvessel endothelial cells (Zhang, Pan, Wang, Lubet, & You, 2013). In fact, reactive oxygen and nitrogen species are inflammatory and angiogenesis modulators able to influence vessel formation (Rodriguez et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

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Opuntia ficus‐indica (L.) Mill. fruit as source of betalains with antioxidant, cytoprotective, and anti‐angiogenic properties

Smeriglio

Bonasera

Germanò

et al. 2019

Phytotherapy Research

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The aim of this work was to investigate the phytochemical profile and biological properties of different colours of betalain cactus pear extracts, evaluating their antioxidant, cytoprotective, and anti‐angiogenic properties by cell‐free, cell‐based, and in vivo assays. A QuEChERS extraction method followed by RP‐LC‐DAD‐MS/MS analysis showed that indicaxanthin and betanin were the main compounds (≥94.32% and ≥96.95%, respectively). Orange cactus pear extracts exert the best antioxidant activity in all assays carried out, in particular into ORAC (17,352.55 ± 987.407 mg trolox equivalents/100 g dry weight) and β‐carotene bleaching (60.35%) assays. The red ones, instead, showed the best cytoprotective activity decreasing the cell mortality, LDH, and Caspase‐3 release ranging from 4.0 to 55%. According to antioxidant results, the orange cactus pear extracts showing also the highest anti‐angiogenic activity (IC50 19.31 μg/ml), followed by the red (IC50 23.55 μg/ml) and the yellow ones (IC50 33.97 μg/ml). In light of the results and correlation analysis, the behaviour of these molecules varies a lot according to their structure and physicochemical features and synergistic activity between betalain classes may be postulated; so the plant complex could be of greater interest compared with the isolated molecules for potential nutraceutical and pharmaceutical uses.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Opuntia ficus‐indica (L.) Mill. fruit as source of betalains with antioxidant, cytoprotective, and anti‐angiogenic properties

Smeriglio

Bonasera

Germanò

et al. 2019

Phytotherapy Research

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“…Basic medical research has revealed that betalain‐rich extracts possess anti‐inflammatory and anticancer properties (Kapadia et al ., ; Lechner et al ., ; Martinez et al ., ; Rodriguez et al ., ). Although more than 50 molecular species of betalains have been reported (Delgado‐Vargas et al ., ), very few exhibit biological activity.…”

Section: Introductionmentioning

confidence: 97%

“…The horizontal axis indicates the retention time (min), whereas the vertical axis indicates the signal intensity (lV). Rodriguez et al, 2016). Although more than 50 molecular species of betalains have been reported (Delgado-Vargas et al, 2000), very few exhibit biological activity.…”

Section: Introductionmentioning

confidence: 99%

Isolation of amaranthin synthetase from Chenopodium quinoa and construction of an amaranthin production system using suspension‐cultured tobacco BY‐2 cells

Imamura

Isozumi

Higashimura

et al. 2018

Plant Biotechnology Journal

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Summary Betalains are plant pigments primarily produced by plants of the order Caryophyllales. Because betalain possesses anti‐inflammatory and anticancer activities, it may be useful as a pharmaceutical agent and dietary supplement. Recent studies have identified the genes involved in the betalain biosynthesis of betanin. Amaranthin and celosianin II are abundant in the quinoa ( Chenopodium quinoa Willd.) hypocotyl, and amaranthin comprises glucuronic acid bound to betanin; therefore, this suggests the existence of a glucuronyltransferase involved in the synthesis of amaranthin in the quinoa hypocotyl. To identify the gene involved in amaranthin biosynthesis, we performed a BLAST analysis and phylogenetic tree analysis based on sequences homologous to flavonoid glycosyltransferase, followed by expression analysis on the quinoa hypocotyl to obtain three candidate proteins. Production of amaranthin in a transient Nicotiana benthamiana expression system was evaluated for these candidates and one was identified as having the ability to produce amaranthin. The gene encoding this protein was quinoa amaranthin synthetase 1 ( CqAmaSy1 ). We also created a transgenic tobacco bright yellow‐2 ( BY ‐2) cell line wherein four betalain biosynthesis genes were introduced to facilitate amaranthin production. This transgenic cell line produced 13.67 ± 4.13 μ m (mean ± SEM ) amaranthin and 26.60 ± 1.53 μ m betanin, whereas the production of isoamaranthin and isobetanin could not be detected. Tests confirmed the ability of amaranthin and betanin to slightly suppress cancer cell viability. Furthermore, amaranthin was shown to significantly inhibit HIV ‐1 protease activity, whereas betanin did not.

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“…Commonly used natural food pigments include anthocyanins, carotenoids, betalains, and chlorophylls, among others. In addition to their food application, the consumption of these natural‐colored compounds has been associated with a reduction of noncommunicable diseases such as cancer, diabetes, and obesity (Li and others ; Cooperstone and Schwartz ; Rodriguez and others ). This effect implies a value‐added concept for natural pigments utilization.…”

Section: Introductionmentioning

confidence: 99%

Natural Pigments: Stabilization Methods of Anthocyanins for Food Applications

Cortez

Luna‐Vital

Margulis

et al. 2016

Comp Rev Food Sci Food Safe

409

214

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The production of natural food pigments continues to grow worldwide. The global market is expected to grow at a compound annual growth rate of 6.22%, by revenue, over the period 2015 to 2019. Pigments such as anthocyanins, carotenoids, betalains, and chlorophylls have been used to color foods. However, there are challenges related to color losses during food processing, storage, and commercialization due to a low stability of natural pigments compared to synthetic colorants. This review summarizes the most recent studies and patents aimed at enhancing anthocyanin stability in food systems. The stabilizing methods include additions of copigment compounds, such as polymers, phenolic compounds, and metals. In addition, the exclusion of O 2 during processing and storage, hard-panned candy coating methods for blue, green, and brown colors, and various encapsulation techniques were considered. Combining strategies and evaluating new materials capable of stabilizing anthocyanins will enhance their potential for use as value-added natural food pigments.

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Health‐promoting bioactivities of betalains from red dragon fruit (Hylocereus polyrhizus (Weber) Britton and Rose) peels as affected by carbohydrate encapsulation

Abstract: The study showed that the antioxidant, anti-inflammatory, antiangiogenic and GST-inducing activities of betalains from red dragon fruit peels were enhanced through carbohydrate encapsulation. © 2016 Society of Chemical Industry.

Cited by 59 publications

References 50 publications

Opuntia ficus‐indica (L.) Mill. fruit as source of betalains with antioxidant, cytoprotective, and anti‐angiogenic properties

Opuntia ficus‐indica (L.) Mill. fruit as source of betalains with antioxidant, cytoprotective, and anti‐angiogenic properties

Isolation of amaranthin synthetase from Chenopodium quinoa and construction of an amaranthin production system using suspension‐cultured tobacco BY‐2 cells

Natural Pigments: Stabilization Methods of Anthocyanins for Food Applications

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