Bee venom anti-idiotypic antibody is associated with protection in beekeepers and bee sting-sensitive patients receiving immunotherapy against allergic reactions

The natural history of Apis‐specific IgG and IgG4 in beekeepers

“…Furthermore there might be other poorly understood factors involved, such as anti-idiotypic antibodies [19,20]. In our study most subjects who reported important reactions to stings at some point, also reported less intense reactions to subsequent stings.…”

Wasp venom immunotherapy changes IgG antibody specificity

“…This distinction appears antigen speciflc since wasp allergic and VIT sera prevent similarly the binding of mite allergic pooled IgG to Der p I, exactly as control sera do. Autologous anti-idiotypic antibodies usually restored in the serum of patients allergic to hymenoptera venom by VIT [25,26] could have interfered in the competitive inhibition experiments. However, this possibility was virtually excluded.…”

The production of monovalent and anti-idiotype antivenom against Mesobuthus eupeus (Scorpionida: Buthidae) venom in rabbits

“…Protective roles of anti-Idiotype against bee sting-allergic reactions were proved (Khan et al, 1991). Anti-idiotypic antibodies could play a role in the regulation of IgE synthesis to protect beekeepers against systemic reactions occurring during active immunotherapy (Boutin et al, 1994).…”