Bedside Immune Monitoring: An Automated Immunoassay Platform for Quantification of Blood Biomarkers in Patient Serum within 20 Minutes

Zirath, Helene; Schnetz, G.; Glatz, Andreas; Spittler, Andreas; Redl, Heinz; Peham, Johannes R.

doi:10.1021/acs.analchem.6b03624

Cited by 18 publications

(19 citation statements)

References 27 publications

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“…The IMMULITE® system offers sensitive biomarker quantification, including an inflammation panel. The IMMULITE® 1,000 system is a small benchtop immunoanalyzer that is easy to use with a low cost of operation (Zirath et al, 2017 ). Chaemsaithong et al ( 2015 ) compared the concentrations of IL-6 and IP-10 in amniotic fluid determined by standard enzyme-linked immunosorbent assay (ELISA) and a lateral flow-based immunoassay and reported that the results of the POC test strongly correlated with concentrations as determined by ELISA.…”

Section: Alternative Approaches As Potential Diagnostic Avenues For Tmentioning

confidence: 99%

Bacterial Vaginosis: Current Diagnostic Avenues and Future Opportunities

Redelinghuys

Geldenhuys

Jung

et al. 2020

Front. Cell. Infect. Microbiol.

112

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A healthy female genital tract harbors a microbiome dominated by lactic acid and hydrogen peroxide producing bacteria, which provide protection against infections by maintaining a low pH. Changes in the bacterial compositions of the vaginal microbiome can lead to bacterial vaginosis (BV), which is often associated with vaginal inflammation. Bacterial vaginosis increases the risk of acquiring sexually transmitted infections (STIs) like human immunodeficiency virus (HIV) and affects women's reproductive health negatively. In pregnant women, BV can lead to chorioamnionitis and adverse pregnancy outcomes, including preterm premature rupture of the membranes and preterm birth. In order to manage BV effectively, good diagnostic procedures are required. Traditionally clinical and microscopic methods have been used to diagnose BV; however, these methods require skilled staff and time and suffer from reduced sensitivity and specificity. New diagnostics, including highly sensitive and specific point-of-care (POC) tests, treatment modalities and vaccines can be developed based on the identification of biomarkers from the growing pool of vaginal microbiome and vaginal metabolome data. In this review the current and future diagnostic avenues will be discussed.

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Section: Alternative Approaches As Potential Diagnostic Avenues For Tmentioning

confidence: 99%

Bacterial Vaginosis: Current Diagnostic Avenues and Future Opportunities

Redelinghuys

Geldenhuys

Jung

et al. 2020

Front. Cell. Infect. Microbiol.

112

View full text Add to dashboard Cite

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“…Cooperation with automated machines is another research hotpot in POC fields. [67,68] A portable and automated Figure 7. The manipulation of liquids in microdevices.…”

Section: Manipulation Of Liquid Reagentsmentioning

confidence: 99%

Advances in Reagents Storage and Release in Self‐Contained Point‐of‐Care Devices

Deng

Jiang

2019

Adv Materials Technologies

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Microfluidics has emerged as a useful material for point‐of‐care testing. However, conventional microfluidic devices rely on multiple steps to complete the detection process, which may not be acceptable for untrained users. The emerging “self‐contained” point‐of‐care devices, with all necessary reagents prestored in, address this limitation. This paper summarizes the recent advances of self‐contained point‐of‐care devices, with emphasis on the approaches for reagents integration and manipulation. Due to the intrinsic similarity and relevance of these approaches in pharmaceutical applications, several examples about drug delivery in vivo are presented. Different approaches are compared and future trends for the development of self‐contained point‐of‐care devices are outlined.

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“…Phospholipases A2 (PLA2) and sPLA2-IB 46,47 Lateral flow assay 46,47 Optical detection 46,47 Serum interleukin-8 (IL-8) 48 Microfluidic chip with magnetic beads Chemiluminescent assay Serum Typtophan 49 Aptamer-based Electrochemical biosensor Serum, saliva and urine Anticoagulants, unfractionated herapin and low molecular weight herapin 50…”

Section: Serummentioning

confidence: 99%