Beau's Lines and Multiple Periungueal Pyogenic Granulomas After Long Stay in an Intensive Care Unit

Guhl, Guillermo; Torrelo, Antonio; Hernández, Ángela; Zambrano, Antonio

doi:10.1111/j.1525-1470.2008.00657.x

Cited by 19 publications

(4 citation statements)

References 4 publications

(4 reference statements)

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“…The authors suspected drugs and minor traumas as underlying cause. 6 An adult patient developed multiple perinugual PG on the feet after 5-fluorouracil treatment of rectal cancer, another during reverse transcriptase inhibitor therapy for human immunodeficiency virus infection (Table 1). 7,8 In the present case long-standing immunosuppression with impairment of peringugual and subungual skin integrity and minor traumas might be responsible for the development of multiple PG on fingers and toes.…”

Section: Figurementioning

confidence: 99%

Multiple eruptive periungual pyogenic granulomas during anti-CD20 monoclonal antibody therapy for rheumatoid arthritis

Wollina

2010

J Dermatol Case Rep

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Background: New targeted therapies have been developed for inflammatory and neoplastic diseases.Main observation: We report on a 73-year-old woman who developed multiple eruptive periungual and subungual pyogenic granulomas. Because of severe rheumatoid arthritis the patient was treated with monoclonal anti-CD20 antibodies. Eruptive granuloma pyogenicum developed after the second antibody application and remained more than 8 weeks after targeted therapy was over. New lesions, however, did not appear.Conclusion: Eruptive granuloma pyogenicum of the nail apparatus is a possible new rare adverse effect of targeted therapies. To the best of our knowledge this is the first case in association with anti-CD20 antibody treatment.

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Section: Figurementioning

confidence: 99%

Multiple eruptive periungual pyogenic granulomas during anti-CD20 monoclonal antibody therapy for rheumatoid arthritis

Wollina

2010

J Dermatol Case Rep

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“…The literature also contains further reports of appearance of periungual PGs after peripheral nerve injury. A 9‐year‐old boy developed PGs in the proximal nail folds of three fingers 2 months after several episodes of oxygen desaturation 45 . The development of periungual PGs has also been reported after Guillain–Barré syndrome 46 and in patients with hemiplegia 47 …”

Section: Discussionmentioning

confidence: 92%

Periungual and subungual pyogenic granuloma

Piraccini

Bellavista

Misciali

et al. 2010

British Journal of Dermatology

115

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“…3 Furthermore, underlying skin diseases (eczema, psoriasis, pemphigus vulgaris), hormonal changes (pregnancy, estroprogestinic pill) and peripheral nerve injury might trigger PG development 3,13,14 ; PG can also present after plaster cast immobilization even without neurological abnormalities, 15 reflex sympathetic dystrophy, 16 Guillan Barré syndrome or immobilization in intensive care unit. 17 Although rarely, polydactylous PG can manifest in the setting of concomitant systemic conditions such as sarcoidosis, Langerhans cell histiocytosis or spondylarthritis. 2,3,12,18 Most commonly, polydactylous PG is secondary to the exposition to drugs (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Belimumab-induced periungual pyogenic granulomas: A case report

Chighizola,

Suardi,

Marino

et al. 2024

Lupus

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Pyogenic granuloma (PG) is a benign vascular neoformation, presenting as a painful red nodule on the skin, mucosa or nail apparatus. It is usually related to local complications such as bleedings and superinfections. The etiology of PG remains still unclear, and several triggers can lead to its formation. In case of multiple lesions, systemic conditions and drugs remain the main causes. Antineoplastic treatments, retinoids, antiretrovirals, hormones and anticonvulsants are frequently implicated in PG formation. In literature, PG has been rarely described in the course of biological treatment due to rheumatological disease. The present case report describes the development of polydactolous PGs in a 21-year-old woman with juvenile systemic lupus erythematosus (jSLE) during treatment with belimumab, a monoclonal antibody directed against BlyS. The clinical presentation, in particular the timing and the multiplicity of the lesions, and the improvement after belimumab discontinuation allowed us to consider PG as drug-induced. This case highlights the importance of considering PG as a potential complication of rheumatologic treatments.

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Beau's Lines and Multiple Periungueal Pyogenic Granulomas After Long Stay in an Intensive Care Unit

Abstract: A child developed multiple Beau's lines and periungueal pyogenic granulomas after admission to the intensive care unit. Immobilization, hypoxia, and drugs might have acted as potential causative factors.

Cited by 19 publications

References 4 publications

Multiple eruptive periungual pyogenic granulomas during anti-CD20 monoclonal antibody therapy for rheumatoid arthritis

Multiple eruptive periungual pyogenic granulomas during anti-CD20 monoclonal antibody therapy for rheumatoid arthritis

Periungual and subungual pyogenic granuloma

Belimumab-induced periungual pyogenic granulomas: A case report

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