Bearing arms against osteoarthritis and sarcopenia: when cartilage and skeletal muscle find common interest in talking together

Ceuninck, Frédéric De; Fradin, Armel; Pastoureau, Philippe

doi:10.1016/j.drudis.2013.08.004

Cited by 47 publications

(43 citation statements)

References 70 publications

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“…One explanation for this association is the endocrine effect of fatty tissue compared to muscle mass in sarcopenic obesity, which affects knee OA 5e9 . The other effect of sarcopenic obesity is that the mechanical effect of soft tissue around the knee to control loading is decreased 15 . We showed that obesity with a low percentage of muscle mass in both lower extremities, like sarcopenic obesity, had a greater association with knee OA than did obesity with a normal percentage of muscle mass in both lower extremities, which was similar to nonsarcopenic obesity.…”

Section: Discussionmentioning

confidence: 99%

“…Sarcopenia has been defined as a loss of muscle and consequently of muscle function associated with the physiologic aging process, disuse after limb surgery, endocrine disease such as diabetes mellitus (DM), and unbalanced nutrient intake 11e14 . Sarcopenia may be an important risk factor for OA because it could contribute mechanically to the pathogenesis of knee OA 15,16 . Inflammatory cytokines in OA patients increase protein catabolism and induce the depletion of muscle mass and sarcopenia 17 , and the disuse of a painful joint due to OA reduces muscle tone and muscle mass 15,18 .…”

Section: Introductionmentioning

confidence: 99%

“…Sarcopenia may be an important risk factor for OA because it could contribute mechanically to the pathogenesis of knee OA 15,16 . Inflammatory cytokines in OA patients increase protein catabolism and induce the depletion of muscle mass and sarcopenia 17 , and the disuse of a painful joint due to OA reduces muscle tone and muscle mass 15,18 . In particular, lower extremity lean body mass (LBM) appears to contribute to the development of OA, particularly knee OA 16,19 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Body composition is more closely related to the development of knee osteoarthritis in women than men: a cross-sectional study using the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-1, 2)

Han

Hong

Park

et al. 2016

Osteoarthritis and Cartilage

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Body composition is more closely related to the development of knee osteoarthritis in women than men: a cross-sectional study using the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-1, 2)

Han

Hong

Park

et al. 2016

Osteoarthritis and Cartilage

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“…Muscle-derived stem cells (MDSCs) and satellite cells are thought to contribute to repair of skeletal muscle and bone [18–20]. Although the exact mechanisms remain to be elucidated, cartilage and muscle health has been provocatively linked with changes in or lack of multipotent cell activity, including diseases such as osteoarthritis (OA, cartilage), sarcopenia (muscle), and related muscle and motor neuron diseases [21]. …”

Section: Sourcingmentioning

confidence: 99%

Secreted trophic factors of mesenchymal stem cells support neurovascular and musculoskeletal therapies

2016

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Adult mesenchymal stem cells (MSCs) represent a subject of intense experimental and biomedical interest. Recently, trophic activities of MSCs have become the topic of a number of revealing studies that span both basic and clinical fields. In this review, we focus on recent investigations that have elucidated trophic mechanisms and shed light on MSC clinical efficacy relevant to musculoskeletal applications. Innate differences due to MSC sourcing may play a role in the clinical utility of isolated MSCs. Pain management, osteochondral, nerve, or blood vessel support by MSCs derived from both autologous and allogeneic sources have been examined. Recent mechanistic insights into the trophic activities of these cells point to ultimate regulation by nitric oxide, nuclear factor-kB, and indoleamine, among other signaling pathways. Classic growth factors and cytokines—such as VEGF, CNTF, GDNF, TGF-β, interleukins (IL-1β, IL-6, and IL-8), and C-C ligands (CCL-2, CCL-5, and CCL-23)—serve as paracrine control molecules secreted or packaged into extracellular vesicles, or exosomes, by MSCs. Recent studies have also implicated signaling by microRNAs contained in MSC-derived exosomes. The response of target cells is further regulated by their microenvironment, involving the extracellular matrix, which may be modified by MSC-produced matrix metalloproteinases (MMPs) and tissue inhibitor of MMPs. Trophic activities of MSCs, either resident or introduced exogenously, are thus intricately controlled, and may be further fine-tuned via implant material modifications. MSCs are actively being investigated for the repair and regeneration of both osteochondral and other musculoskeletal tissues, such as tendon/ligament and meniscus. Future rational and effective MSC-based musculoskeletal therapies will benefit from better mechanistic understanding of MSC trophic activities, for example using analytical “-omics” profiling approaches.

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“…Последние годы хроническая скелетно-мышечная боль (боль в спине вследствие дегенеративных изменений позвоночника, боли в суставах вследствие остеоартрита) в пожилой популяции рассматривается во взаимосвязи с развитием и прогрессированием саркопении [21,22].…”

Section: взаимосвязь саркопении и хронической болиunclassified

Chronic pain in older people: focus on sarcopenia

Наумов¹,

Мороз²,

Ховасова³

et al. 2019

Medicinskij sovet

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Наумов Антон Вячеславовичд.м.н., профессор кафедры болезней старения ФДПО Федерального государственного бюджетного образовательного учреждения высшего образования «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова», заведующий лабораторией костно-мышечной системы Обособленного структурного подразделения «Российский геронтологический научно-клинический центр» Федерального государственного бюджетного образовательного учреждения высшего образования «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Министерства здравоохранения Российской Федерации; старший научный сотрудник Федерального центра координации деятельности субъектов Российской Федерации по развитию организации оказания медицинской помощи по профилю «гериатрия»; тел.:

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Bearing arms against osteoarthritis and sarcopenia: when cartilage and skeletal muscle find common interest in talking together

Cited by 47 publications

References 70 publications

Body composition is more closely related to the development of knee osteoarthritis in women than men: a cross-sectional study using the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-1, 2)

Body composition is more closely related to the development of knee osteoarthritis in women than men: a cross-sectional study using the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-1, 2)

Secreted trophic factors of mesenchymal stem cells support neurovascular and musculoskeletal therapies

Chronic pain in older people: focus on sarcopenia

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